Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study.
BACKGROUND: Environmental and lifestyle factors regulate the expression and release of immune mediators. It has been hypothesised that ambient air pollution may be such an external factor and that the association between air pollution and impaired glucose metabolism may be attributable to inflammato...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3858363?pdf=render |
| _version_ | 1818701553226219520 |
|---|---|
| author | Tom Teichert Mohammad Vossoughi Andrea Vierkötter Dorothea Sugiri Tamara Schikowski Thomas Schulte Michael Roden Christian Luckhaus Christian Herder Ursula Krämer |
| author_facet | Tom Teichert Mohammad Vossoughi Andrea Vierkötter Dorothea Sugiri Tamara Schikowski Thomas Schulte Michael Roden Christian Luckhaus Christian Herder Ursula Krämer |
| author_sort | Tom Teichert |
| collection | DOAJ |
| description | BACKGROUND: Environmental and lifestyle factors regulate the expression and release of immune mediators. It has been hypothesised that ambient air pollution may be such an external factor and that the association between air pollution and impaired glucose metabolism may be attributable to inflammatory processes. Therefore, we assessed the associations between air pollution, circulating immune mediators and impaired glucose metabolism. METHODS: We analysed concentrations of 14 pro- and anti-inflammatory immune mediators as well as fasting glucose and insulin levels in plasma of 363 women from the Study on the influence of Air pollution on Lung function, Inflammation and Aging (SALIA, Germany). Exposure data for a group of pollutants such as nitrogen oxides (NO2, NOx) and different fractions of particulate matter were available for the participants' residences. We calculated the association between the pollutants and impaired glucose metabolism by multiple regression models. RESULTS: The study participants had a mean age of 74.1 (SD 2.6) years and 48% showed impaired glucose metabolism based on impaired fasting glucose or previously diagnosed type 2 diabetes. Only long-term exposure NO2 and NOx concentrations showed positive associations (NO2: OR 1.465, 95% CI 1.049-2.046, NOx: OR 1.409, 95% CI 1.010-1.967) per increased interquartile range of NO2 (14.65 µg/m(3)) or NOx (43.16 µg/m(3)), respectively, but statistical significance was lost after correction for multiple comparisons. Additional adjustment for circulating immune mediators or the use of anti-inflammatory medication had hardly any impact on the observed ORs. CONCLUSIONS: Our results suggest that exposure to nitrogen oxides may contribute to impaired glucose metabolism, but the associations did not reach statistical significance so that further studies with larger sample sizes are required to substantiate our findings. Our data do not preclude a role of inflammatory mechanisms in adipose or other tissues which may not be reflected by immune mediators in plasma. |
| first_indexed | 2024-12-17T15:22:40Z |
| format | Article |
| id | doaj.art-6d4ef110188f452599080989b3a16941 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-17T15:22:40Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6d4ef110188f452599080989b3a169412022-12-21T21:43:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01812e8304210.1371/journal.pone.0083042Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study.Tom TeichertMohammad VossoughiAndrea VierkötterDorothea SugiriTamara SchikowskiThomas SchulteMichael RodenChristian LuckhausChristian HerderUrsula KrämerBACKGROUND: Environmental and lifestyle factors regulate the expression and release of immune mediators. It has been hypothesised that ambient air pollution may be such an external factor and that the association between air pollution and impaired glucose metabolism may be attributable to inflammatory processes. Therefore, we assessed the associations between air pollution, circulating immune mediators and impaired glucose metabolism. METHODS: We analysed concentrations of 14 pro- and anti-inflammatory immune mediators as well as fasting glucose and insulin levels in plasma of 363 women from the Study on the influence of Air pollution on Lung function, Inflammation and Aging (SALIA, Germany). Exposure data for a group of pollutants such as nitrogen oxides (NO2, NOx) and different fractions of particulate matter were available for the participants' residences. We calculated the association between the pollutants and impaired glucose metabolism by multiple regression models. RESULTS: The study participants had a mean age of 74.1 (SD 2.6) years and 48% showed impaired glucose metabolism based on impaired fasting glucose or previously diagnosed type 2 diabetes. Only long-term exposure NO2 and NOx concentrations showed positive associations (NO2: OR 1.465, 95% CI 1.049-2.046, NOx: OR 1.409, 95% CI 1.010-1.967) per increased interquartile range of NO2 (14.65 µg/m(3)) or NOx (43.16 µg/m(3)), respectively, but statistical significance was lost after correction for multiple comparisons. Additional adjustment for circulating immune mediators or the use of anti-inflammatory medication had hardly any impact on the observed ORs. CONCLUSIONS: Our results suggest that exposure to nitrogen oxides may contribute to impaired glucose metabolism, but the associations did not reach statistical significance so that further studies with larger sample sizes are required to substantiate our findings. Our data do not preclude a role of inflammatory mechanisms in adipose or other tissues which may not be reflected by immune mediators in plasma.http://europepmc.org/articles/PMC3858363?pdf=render |
| spellingShingle | Tom Teichert Mohammad Vossoughi Andrea Vierkötter Dorothea Sugiri Tamara Schikowski Thomas Schulte Michael Roden Christian Luckhaus Christian Herder Ursula Krämer Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study. PLoS ONE |
| title | Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study. |
| title_full | Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study. |
| title_fullStr | Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study. |
| title_full_unstemmed | Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study. |
| title_short | Association between traffic-related air pollution, subclinical inflammation and impaired glucose metabolism: results from the SALIA study. |
| title_sort | association between traffic related air pollution subclinical inflammation and impaired glucose metabolism results from the salia study |
| url | http://europepmc.org/articles/PMC3858363?pdf=render |
| work_keys_str_mv | AT tomteichert associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy AT mohammadvossoughi associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy AT andreavierkotter associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy AT dorotheasugiri associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy AT tamaraschikowski associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy AT thomasschulte associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy AT michaelroden associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy AT christianluckhaus associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy AT christianherder associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy AT ursulakramer associationbetweentrafficrelatedairpollutionsubclinicalinflammationandimpairedglucosemetabolismresultsfromthesaliastudy |