Succinate dehydrogenase variants in paraganglioma: why are B subunit variants ‘bad’?

Succinate dehydrogenase variants in paraganglioma: why are B subunit variants ‘bad’?

Mutations that predispose to familial pheochromocytoma and paraganglioma include inherited variants in the four genes (SDHA, SDHB, SDHC and SDHD) encoding subunits of succinate dehydrogenase (SDH), an enzyme of the mitochondrial tricarboxylic acid cycle and complex II of the electron transport chain...

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Bibliographic Details
Main Authors:	Lucinda M Gruber, Steven N Hart, Louis James Maher III
Format:	Article
Language:	English
Published:	Bioscientifica 2023-04-01
Series:	Endocrine Oncology
Subjects:	succinate dehydrogenase paraganglioma pheochromocytoma missense variant pathogenicity
Online Access:	https://eo.bioscientifica.com/view/journals/eo/3/1/EO-22-0093.xml

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