TDP-43 pathology is associated with increased tau burdens and seeding

TDP-43 pathology is associated with increased tau burdens and seeding

Abstract Background Most Alzheimer’s Disease (AD) cases also exhibit limbic predominant age-related TDP-43 encephalopathy neuropathological changes (LATE-NC), besides amyloid-β plaques and neurofibrillary tangles (NFTs) containing hyperphosphorylated tau (p-tau). LATE-NC is characterized by cytoplas...

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Main Authors: Sandra O. Tomé, Grigoria Tsaka, Alicja Ronisz, Simona Ospitalieri, Klara Gawor, Luis Aragão Gomes, Markus Otto, Christine A. F. von Arnim, Philip Van Damme, Ludo Van Den Bosch, Estifanos Ghebremedhin, Celeste Laureyssen, Kristel Sleegers, Rik Vandenberghe, Frederic Rousseau, Joost Schymkowitz, Dietmar Rudolf Thal
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s Disease
TDP-43
LATE-NC
Co-pathologies seeding
Tau
Protein aggregation
Online Access:https://doi.org/10.1186/s13024-023-00653-0

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