CANCER STEM CELL BIOLOGY
Cancer is becoming the leading cause of death all around the world. To develop better therapeutic options against cancer, we need a thorough understanding of tumor development and dissemination. As our knowledge increases, it becomes apparent that cancer is a very complex disease and this complexity...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Trakya University
2019-02-01
|
| Series: | Trakya University Journal of Natural Sciences |
| Subjects: | |
| Online Access: | https://dergipark.org.tr/en/download/article-file/636904 |
| _version_ | 1827767532628475904 |
|---|---|
| author | Serkan İsmail Göktuna Tieu Lan Chau Erta Xhafa |
| author_facet | Serkan İsmail Göktuna Tieu Lan Chau Erta Xhafa |
| author_sort | Serkan İsmail Göktuna |
| collection | DOAJ |
| description | Cancer is becoming the leading cause of death
all around the world. To develop better therapeutic options against cancer, we
need a thorough understanding of tumor development and dissemination. As our
knowledge increases, it becomes apparent that cancer is a very complex disease
and this complexity is partially due to the great level of heterogeneity even
within the same tumor mass. Therefore, there is a pressing need to decipher
complex regulations and interactions of the tumor cells that lead to different
hierarchies. Concepts of tumor-initiating and self-renewing stem cell have long
been proposed to explain the emergence of a vast number of progenies within
monoclonal neoplastic growth. It is now known that cancer stem cells which are
found in many cancers have many roles in tumor development and dissemination.
Many fascinating properties of cancer stem cells draw further attention to
clarify their involvement in tumor cell plasticity, epithelial to mesenchymal
transition, chemotherapy resistance and to develop therapeutic strategies for
their targeting. Here we summarized recent efforts to illustrate the progress in
our understanding of the biology of cancer stem cells. |
| first_indexed | 2024-03-11T11:59:40Z |
| format | Article |
| id | doaj.art-6d4df4caaca246fe90ee225e3c751685 |
| institution | Directory Open Access Journal |
| issn | 2528-9691 |
| language | English |
| last_indexed | 2024-03-11T11:59:40Z |
| publishDate | 2019-02-01 |
| publisher | Trakya University |
| record_format | Article |
| series | Trakya University Journal of Natural Sciences |
| spelling | doaj.art-6d4df4caaca246fe90ee225e3c7516852023-11-08T07:27:57ZengTrakya UniversityTrakya University Journal of Natural Sciences2528-96912019-02-0120334410.23902/trkjnat.48357769CANCER STEM CELL BIOLOGYSerkan İsmail Göktuna0Tieu Lan Chau1Erta Xhafa2İHSAN DOĞRAMACI BİLKENT ÜNİVERSİTESİ, FEN FAKÜLTESİ, MOLEKÜLER BİYOLOJİ VE GENETİK BÖLÜMÜİHSAN DOĞRAMACI BİLKENT ÜNİVERSİTESİ, FEN FAKÜLTESİ, MOLEKÜLER BİYOLOJİ VE GENETİK BÖLÜMÜİHSAN DOĞRAMACI BİLKENT ÜNİVERSİTESİ, FEN FAKÜLTESİ, MOLEKÜLER BİYOLOJİ VE GENETİK BÖLÜMÜCancer is becoming the leading cause of death all around the world. To develop better therapeutic options against cancer, we need a thorough understanding of tumor development and dissemination. As our knowledge increases, it becomes apparent that cancer is a very complex disease and this complexity is partially due to the great level of heterogeneity even within the same tumor mass. Therefore, there is a pressing need to decipher complex regulations and interactions of the tumor cells that lead to different hierarchies. Concepts of tumor-initiating and self-renewing stem cell have long been proposed to explain the emergence of a vast number of progenies within monoclonal neoplastic growth. It is now known that cancer stem cells which are found in many cancers have many roles in tumor development and dissemination. Many fascinating properties of cancer stem cells draw further attention to clarify their involvement in tumor cell plasticity, epithelial to mesenchymal transition, chemotherapy resistance and to develop therapeutic strategies for their targeting. Here we summarized recent efforts to illustrate the progress in our understanding of the biology of cancer stem cells.https://dergipark.org.tr/en/download/article-file/636904cancer stem cellsdifferentiationplasticityclonal selectionlineage tracingand cancer therapy |
| spellingShingle | Serkan İsmail Göktuna Tieu Lan Chau Erta Xhafa CANCER STEM CELL BIOLOGY Trakya University Journal of Natural Sciences cancer stem cells differentiation plasticity clonal selection lineage tracing and cancer therapy |
| title | CANCER STEM CELL BIOLOGY |
| title_full | CANCER STEM CELL BIOLOGY |
| title_fullStr | CANCER STEM CELL BIOLOGY |
| title_full_unstemmed | CANCER STEM CELL BIOLOGY |
| title_short | CANCER STEM CELL BIOLOGY |
| title_sort | cancer stem cell biology |
| topic | cancer stem cells differentiation plasticity clonal selection lineage tracing and cancer therapy |
| url | https://dergipark.org.tr/en/download/article-file/636904 |
| work_keys_str_mv | AT serkanismailgoktuna cancerstemcellbiology AT tieulanchau cancerstemcellbiology AT ertaxhafa cancerstemcellbiology |