Hepatoblastoma with precocious puberty
Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious p...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of Indian Association of Pediatric Surgeons |
| Subjects: | |
| Online Access: | http://www.jiaps.com/article.asp?issn=0971-9261;year=2019;volume=24;issue=1;spage=68;epage=71;aulast=Yhoshu |
| _version_ | 1818303762426494976 |
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| author | Enono Yhoshu Yasir A Lone Jai K Mahajan Umesh Bahadur Singh |
| author_facet | Enono Yhoshu Yasir A Lone Jai K Mahajan Umesh Bahadur Singh |
| author_sort | Enono Yhoshu |
| collection | DOAJ |
| description | Hepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious puberty wherein hormonal assays showed an increase in α-FP, β-hCG, and testosterone levels, and suppression of follicle-stimulating and luteinizing hormone levels. After chemotherapy and surgery, α-FP, β-hCG, and testosterone levels normalized, and the signs of virilization did not progress further. New therapeutic approaches have made a previously reported grim prognosis of virilizing HB, more favorable now. In the assessment of PPP, the possibility of a tumoral source for the hormones should also be considered. |
| first_indexed | 2024-12-13T05:59:57Z |
| format | Article |
| id | doaj.art-6d37850f177b42f1be2ca2ec8411ab1f |
| institution | Directory Open Access Journal |
| issn | 0971-9261 1998-3891 |
| language | English |
| last_indexed | 2024-12-13T05:59:57Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Association of Pediatric Surgeons |
| spelling | doaj.art-6d37850f177b42f1be2ca2ec8411ab1f2022-12-21T23:57:22ZengWolters Kluwer Medknow PublicationsJournal of Indian Association of Pediatric Surgeons0971-92611998-38912019-01-01241687110.4103/jiaps.JIAPS_102_18Hepatoblastoma with precocious pubertyEnono YhoshuYasir A LoneJai K MahajanUmesh Bahadur SinghHepatoblastoma (HB), a primary liver tumor of childhood, is often accompanied by raised levels of alpha-fetoprotein (α-FP). Rarely, the beta-human chorionic gonadotropin (β-hCG) levels may also be elevated, which can cause peripheral precocious puberty (PPP). We report a case of HB with precocious puberty wherein hormonal assays showed an increase in α-FP, β-hCG, and testosterone levels, and suppression of follicle-stimulating and luteinizing hormone levels. After chemotherapy and surgery, α-FP, β-hCG, and testosterone levels normalized, and the signs of virilization did not progress further. New therapeutic approaches have made a previously reported grim prognosis of virilizing HB, more favorable now. In the assessment of PPP, the possibility of a tumoral source for the hormones should also be considered.http://www.jiaps.com/article.asp?issn=0971-9261;year=2019;volume=24;issue=1;spage=68;epage=71;aulast=YhoshuHepatoblastomaprecociouspubertyvirilization |
| spellingShingle | Enono Yhoshu Yasir A Lone Jai K Mahajan Umesh Bahadur Singh Hepatoblastoma with precocious puberty Journal of Indian Association of Pediatric Surgeons Hepatoblastoma precocious puberty virilization |
| title | Hepatoblastoma with precocious puberty |
| title_full | Hepatoblastoma with precocious puberty |
| title_fullStr | Hepatoblastoma with precocious puberty |
| title_full_unstemmed | Hepatoblastoma with precocious puberty |
| title_short | Hepatoblastoma with precocious puberty |
| title_sort | hepatoblastoma with precocious puberty |
| topic | Hepatoblastoma precocious puberty virilization |
| url | http://www.jiaps.com/article.asp?issn=0971-9261;year=2019;volume=24;issue=1;spage=68;epage=71;aulast=Yhoshu |
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