The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy
Diabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by high blood glucose levels either due to an absolute deficiency of insulin secretion or an ineffective response of cells to insulin, a hormone synthetized by β-cells in the pancreas. Despite the current substantial...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.927324/full |
| _version_ | 1828299874952544256 |
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| author | Xin Wang Xin Wang Mengxi Gao Mengxi Gao Yali Wang Yucheng Zhang |
| author_facet | Xin Wang Xin Wang Mengxi Gao Mengxi Gao Yali Wang Yucheng Zhang |
| author_sort | Xin Wang |
| collection | DOAJ |
| description | Diabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by high blood glucose levels either due to an absolute deficiency of insulin secretion or an ineffective response of cells to insulin, a hormone synthetized by β-cells in the pancreas. Despite the current substantial progress of new drugs and strategies to prevent and treat diabetes, we do not understand precisely the exact cause of the failure and impairment of β-cells. Therefore, there is an urgent need to find new methods to restore β-cells. In recent years, pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) can serve as an ideal alternative source for the pancreatic β-cells. In this review, we systematically summarize the current progress and protocols of generating pancreatic β-cells from human PSCs. Meanwhile, we also discuss some challenges and future perspectives of human PSCs treatments for diabetes. |
| first_indexed | 2024-04-13T13:00:33Z |
| format | Article |
| id | doaj.art-6d3b32858028481d99e44aa8d8175128 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T13:00:33Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-6d3b32858028481d99e44aa8d81751282022-12-22T02:45:56ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-07-011310.3389/fendo.2022.927324927324The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapyXin Wang0Xin Wang1Mengxi Gao2Mengxi Gao3Yali Wang4Yucheng Zhang5China-Japan Union Hospital of Jilin University, Changchun, ChinaThe Third Norman Bethune Clinical College of Jilin University, Changchun, ChinaChina-Japan Union Hospital of Jilin University, Changchun, ChinaThe Third Norman Bethune Clinical College of Jilin University, Changchun, ChinaDepartment of Blood Transfusion, China–Japan Union Hospital of Jilin University, Changchun, ChinaScientific Research Center, China–Japan Union Hospital of Jilin University, Changchun, ChinaDiabetes is a complex metabolic disorder of carbohydrate metabolism, characterized by high blood glucose levels either due to an absolute deficiency of insulin secretion or an ineffective response of cells to insulin, a hormone synthetized by β-cells in the pancreas. Despite the current substantial progress of new drugs and strategies to prevent and treat diabetes, we do not understand precisely the exact cause of the failure and impairment of β-cells. Therefore, there is an urgent need to find new methods to restore β-cells. In recent years, pluripotent stem cells (PSCs) such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) can serve as an ideal alternative source for the pancreatic β-cells. In this review, we systematically summarize the current progress and protocols of generating pancreatic β-cells from human PSCs. Meanwhile, we also discuss some challenges and future perspectives of human PSCs treatments for diabetes.https://www.frontiersin.org/articles/10.3389/fendo.2022.927324/fulldiabetes mellitusstem cellsgenerationhuman pluripotent stem cellsembryonic stem cells |
| spellingShingle | Xin Wang Xin Wang Mengxi Gao Mengxi Gao Yali Wang Yucheng Zhang The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy Frontiers in Endocrinology diabetes mellitus stem cells generation human pluripotent stem cells embryonic stem cells |
| title | The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy |
| title_full | The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy |
| title_fullStr | The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy |
| title_full_unstemmed | The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy |
| title_short | The progress of pluripotent stem cell-derived pancreatic β-cells regeneration for diabetic therapy |
| title_sort | progress of pluripotent stem cell derived pancreatic β cells regeneration for diabetic therapy |
| topic | diabetes mellitus stem cells generation human pluripotent stem cells embryonic stem cells |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.927324/full |
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