Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions
The development of phase-shift droplets has broadened the scope of ultrasound-based biomedical applications. When subjected to sufficient acoustic pressures, the perfluorocarbon phase in phase-shift droplets undergoes a phase-transition to a gaseous state. This phenomenon, termed acoustic droplet va...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Zeitschrift für Medizinische Physik |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0939388923000041 |
| _version_ | 1797385285419401216 |
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| author | Mitra Aliabouzar Oliver D. Kripfgans J. Brian Fowlkes Mario L. Fabiilli |
| author_facet | Mitra Aliabouzar Oliver D. Kripfgans J. Brian Fowlkes Mario L. Fabiilli |
| author_sort | Mitra Aliabouzar |
| collection | DOAJ |
| description | The development of phase-shift droplets has broadened the scope of ultrasound-based biomedical applications. When subjected to sufficient acoustic pressures, the perfluorocarbon phase in phase-shift droplets undergoes a phase-transition to a gaseous state. This phenomenon, termed acoustic droplet vaporization (ADV), has been the subject of substantial research over the last two decades with great progress made in design of phase-shift droplets, fundamental physics of bubble nucleation and dynamics, and applications. Here, we review experimental approaches, carried out via high-speed microscopy, as well as theoretical models that have been proposed to study the fundamental physics of ADV including vapor nucleation and ADV-induced bubble dynamics. In addition, we highlight new developments of ADV in tissue regeneration, which is a relatively recently exploited application. We conclude this review with future opportunities of ADV for advanced applications such as in situ microrheology and pressure estimation. |
| first_indexed | 2024-03-08T21:51:58Z |
| format | Article |
| id | doaj.art-6d4869c04a154a25ab6e35e0dcfc21c6 |
| institution | Directory Open Access Journal |
| issn | 0939-3889 |
| language | English |
| last_indexed | 2024-03-08T21:51:58Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Zeitschrift für Medizinische Physik |
| spelling | doaj.art-6d4869c04a154a25ab6e35e0dcfc21c62023-12-20T07:33:28ZengElsevierZeitschrift für Medizinische Physik0939-38892023-08-01333387406Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directionsMitra Aliabouzar0Oliver D. Kripfgans1J. Brian Fowlkes2Mario L. Fabiilli3Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA; Corresponding author.Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Applied Physics Program, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USADepartment of Radiology, University of Michigan, Ann Arbor, MI, USA; Applied Physics Program, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USADepartment of Radiology, University of Michigan, Ann Arbor, MI, USA; Applied Physics Program, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USAThe development of phase-shift droplets has broadened the scope of ultrasound-based biomedical applications. When subjected to sufficient acoustic pressures, the perfluorocarbon phase in phase-shift droplets undergoes a phase-transition to a gaseous state. This phenomenon, termed acoustic droplet vaporization (ADV), has been the subject of substantial research over the last two decades with great progress made in design of phase-shift droplets, fundamental physics of bubble nucleation and dynamics, and applications. Here, we review experimental approaches, carried out via high-speed microscopy, as well as theoretical models that have been proposed to study the fundamental physics of ADV including vapor nucleation and ADV-induced bubble dynamics. In addition, we highlight new developments of ADV in tissue regeneration, which is a relatively recently exploited application. We conclude this review with future opportunities of ADV for advanced applications such as in situ microrheology and pressure estimation.http://www.sciencedirect.com/science/article/pii/S0939388923000041Acoustic droplet vaporizationBubble dynamicsPhase-shift dropletsUltrasoundMicrorheologyHigh-speed microscopy |
| spellingShingle | Mitra Aliabouzar Oliver D. Kripfgans J. Brian Fowlkes Mario L. Fabiilli Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions Zeitschrift für Medizinische Physik Acoustic droplet vaporization Bubble dynamics Phase-shift droplets Ultrasound Microrheology High-speed microscopy |
| title | Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions |
| title_full | Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions |
| title_fullStr | Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions |
| title_full_unstemmed | Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions |
| title_short | Bubble nucleation and dynamics in acoustic droplet vaporization: a review of concepts, applications, and new directions |
| title_sort | bubble nucleation and dynamics in acoustic droplet vaporization a review of concepts applications and new directions |
| topic | Acoustic droplet vaporization Bubble dynamics Phase-shift droplets Ultrasound Microrheology High-speed microscopy |
| url | http://www.sciencedirect.com/science/article/pii/S0939388923000041 |
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