Effects of Bupleurum extract on blood metabolism, antioxidant status and immune function in heat-stressed dairy cows
This experiment was conducted to evaluate the effects of Bupleurum extract (BE) on blood metabolites, antioxidant status, and immune function in dairy cows under heat stress. Forty lactating Holstein cows were randomly assigned to 1 of 4 treatments. The treatments consisted of 0, 0.25, 0.5, and 1.0...
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| Format: | Article |
| Language: | English |
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Elsevier
2018-03-01
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| Series: | Journal of Integrative Agriculture |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S209531191761801X |
| _version_ | 1818438904438587392 |
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| author | Jian-bo CHENG Cai-yun FAN Xian-zhi SUN Jia-qi WANG Nan ZHENG Xing-kai ZHANG Jun-jie QIN Xiu-min WANG |
| author_facet | Jian-bo CHENG Cai-yun FAN Xian-zhi SUN Jia-qi WANG Nan ZHENG Xing-kai ZHANG Jun-jie QIN Xiu-min WANG |
| author_sort | Jian-bo CHENG |
| collection | DOAJ |
| description | This experiment was conducted to evaluate the effects of Bupleurum extract (BE) on blood metabolites, antioxidant status, and immune function in dairy cows under heat stress. Forty lactating Holstein cows were randomly assigned to 1 of 4 treatments. The treatments consisted of 0, 0.25, 0.5, and 1.0 g of BE kg−1 dry matter. Supplementation with BE decreased (P<0.05) blood urea nitrogen (BUN) contents and increased blood total protein (TP) and albumin (ALB) levels compared with control cows, but it had no effects (P>0.05) on blood glucose (GLU), nonesterified fatty acid (NEFA), total triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C). Compared with control cows, cows fed BE had higher (P<0.05) superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity. However, supplementation with BE had no effect (P>0.05) on total antioxidant capacity (T-AOC) or malondialdehyde (MDA) levels. The immunoglobulin (Ig) A and G contents increased (P<0.05) in cows fed 0.25 or 0.5 g of BE kg−1. Interleukin (IL)-2 and IL-4 levels were higher (P<0.05) in cows fed 0.5 and 1.0 g of BE kg−1, and IL-6 was significantly elevated (P<0.05) in cows fed 0.5 g of BE kg−1. There were no treatment effects (P>0.05) on the CD4+ and CD8+ T lymphocyte ratios, CD4+/CD8+ ratio, or tumor necrosis factor-α (TNF-α) level among the groups. These findings suggest that BE supplementation may improve protein metabolism, in addition to enhancing antioxidant activity and immune function in heat-stressed dairy cows. |
| first_indexed | 2024-12-14T17:47:59Z |
| format | Article |
| id | doaj.art-6d3f2a89d96b4a58b93ca7131703e25f |
| institution | Directory Open Access Journal |
| issn | 2095-3119 |
| language | English |
| last_indexed | 2024-12-14T17:47:59Z |
| publishDate | 2018-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Integrative Agriculture |
| spelling | doaj.art-6d3f2a89d96b4a58b93ca7131703e25f2022-12-21T22:52:43ZengElsevierJournal of Integrative Agriculture2095-31192018-03-01173657663Effects of Bupleurum extract on blood metabolism, antioxidant status and immune function in heat-stressed dairy cowsJian-bo CHENG0Cai-yun FAN1Xian-zhi SUN2Jia-qi WANG3Nan ZHENG4Xing-kai ZHANG5Jun-jie QIN6Xiu-min WANG7College of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, P.R.China; CHENG Jian-boCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, P.R.ChinaCollege of Animal Science and Technology, Anhui Agricultural University, Hefei 230036, P.R.ChinaLaboratory of Quality and Safety Risk Assessment for Dairy Products of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.ChinaLaboratory of Quality and Safety Risk Assessment for Dairy Products of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China; State Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R.China; Correspondence ZHENG Nan, Tel: +86-10-62816069, Fax: +86-10-62897587Shanghai Bright Holstan Co., Ltd., Shanghai 200436, P.R.ChinaBeijing Centre Biology Co., Ltd., Beijing 102206, P.R.ChinaBeijing Centre Biology Co., Ltd., Beijing 102206, P.R.ChinaThis experiment was conducted to evaluate the effects of Bupleurum extract (BE) on blood metabolites, antioxidant status, and immune function in dairy cows under heat stress. Forty lactating Holstein cows were randomly assigned to 1 of 4 treatments. The treatments consisted of 0, 0.25, 0.5, and 1.0 g of BE kg−1 dry matter. Supplementation with BE decreased (P<0.05) blood urea nitrogen (BUN) contents and increased blood total protein (TP) and albumin (ALB) levels compared with control cows, but it had no effects (P>0.05) on blood glucose (GLU), nonesterified fatty acid (NEFA), total triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C). Compared with control cows, cows fed BE had higher (P<0.05) superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activity. However, supplementation with BE had no effect (P>0.05) on total antioxidant capacity (T-AOC) or malondialdehyde (MDA) levels. The immunoglobulin (Ig) A and G contents increased (P<0.05) in cows fed 0.25 or 0.5 g of BE kg−1. Interleukin (IL)-2 and IL-4 levels were higher (P<0.05) in cows fed 0.5 and 1.0 g of BE kg−1, and IL-6 was significantly elevated (P<0.05) in cows fed 0.5 g of BE kg−1. There were no treatment effects (P>0.05) on the CD4+ and CD8+ T lymphocyte ratios, CD4+/CD8+ ratio, or tumor necrosis factor-α (TNF-α) level among the groups. These findings suggest that BE supplementation may improve protein metabolism, in addition to enhancing antioxidant activity and immune function in heat-stressed dairy cows.http://www.sciencedirect.com/science/article/pii/S209531191761801XBupleurum extractblood metabolitesheat stressdairy cows |
| spellingShingle | Jian-bo CHENG Cai-yun FAN Xian-zhi SUN Jia-qi WANG Nan ZHENG Xing-kai ZHANG Jun-jie QIN Xiu-min WANG Effects of Bupleurum extract on blood metabolism, antioxidant status and immune function in heat-stressed dairy cows Journal of Integrative Agriculture Bupleurum extract blood metabolites heat stress dairy cows |
| title | Effects of Bupleurum extract on blood metabolism, antioxidant status and immune function in heat-stressed dairy cows |
| title_full | Effects of Bupleurum extract on blood metabolism, antioxidant status and immune function in heat-stressed dairy cows |
| title_fullStr | Effects of Bupleurum extract on blood metabolism, antioxidant status and immune function in heat-stressed dairy cows |
| title_full_unstemmed | Effects of Bupleurum extract on blood metabolism, antioxidant status and immune function in heat-stressed dairy cows |
| title_short | Effects of Bupleurum extract on blood metabolism, antioxidant status and immune function in heat-stressed dairy cows |
| title_sort | effects of bupleurum extract on blood metabolism antioxidant status and immune function in heat stressed dairy cows |
| topic | Bupleurum extract blood metabolites heat stress dairy cows |
| url | http://www.sciencedirect.com/science/article/pii/S209531191761801X |
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