SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates
Abstract The effects of heterogeneous infection, vaccination and boosting histories prior to and during pregnancy have not been extensively studied and are likely important for protection of neonates. We measure levels of spike binding antibodies in 4600 patients and their neonates with different va...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-39989-y |
| _version_ | 1797743990742712320 |
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| author | Elisabeth A. Murphy Camila Guzman-Cardozo Ashley C. Sukhu Debby J. Parks Malavika Prabhu Iman Mohammed Magdalena Jurkiewicz Thomas J. Ketas Sunidhi Singh Marie Canis Eva Bednarski Alexis Hollingsworth Embree M. Thompson Dorothy Eng Paul D. Bieniasz Laura E. Riley Theodora Hatziioannou Yawei J. Yang |
| author_facet | Elisabeth A. Murphy Camila Guzman-Cardozo Ashley C. Sukhu Debby J. Parks Malavika Prabhu Iman Mohammed Magdalena Jurkiewicz Thomas J. Ketas Sunidhi Singh Marie Canis Eva Bednarski Alexis Hollingsworth Embree M. Thompson Dorothy Eng Paul D. Bieniasz Laura E. Riley Theodora Hatziioannou Yawei J. Yang |
| author_sort | Elisabeth A. Murphy |
| collection | DOAJ |
| description | Abstract The effects of heterogeneous infection, vaccination and boosting histories prior to and during pregnancy have not been extensively studied and are likely important for protection of neonates. We measure levels of spike binding antibodies in 4600 patients and their neonates with different vaccination statuses, with and without history of SARS-CoV-2 infection. We investigate neutralizing antibody activity against different SARS-CoV-2 variant pseudotypes in a subset of 259 patients and determined correlation between IgG levels and variant neutralizing activity. We further study the ability of maternal antibody and neutralizing measurements to predict neutralizing antibody activity in the umbilical cord blood of neonates. In this work, we show SARS-CoV-2 vaccination and boosting, especially in the setting of previous infection, leads to significant increases in antibody levels and neutralizing activity even against the recent omicron BA.1 and BA.5 variants in both pregnant patients and their neonates. |
| first_indexed | 2024-03-12T15:03:26Z |
| format | Article |
| id | doaj.art-6d381e7c295f4d94bdcb49c6735ccd37 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-03-12T15:03:26Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6d381e7c295f4d94bdcb49c6735ccd372023-08-13T11:16:31ZengNature PortfolioNature Communications2041-17232023-08-0114111010.1038/s41467-023-39989-ySARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonatesElisabeth A. Murphy0Camila Guzman-Cardozo1Ashley C. Sukhu2Debby J. Parks3Malavika Prabhu4Iman Mohammed5Magdalena Jurkiewicz6Thomas J. Ketas7Sunidhi Singh8Marie Canis9Eva Bednarski10Alexis Hollingsworth11Embree M. Thompson12Dorothy Eng13Paul D. Bieniasz14Laura E. Riley15Theodora Hatziioannou16Yawei J. Yang17Department of Pathology and Laboratory Medicine, Weill Cornell MedicineLaboratory of Retrovirology, The Rockefeller UniversityDepartment of Pathology and Laboratory Medicine, New York Presbyterian/Weill Cornell Medical CenterLaboratory of Retrovirology, The Rockefeller UniversityDepartment of Obstetrics & Gynecology, Weill Cornell MedicineDepartment of Obstetrics & Gynecology, Weill Cornell MedicineDepartment of Pathology and Laboratory Medicine, Weill Cornell MedicineDepartment of Microbiology and Immunology, Weill Cornell MedicineWeill Cornell MedicineLaboratory of Retrovirology, The Rockefeller UniversityLaboratory of Retrovirology, The Rockefeller UniversityWeill Cornell MedicineWeill Cornell MedicineDepartment of Pathology and Laboratory Medicine, New York Presbyterian/Weill Cornell Medical CenterLaboratory of Retrovirology, The Rockefeller UniversityDepartment of Obstetrics & Gynecology, Weill Cornell MedicineLaboratory of Retrovirology, The Rockefeller UniversityDepartment of Pathology and Laboratory Medicine, Weill Cornell MedicineAbstract The effects of heterogeneous infection, vaccination and boosting histories prior to and during pregnancy have not been extensively studied and are likely important for protection of neonates. We measure levels of spike binding antibodies in 4600 patients and their neonates with different vaccination statuses, with and without history of SARS-CoV-2 infection. We investigate neutralizing antibody activity against different SARS-CoV-2 variant pseudotypes in a subset of 259 patients and determined correlation between IgG levels and variant neutralizing activity. We further study the ability of maternal antibody and neutralizing measurements to predict neutralizing antibody activity in the umbilical cord blood of neonates. In this work, we show SARS-CoV-2 vaccination and boosting, especially in the setting of previous infection, leads to significant increases in antibody levels and neutralizing activity even against the recent omicron BA.1 and BA.5 variants in both pregnant patients and their neonates.https://doi.org/10.1038/s41467-023-39989-y |
| spellingShingle | Elisabeth A. Murphy Camila Guzman-Cardozo Ashley C. Sukhu Debby J. Parks Malavika Prabhu Iman Mohammed Magdalena Jurkiewicz Thomas J. Ketas Sunidhi Singh Marie Canis Eva Bednarski Alexis Hollingsworth Embree M. Thompson Dorothy Eng Paul D. Bieniasz Laura E. Riley Theodora Hatziioannou Yawei J. Yang SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates Nature Communications |
| title | SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates |
| title_full | SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates |
| title_fullStr | SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates |
| title_full_unstemmed | SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates |
| title_short | SARS-CoV-2 vaccination, booster, and infection in pregnant population enhances passive immunity in neonates |
| title_sort | sars cov 2 vaccination booster and infection in pregnant population enhances passive immunity in neonates |
| url | https://doi.org/10.1038/s41467-023-39989-y |
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