The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis
Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can p...
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MDPI AG
2021-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/11/1979 |
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| author | Chia-Te Kung Chih-Min Su Sheng-Yuan Hsiao Fu-Cheng Chen Yun-Ru Lai Chih-Cheng Huang Cheng-Hsien Lu |
| author_facet | Chia-Te Kung Chih-Min Su Sheng-Yuan Hsiao Fu-Cheng Chen Yun-Ru Lai Chih-Cheng Huang Cheng-Hsien Lu |
| author_sort | Chia-Te Kung |
| collection | DOAJ |
| description | Increased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can predict therapeutic outcomes. One hundred and fifty-five patients prospectively underwent blood samples including biochemical data, sTREM-1, and biomarkers on endothelial dysfunction as well as clinical severity index examinations. Blood samples from Days 1, 4, and 7 after admission were checked. For comparison, 50 healthy subjects were selected as healthy control. Those patients who had sepsis had significantly higher sTREM-1 levels than those of healthy control. sTREM-1 levels positively correlated with biomarkers for endothelial dysfunction (ICAM-1, VCAM-1, and E-selectin) and lactate level as well as clinical severity index (maximum 24 h APACHE score and Sequential Organ Failure Assessment (SOFA) score) upon admission. sTREM-1 concentrations were significantly higher from Day 1 to Day 7 in the non-survivors than in the survivors. A stepwise logistic regression analysis showed only sTREM-1 level and maximum 24 h SOFA score upon admission were significantly associated with fatality. Area under the receiver operating characteristic curve analysis for the diagnostic accuracy of sTREM-1 in sepsis-related fatality gave a value of 0.726, with a cutoff value of 384.6 pg/mL (sensitivity = 80.8% and specificity = 61.5%). sTREM-1 level may be valuable in auxiliary diagnosis, and it can serve as a useful biomarker as a screening service and follow-up therapeutic outcomes in sepsis. |
| first_indexed | 2024-03-10T05:34:28Z |
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| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T05:34:28Z |
| publishDate | 2021-10-01 |
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| series | Diagnostics |
| spelling | doaj.art-6d4f7d7e1b9b4629ba439d5656c790ca2023-11-22T23:00:35ZengMDPI AGDiagnostics2075-44182021-10-011111197910.3390/diagnostics11111979The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with SepsisChia-Te Kung0Chih-Min Su1Sheng-Yuan Hsiao2Fu-Cheng Chen3Yun-Ru Lai4Chih-Cheng Huang5Cheng-Hsien Lu6Department of Emergency Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Emergency Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Emergency Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanDepartment of Emergency Medicine, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanNeurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanNeurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanNeurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung 833, TaiwanIncreased soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) levels have been reported in patients with sepsis. We tested the hypotheses that serum sTREM-1 levels increase in the early phase of sepsis and decrease after sepsis under appropriate treatment and that sTREM-1 levels can predict therapeutic outcomes. One hundred and fifty-five patients prospectively underwent blood samples including biochemical data, sTREM-1, and biomarkers on endothelial dysfunction as well as clinical severity index examinations. Blood samples from Days 1, 4, and 7 after admission were checked. For comparison, 50 healthy subjects were selected as healthy control. Those patients who had sepsis had significantly higher sTREM-1 levels than those of healthy control. sTREM-1 levels positively correlated with biomarkers for endothelial dysfunction (ICAM-1, VCAM-1, and E-selectin) and lactate level as well as clinical severity index (maximum 24 h APACHE score and Sequential Organ Failure Assessment (SOFA) score) upon admission. sTREM-1 concentrations were significantly higher from Day 1 to Day 7 in the non-survivors than in the survivors. A stepwise logistic regression analysis showed only sTREM-1 level and maximum 24 h SOFA score upon admission were significantly associated with fatality. Area under the receiver operating characteristic curve analysis for the diagnostic accuracy of sTREM-1 in sepsis-related fatality gave a value of 0.726, with a cutoff value of 384.6 pg/mL (sensitivity = 80.8% and specificity = 61.5%). sTREM-1 level may be valuable in auxiliary diagnosis, and it can serve as a useful biomarker as a screening service and follow-up therapeutic outcomes in sepsis.https://www.mdpi.com/2075-4418/11/11/1979hospital mortalitysTREM-1sepsisoutcome |
| spellingShingle | Chia-Te Kung Chih-Min Su Sheng-Yuan Hsiao Fu-Cheng Chen Yun-Ru Lai Chih-Cheng Huang Cheng-Hsien Lu The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis Diagnostics hospital mortality sTREM-1 sepsis outcome |
| title | The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis |
| title_full | The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis |
| title_fullStr | The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis |
| title_full_unstemmed | The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis |
| title_short | The Prognostic Value of Serum Soluble TREM-1 on Outcome in Adult Patients with Sepsis |
| title_sort | prognostic value of serum soluble trem 1 on outcome in adult patients with sepsis |
| topic | hospital mortality sTREM-1 sepsis outcome |
| url | https://www.mdpi.com/2075-4418/11/11/1979 |
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