High-risk HPV infection after five years in a population-based cohort of Chilean women
<p>Abstract</p> <p>Background</p> <p>The need to review cervical cancer prevention strategies has been triggered by the availability of new prevention tools linked to human papillomavirus (HPV): vaccines and screening tests. To consider these innovations, information on...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2011-11-01
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| Series: | Infectious Agents and Cancer |
| Online Access: | http://www.infectagentscancer.com/content/6/1/21 |
| _version_ | 1818789133296861184 |
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| author | Ferreccio Catterina Van De Wyngard Vanessa Olcay Fabiola Domínguez M Angélica Puschel Klaus Corvalán Alejandro H Franceschi Silvia Snijders Peter JF |
| author_facet | Ferreccio Catterina Van De Wyngard Vanessa Olcay Fabiola Domínguez M Angélica Puschel Klaus Corvalán Alejandro H Franceschi Silvia Snijders Peter JF |
| author_sort | Ferreccio Catterina |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The need to review cervical cancer prevention strategies has been triggered by the availability of new prevention tools linked to human papillomavirus (HPV): vaccines and screening tests. To consider these innovations, information on HPV type distribution and natural history is necessary. This is a five-year follow-up study of gynecological high-risk (HR) HPV infection among a Chilean population-based cohort of women.</p> <p>Findings</p> <p>A population-based random sample of 969 women from Santiago, Chile aged 17 years or older was enrolled in 2001 and revisited in 2006. At both visits they answered a survey on demographics and sexual history and provided a cervical sample for HPV DNA detection (GP5+/6+ primer-mediated PCR and Reverse line blot genotyping). Follow-up was completed by 576 (59.4%) women; 45 (4.6%) refused participation; most losses to follow-up were women who were unreachable, no longer eligible or had missing samples. HR-HPV prevalence increased by 43%. Incidence was highest in women < 20 years of age (19.4%) and lowest in women > 70 (0%); it was three times higher among women HR-HPV positive versus HPV negative at baseline (25.5% and 8.3%; OR 3.8, 95% CI 1.8-8.0). Type-specific persistence was 35.3%; it increased with age, from 0% in women < 30 years of age to 100% in women > 70. An enrollment Pap result ASCUS or worse was the only risk factor for being HR-HPV positive at both visits.</p> <p>Conclusions</p> <p>HR-HPV prevalence increased in the study population. All HR-HPV infections in women < 30 years old cleared, supporting the current recommendation of HR-HPV screening for women > 30 years.</p> |
| first_indexed | 2024-12-18T14:34:43Z |
| format | Article |
| id | doaj.art-6d3c188b838946e686e433211c80b2ec |
| institution | Directory Open Access Journal |
| issn | 1750-9378 |
| language | English |
| last_indexed | 2024-12-18T14:34:43Z |
| publishDate | 2011-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Infectious Agents and Cancer |
| spelling | doaj.art-6d3c188b838946e686e433211c80b2ec2022-12-21T21:04:31ZengBMCInfectious Agents and Cancer1750-93782011-11-01612110.1186/1750-9378-6-21High-risk HPV infection after five years in a population-based cohort of Chilean womenFerreccio CatterinaVan De Wyngard VanessaOlcay FabiolaDomínguez M AngélicaPuschel KlausCorvalán Alejandro HFranceschi SilviaSnijders Peter JF<p>Abstract</p> <p>Background</p> <p>The need to review cervical cancer prevention strategies has been triggered by the availability of new prevention tools linked to human papillomavirus (HPV): vaccines and screening tests. To consider these innovations, information on HPV type distribution and natural history is necessary. This is a five-year follow-up study of gynecological high-risk (HR) HPV infection among a Chilean population-based cohort of women.</p> <p>Findings</p> <p>A population-based random sample of 969 women from Santiago, Chile aged 17 years or older was enrolled in 2001 and revisited in 2006. At both visits they answered a survey on demographics and sexual history and provided a cervical sample for HPV DNA detection (GP5+/6+ primer-mediated PCR and Reverse line blot genotyping). Follow-up was completed by 576 (59.4%) women; 45 (4.6%) refused participation; most losses to follow-up were women who were unreachable, no longer eligible or had missing samples. HR-HPV prevalence increased by 43%. Incidence was highest in women < 20 years of age (19.4%) and lowest in women > 70 (0%); it was three times higher among women HR-HPV positive versus HPV negative at baseline (25.5% and 8.3%; OR 3.8, 95% CI 1.8-8.0). Type-specific persistence was 35.3%; it increased with age, from 0% in women < 30 years of age to 100% in women > 70. An enrollment Pap result ASCUS or worse was the only risk factor for being HR-HPV positive at both visits.</p> <p>Conclusions</p> <p>HR-HPV prevalence increased in the study population. All HR-HPV infections in women < 30 years old cleared, supporting the current recommendation of HR-HPV screening for women > 30 years.</p>http://www.infectagentscancer.com/content/6/1/21 |
| spellingShingle | Ferreccio Catterina Van De Wyngard Vanessa Olcay Fabiola Domínguez M Angélica Puschel Klaus Corvalán Alejandro H Franceschi Silvia Snijders Peter JF High-risk HPV infection after five years in a population-based cohort of Chilean women Infectious Agents and Cancer |
| title | High-risk HPV infection after five years in a population-based cohort of Chilean women |
| title_full | High-risk HPV infection after five years in a population-based cohort of Chilean women |
| title_fullStr | High-risk HPV infection after five years in a population-based cohort of Chilean women |
| title_full_unstemmed | High-risk HPV infection after five years in a population-based cohort of Chilean women |
| title_short | High-risk HPV infection after five years in a population-based cohort of Chilean women |
| title_sort | high risk hpv infection after five years in a population based cohort of chilean women |
| url | http://www.infectagentscancer.com/content/6/1/21 |
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