Intestinal Microecology of Mice Exposed to TiO<sub>2</sub> Nanoparticles and Bisphenol A
Exposure to titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) and bisphenol A (BPA) is ubiquitous, especially through dietary and other environmental pathways. In the present study, adult C57BL/6J mice were exposed to TiO<sub>2</sub> NPs (100 mg/kg), BPA (0, 5, and 50 mg/k...
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| Format: | Article |
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MDPI AG
2022-06-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/12/1696 |
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| author | Chen Yang Youlan Tan Fengzhu Li Hongbin Wang Ying Lin Fuping Lu Huabing Zhao |
| author_facet | Chen Yang Youlan Tan Fengzhu Li Hongbin Wang Ying Lin Fuping Lu Huabing Zhao |
| author_sort | Chen Yang |
| collection | DOAJ |
| description | Exposure to titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) and bisphenol A (BPA) is ubiquitous, especially through dietary and other environmental pathways. In the present study, adult C57BL/6J mice were exposed to TiO<sub>2</sub> NPs (100 mg/kg), BPA (0, 5, and 50 mg/kg), or their binary mixtures for 13 weeks. The 16S rDNA amplification sequence analysis revealed that co-exposure to TiO<sub>2</sub> NPs and BPA altered the intestinal microbiota; however, this alteration was mainly caused by TiO<sub>2</sub> NPs. Faecal metabolomics analysis revealed that 28 metabolites and 3 metabolic pathways were altered in the co-exposed group. This study is the first to reveal the combined effects of TiO<sub>2</sub> NPs and BPA on the mammalian gut microbial community and metabolism dynamics, which is of great value to human health. The coexistence of TiO<sub>2</sub> NPs and BPA in the gut poses a potential health risk due to their interaction with the gut microbiota. |
| first_indexed | 2024-03-09T23:49:43Z |
| format | Article |
| id | doaj.art-6d3e78d6c7354cd9bca3e67de74934f2 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T23:49:43Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-6d3e78d6c7354cd9bca3e67de74934f22023-11-23T16:37:37ZengMDPI AGFoods2304-81582022-06-011112169610.3390/foods11121696Intestinal Microecology of Mice Exposed to TiO<sub>2</sub> Nanoparticles and Bisphenol AChen Yang0Youlan Tan1Fengzhu Li2Hongbin Wang3Ying Lin4Fuping Lu5Huabing Zhao6College of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaSchool of Biological Science and Engineering, South China University of Technology, Guangzhou 510006, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaCollege of Biotechnology, Tianjin University of Science and Technology, 9 TEDA 13th Street, Tianjin 300457, ChinaExposure to titanium dioxide nanoparticles (TiO<sub>2</sub> NPs) and bisphenol A (BPA) is ubiquitous, especially through dietary and other environmental pathways. In the present study, adult C57BL/6J mice were exposed to TiO<sub>2</sub> NPs (100 mg/kg), BPA (0, 5, and 50 mg/kg), or their binary mixtures for 13 weeks. The 16S rDNA amplification sequence analysis revealed that co-exposure to TiO<sub>2</sub> NPs and BPA altered the intestinal microbiota; however, this alteration was mainly caused by TiO<sub>2</sub> NPs. Faecal metabolomics analysis revealed that 28 metabolites and 3 metabolic pathways were altered in the co-exposed group. This study is the first to reveal the combined effects of TiO<sub>2</sub> NPs and BPA on the mammalian gut microbial community and metabolism dynamics, which is of great value to human health. The coexistence of TiO<sub>2</sub> NPs and BPA in the gut poses a potential health risk due to their interaction with the gut microbiota.https://www.mdpi.com/2304-8158/11/12/1696TiO<sub>2</sub> NPsBPA16S rDNAfaecal metabolomic |
| spellingShingle | Chen Yang Youlan Tan Fengzhu Li Hongbin Wang Ying Lin Fuping Lu Huabing Zhao Intestinal Microecology of Mice Exposed to TiO<sub>2</sub> Nanoparticles and Bisphenol A Foods TiO<sub>2</sub> NPs BPA 16S rDNA faecal metabolomic |
| title | Intestinal Microecology of Mice Exposed to TiO<sub>2</sub> Nanoparticles and Bisphenol A |
| title_full | Intestinal Microecology of Mice Exposed to TiO<sub>2</sub> Nanoparticles and Bisphenol A |
| title_fullStr | Intestinal Microecology of Mice Exposed to TiO<sub>2</sub> Nanoparticles and Bisphenol A |
| title_full_unstemmed | Intestinal Microecology of Mice Exposed to TiO<sub>2</sub> Nanoparticles and Bisphenol A |
| title_short | Intestinal Microecology of Mice Exposed to TiO<sub>2</sub> Nanoparticles and Bisphenol A |
| title_sort | intestinal microecology of mice exposed to tio sub 2 sub nanoparticles and bisphenol a |
| topic | TiO<sub>2</sub> NPs BPA 16S rDNA faecal metabolomic |
| url | https://www.mdpi.com/2304-8158/11/12/1696 |
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