Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia

Insights about the structure of farnesyl diphosphate synthase (FPPS) and the activity of bisphosphonates on the proliferation and ultrastructure of Leishmania and Giardia

Abstract Background The enzyme farnesyl diphosphate synthase (FPPS) is positioned in the intersection of different sterol biosynthesis pathways such as those producing isoprenoids, dolichols and ergosterol. FPPS is ubiquitous in eukaryotes and is inhibited by nitrogen-containing bisphosphonates (N-B...

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Bibliographic Details
Main Authors: Ana Paula R. Gadelha, Claudia Maia Brigagao, Martha Barros da Silva, Aline Beatriz Mello Rodrigues, Ana Carolina Ramos Guimarães, Fernando Paiva, Wanderley de Souza, Cristina Henriques
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Parasites & Vectors
Subjects:
Bisphosphonates
Farnesyl diphosphate synthase
FPPS
Leishmania
Giardia
Protozoan
Online Access:http://link.springer.com/article/10.1186/s13071-020-04019-z

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http://link.springer.com/article/10.1186/s13071-020-04019-z

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