Nucleophilic displacement reactions of 5′-derivatised nucleosides in a vibration ball mill

Nucleophilic displacement reactions of 5′-derivatised nucleosides in a vibration ball mill

Vibration ball-milling in a zirconia-lined vessel afforded clean and quantitative nucleophilic displacement reactions between 4-methoxybenzylthiolate salts and nucleoside 5′-halides or 5′-tosylates in five to 60 minutes. Under these conditions, commonly-encountered nucleoside cyclisation byproducts...

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Bibliographic Details
Main Authors: Olga Eguaogie, Patrick F. Conlon, Francesco Ravalico, Jamie S. T. Sweet, Thomas B. Elder, Louis P. Conway, Marc E. Lennon, David R. W. Hodgson, Joseph S. Vyle
Format: Article
Language:English
Published: Beilstein-Institut 2017-01-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
ball mill
chalcogen
mechanochemistry
nucleophilic substitution
nucleoside
Online Access:https://doi.org/10.3762/bjoc.13.11

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