Research progress in toxicological effects and mechanism of aflatoxin B1 toxin
Fungal contamination of animal feed can severely affect the health of farm animals, and result in considerable economic losses. Certain filamentous fungi or molds produce toxic secondary metabolites known as mycotoxins, of which aflatoxins (AFTs) are considered the most critical dietary risk factor...
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PeerJ Inc.
2022-08-01
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| Online Access: | https://peerj.com/articles/13850.pdf |
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| author | Congcong Li Xiangdong Liu Jiao Wu Xiangbo Ji Qiuliang Xu |
| author_facet | Congcong Li Xiangdong Liu Jiao Wu Xiangbo Ji Qiuliang Xu |
| author_sort | Congcong Li |
| collection | DOAJ |
| description | Fungal contamination of animal feed can severely affect the health of farm animals, and result in considerable economic losses. Certain filamentous fungi or molds produce toxic secondary metabolites known as mycotoxins, of which aflatoxins (AFTs) are considered the most critical dietary risk factor for both humans and animals. AFTs are ubiquitous in the environment, soil, and food crops, and aflatoxin B1(AFB1) has been identified by the World Health Organization (WHO) as one of the most potent natural group 1A carcinogen. We reviewed the literature on the toxic effects of AFB1 in humans and animals along with its toxicokinetic properties. The damage induced by AFB1 in cells and tissues is mainly achieved through cell cycle arrest and inhibition of cell proliferation, and the induction of apoptosis, oxidative stress, endoplasmic reticulum (ER) stress and autophagy. In addition, numerous coding genes and non-coding RNAs have been identified that regulate AFB1 toxicity. This review is a summary of the current research on the complexity of AFB1 toxicity, and provides insights into the molecular mechanisms as well as the phenotypic characteristics. |
| first_indexed | 2024-03-09T05:13:02Z |
| format | Article |
| id | doaj.art-6d4a4df31b8846bcb99d9f4141d9af53 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T05:13:02Z |
| publishDate | 2022-08-01 |
| publisher | PeerJ Inc. |
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| spelling | doaj.art-6d4a4df31b8846bcb99d9f4141d9af532023-12-03T12:48:00ZengPeerJ Inc.PeerJ2167-83592022-08-0110e1385010.7717/peerj.13850Research progress in toxicological effects and mechanism of aflatoxin B1 toxinCongcong Li0Xiangdong Liu1Jiao Wu2Xiangbo Ji3Qiuliang Xu4College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou, Henan, ChinaHuazhong Agricultural University, Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education & Key Lab of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs, Wuhan, Hubei, ChinaCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou, Henan, ChinaHenan University of Animal Husbandry and Economy, Henan Key Laboratory of Unconventional Feed Resources Innovative Utilization, Zhengzhou, Henan, ChinaCollege of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou, Henan, ChinaFungal contamination of animal feed can severely affect the health of farm animals, and result in considerable economic losses. Certain filamentous fungi or molds produce toxic secondary metabolites known as mycotoxins, of which aflatoxins (AFTs) are considered the most critical dietary risk factor for both humans and animals. AFTs are ubiquitous in the environment, soil, and food crops, and aflatoxin B1(AFB1) has been identified by the World Health Organization (WHO) as one of the most potent natural group 1A carcinogen. We reviewed the literature on the toxic effects of AFB1 in humans and animals along with its toxicokinetic properties. The damage induced by AFB1 in cells and tissues is mainly achieved through cell cycle arrest and inhibition of cell proliferation, and the induction of apoptosis, oxidative stress, endoplasmic reticulum (ER) stress and autophagy. In addition, numerous coding genes and non-coding RNAs have been identified that regulate AFB1 toxicity. This review is a summary of the current research on the complexity of AFB1 toxicity, and provides insights into the molecular mechanisms as well as the phenotypic characteristics.https://peerj.com/articles/13850.pdfMycotoxinsAflatoxin B1ToxicitiesMechanismsRegulation |
| spellingShingle | Congcong Li Xiangdong Liu Jiao Wu Xiangbo Ji Qiuliang Xu Research progress in toxicological effects and mechanism of aflatoxin B1 toxin PeerJ Mycotoxins Aflatoxin B1 Toxicities Mechanisms Regulation |
| title | Research progress in toxicological effects and mechanism of aflatoxin B1 toxin |
| title_full | Research progress in toxicological effects and mechanism of aflatoxin B1 toxin |
| title_fullStr | Research progress in toxicological effects and mechanism of aflatoxin B1 toxin |
| title_full_unstemmed | Research progress in toxicological effects and mechanism of aflatoxin B1 toxin |
| title_short | Research progress in toxicological effects and mechanism of aflatoxin B1 toxin |
| title_sort | research progress in toxicological effects and mechanism of aflatoxin b1 toxin |
| topic | Mycotoxins Aflatoxin B1 Toxicities Mechanisms Regulation |
| url | https://peerj.com/articles/13850.pdf |
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