The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone
Napabucasin (also known as BBI608) is a natural naphthoquinone originally identified as a cancer cell stemness inhibitor. Accumulated in vitro and in vivo evidence demonstrated that napabucasin showed significant anticancer effects in various types of cancers. Napabucasin inhibits cancer cell prolif...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/15/5678 |
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| author | Zeyang Shao Heng Wang Haiyan Ren Yinxiang Sun Xiuping Chen |
| author_facet | Zeyang Shao Heng Wang Haiyan Ren Yinxiang Sun Xiuping Chen |
| author_sort | Zeyang Shao |
| collection | DOAJ |
| description | Napabucasin (also known as BBI608) is a natural naphthoquinone originally identified as a cancer cell stemness inhibitor. Accumulated in vitro and in vivo evidence demonstrated that napabucasin showed significant anticancer effects in various types of cancers. Napabucasin inhibits cancer cell proliferation, induces apoptosis and cell cycle arrest, and suppresses metastasis and relapse. Such anticancer activities of napabucasin mainly rely on the inhibition of cancer stemness by targeting signal transducer and activator of transcription 3 (STAT3) and its related gene inhibition. However, several novel molecular targets for napabucasin, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and thioredoxin reductase 1 (TrxR1), have been reported. Napabucasin represents a promising anticancer lead for multiple cancers. In this mini review, the anticancer potential and the molecular mechanism of napabucasin will be briefly highlighted. |
| first_indexed | 2024-03-11T00:21:35Z |
| format | Article |
| id | doaj.art-6d3bfcb9fbbe4947a8de0f244659c281 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:21:35Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-6d3bfcb9fbbe4947a8de0f244659c2812023-11-18T23:17:25ZengMDPI AGMolecules1420-30492023-07-012815567810.3390/molecules28155678The Anticancer Effect of Napabucasin (BBI608), a Natural NaphthoquinoneZeyang Shao0Heng Wang1Haiyan Ren2Yinxiang Sun3Xiuping Chen4State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical, University of Macau, Macao, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical, University of Macau, Macao, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical, University of Macau, Macao, ChinaZhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai 519000, ChinaState Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical, University of Macau, Macao, ChinaNapabucasin (also known as BBI608) is a natural naphthoquinone originally identified as a cancer cell stemness inhibitor. Accumulated in vitro and in vivo evidence demonstrated that napabucasin showed significant anticancer effects in various types of cancers. Napabucasin inhibits cancer cell proliferation, induces apoptosis and cell cycle arrest, and suppresses metastasis and relapse. Such anticancer activities of napabucasin mainly rely on the inhibition of cancer stemness by targeting signal transducer and activator of transcription 3 (STAT3) and its related gene inhibition. However, several novel molecular targets for napabucasin, such as NAD(P)H:quinone oxidoreductase 1 (NQO1) and thioredoxin reductase 1 (TrxR1), have been reported. Napabucasin represents a promising anticancer lead for multiple cancers. In this mini review, the anticancer potential and the molecular mechanism of napabucasin will be briefly highlighted.https://www.mdpi.com/1420-3049/28/15/5678napabucasincancerSTAT3NQO1 |
| spellingShingle | Zeyang Shao Heng Wang Haiyan Ren Yinxiang Sun Xiuping Chen The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone Molecules napabucasin cancer STAT3 NQO1 |
| title | The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone |
| title_full | The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone |
| title_fullStr | The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone |
| title_full_unstemmed | The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone |
| title_short | The Anticancer Effect of Napabucasin (BBI608), a Natural Naphthoquinone |
| title_sort | anticancer effect of napabucasin bbi608 a natural naphthoquinone |
| topic | napabucasin cancer STAT3 NQO1 |
| url | https://www.mdpi.com/1420-3049/28/15/5678 |
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