2型糖尿病患者就诊间血压变异性与大血管和微血管并发症的风险:一项中国初级保健队列研究
Abstract Background We evaluated the effects of visit‐to‐visit variability of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on macrovascular and microvascular complications among patients with type 2 diabetes. Methods A total of 11 043 patients with type 2 diabetes from primary he...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-11-01
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| Series: | Journal of Diabetes |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/1753-0407.13331 |
| _version_ | 1797951588369694720 |
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| author | Ying Deng Yin Liu Shengchao Zhang Hanbing Yu Xiaozhou Zeng Rongrong An Zhenyuan Chen Na Sun Xiaoxv Yin Yue Dong |
| author_facet | Ying Deng Yin Liu Shengchao Zhang Hanbing Yu Xiaozhou Zeng Rongrong An Zhenyuan Chen Na Sun Xiaoxv Yin Yue Dong |
| author_sort | Ying Deng |
| collection | DOAJ |
| description | Abstract Background We evaluated the effects of visit‐to‐visit variability of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on macrovascular and microvascular complications among patients with type 2 diabetes. Methods A total of 11 043 patients with type 2 diabetes from primary healthcare institutions between January 2010 and June 2020 were included. The visit‐to‐visit blood pressure variability was calculated using three metrics: SD, coefficient of variation (CV), and average real variability (ARV), obtained over a 12‐month measurement period. The associations of visit‐to‐visit blood pressure variability with macrovascular and microvascular complications were evaluated using multivariate‐adjusted Cox proportional hazards models, and hazard ratio (HR) with 95% confidence interval (CI) were reported. Results There were 330 macrovascular events and 542 microvascular events. Compared to those for participants with the lowest quartile of SD of SBP and DBP, increased risks were observed in patients with the highest quartile of SD of SBP and DBP for macrovascular complications (SD‐SBP: HR = 1.78, 95% CI: 1.24–2.57; SD‐DBP: HR = 2.20, 95% CI: 1.50–3.25) and microvascular complications (SD‐SBP: HR = 1.85, 95% CI: 1.39–2.46; SD‐DBP: HR = 1.82, 95% CI: 1.36–2.44). CV and ARV of SBP and DBP also had statistically significant associations with macrovascular and microvascular complications. The optimal variability of blood pressure target was SD of SBP <6.45 mm Hg and SD of DBP <4.81 mm Hg. Conclusions Visit‐to‐visit blood pressure variability may be a potential predictor for macrovascular and microvascular complications in patients with type 2 diabetes. |
| first_indexed | 2024-04-10T22:32:52Z |
| format | Article |
| id | doaj.art-6d3bc026fc434e0c82fdf8d40fc1e7cd |
| institution | Directory Open Access Journal |
| issn | 1753-0393 1753-0407 |
| language | English |
| last_indexed | 2024-04-10T22:32:52Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes |
| spelling | doaj.art-6d3bc026fc434e0c82fdf8d40fc1e7cd2023-01-17T01:45:41ZengWileyJournal of Diabetes1753-03931753-04072022-11-01141176777910.1111/1753-0407.133312型糖尿病患者就诊间血压变异性与大血管和微血管并发症的风险:一项中国初级保健队列研究Ying Deng0Yin Liu1Shengchao Zhang2Hanbing Yu3Xiaozhou Zeng4Rongrong An5Zhenyuan Chen6Na Sun7Xiaoxv Yin8Yue Dong9Department of Community Health Management Baoan Central Hospital of Shenzhen People's Republic of ChinaDepartment of Community Health Management Baoan Central Hospital of Shenzhen People's Republic of ChinaDepartment of Community Health Management Baoan Central Hospital of Shenzhen People's Republic of ChinaDepartment of Community Health Management Baoan Central Hospital of Shenzhen People's Republic of ChinaDepartment of Community Health Management Baoan Central Hospital of Shenzhen People's Republic of ChinaDepartment of Social Medicine and Health Management, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of ChinaDepartment of Social Medicine and Health Management, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of ChinaDepartment of Social Medicine and Health Management, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of ChinaDepartment of Social Medicine and Health Management, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of ChinaDepartment of Social Medicine and Health Management, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan People's Republic of ChinaAbstract Background We evaluated the effects of visit‐to‐visit variability of systolic blood pressure (SBP) and diastolic blood pressure (DBP) on macrovascular and microvascular complications among patients with type 2 diabetes. Methods A total of 11 043 patients with type 2 diabetes from primary healthcare institutions between January 2010 and June 2020 were included. The visit‐to‐visit blood pressure variability was calculated using three metrics: SD, coefficient of variation (CV), and average real variability (ARV), obtained over a 12‐month measurement period. The associations of visit‐to‐visit blood pressure variability with macrovascular and microvascular complications were evaluated using multivariate‐adjusted Cox proportional hazards models, and hazard ratio (HR) with 95% confidence interval (CI) were reported. Results There were 330 macrovascular events and 542 microvascular events. Compared to those for participants with the lowest quartile of SD of SBP and DBP, increased risks were observed in patients with the highest quartile of SD of SBP and DBP for macrovascular complications (SD‐SBP: HR = 1.78, 95% CI: 1.24–2.57; SD‐DBP: HR = 2.20, 95% CI: 1.50–3.25) and microvascular complications (SD‐SBP: HR = 1.85, 95% CI: 1.39–2.46; SD‐DBP: HR = 1.82, 95% CI: 1.36–2.44). CV and ARV of SBP and DBP also had statistically significant associations with macrovascular and microvascular complications. The optimal variability of blood pressure target was SD of SBP <6.45 mm Hg and SD of DBP <4.81 mm Hg. Conclusions Visit‐to‐visit blood pressure variability may be a potential predictor for macrovascular and microvascular complications in patients with type 2 diabetes.https://doi.org/10.1111/1753-0407.13331血压大血管并发症微血管并发症2型糖尿病 |
| spellingShingle | Ying Deng Yin Liu Shengchao Zhang Hanbing Yu Xiaozhou Zeng Rongrong An Zhenyuan Chen Na Sun Xiaoxv Yin Yue Dong 2型糖尿病患者就诊间血压变异性与大血管和微血管并发症的风险:一项中国初级保健队列研究 Journal of Diabetes 血压 大血管并发症 微血管并发症 2型糖尿病 |
| title | 2型糖尿病患者就诊间血压变异性与大血管和微血管并发症的风险:一项中国初级保健队列研究 |
| title_full | 2型糖尿病患者就诊间血压变异性与大血管和微血管并发症的风险:一项中国初级保健队列研究 |
| title_fullStr | 2型糖尿病患者就诊间血压变异性与大血管和微血管并发症的风险:一项中国初级保健队列研究 |
| title_full_unstemmed | 2型糖尿病患者就诊间血压变异性与大血管和微血管并发症的风险:一项中国初级保健队列研究 |
| title_short | 2型糖尿病患者就诊间血压变异性与大血管和微血管并发症的风险:一项中国初级保健队列研究 |
| title_sort | 2型糖尿病患者就诊间血压变异性与大血管和微血管并发症的风险 一项中国初级保健队列研究 |
| topic | 血压 大血管并发症 微血管并发症 2型糖尿病 |
| url | https://doi.org/10.1111/1753-0407.13331 |
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