Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease
Adherence to healthy lifestyles is associated with reduced risk of coronary heart disease (CHD), but uncertainty persists about the underlying lipid pathway. In a case–control study of 4681 participants nested in the prospective China Kadoorie Biobank, 61 lipidomic markers in baseline plasma were me...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2021-02-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/60999 |
| _version_ | 1811202947052208128 |
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| author | Jiahui Si Jiachen Li Canqing Yu Yu Guo Zheng Bian Iona Millwood Ling Yang Robin Walters Yiping Chen Huaidong Du Li Yin Jianwei Chen Junshi Chen Zhengming Chen Liming Li Liming Liang Jun Lv |
| author_facet | Jiahui Si Jiachen Li Canqing Yu Yu Guo Zheng Bian Iona Millwood Ling Yang Robin Walters Yiping Chen Huaidong Du Li Yin Jianwei Chen Junshi Chen Zhengming Chen Liming Li Liming Liang Jun Lv |
| author_sort | Jiahui Si |
| collection | DOAJ |
| description | Adherence to healthy lifestyles is associated with reduced risk of coronary heart disease (CHD), but uncertainty persists about the underlying lipid pathway. In a case–control study of 4681 participants nested in the prospective China Kadoorie Biobank, 61 lipidomic markers in baseline plasma were measured by targeted nuclear magnetic resonance spectroscopy. Baseline lifestyles included smoking, alcohol consumption, dietary habit, physical activity, and adiposity levels. Genetic instrument was used to mimic the lipid-lowering effect of statins. We found that 35 lipid metabolites showed statistically significant mediation effects in the pathway from healthy lifestyles to CHD reduction, including very low-density lipoprotein (VLDL) particles and their cholesterol, large-sized high-density lipoprotein (HDL) particle and its cholesterol, and triglyceride in almost all lipoprotein subfractions. The statins genetic score was associated with reduced intermediate- and low-density lipoprotein, but weak or no association with VLDL and HDL. Lifestyle interventions and statins may improve different components of the lipid profile. |
| first_indexed | 2024-04-12T02:46:15Z |
| format | Article |
| id | doaj.art-6d50e350d71b4d44b93421bcbf0d7f3a |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:46:15Z |
| publishDate | 2021-02-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-6d50e350d71b4d44b93421bcbf0d7f3a2022-12-22T03:51:09ZengeLife Sciences Publications LtdeLife2050-084X2021-02-011010.7554/eLife.60999Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart diseaseJiahui Si0Jiachen Li1Canqing Yu2Yu Guo3Zheng Bian4Iona Millwood5Ling Yang6Robin Walters7Yiping Chen8Huaidong Du9Li Yin10Jianwei Chen11Junshi Chen12Zhengming Chen13Liming Li14Liming Liang15Jun Lv16https://orcid.org/0000-0001-7916-3870Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Departments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United StatesDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Peking University Institute of Public Health & Emergency Preparedness, Beijing, ChinaChinese Academy of Medical Sciences, Beijing, ChinaChinese Academy of Medical Sciences, Beijing, ChinaMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United KingdomMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United KingdomMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United KingdomMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United KingdomMedical Research Council Population Health Research Unit at the University of Oxford, Oxford, United Kingdom; Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United KingdomNCDs Prevention and Control Department, Hunan Center for Disease Control & Prevention, Changsha, ChinaLiuyang Center for Disease Control & Prevention, Liuyang, Hunan, ChinaChina National Center for Food Safety Risk Assessment, Beijing, ChinaClinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, United KingdomDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Peking University Institute of Public Health & Emergency Preparedness, Beijing, ChinaDepartments of Epidemiology and Biostatistics, Harvard T.H. Chan School of Public Health, Boston, United StatesDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China; Peking University Institute of Public Health & Emergency Preparedness, Beijing, China; Key Laboratory of Molecular Cardiovascular Sciences (Peking University), Ministry of Education, Beijing, ChinaAdherence to healthy lifestyles is associated with reduced risk of coronary heart disease (CHD), but uncertainty persists about the underlying lipid pathway. In a case–control study of 4681 participants nested in the prospective China Kadoorie Biobank, 61 lipidomic markers in baseline plasma were measured by targeted nuclear magnetic resonance spectroscopy. Baseline lifestyles included smoking, alcohol consumption, dietary habit, physical activity, and adiposity levels. Genetic instrument was used to mimic the lipid-lowering effect of statins. We found that 35 lipid metabolites showed statistically significant mediation effects in the pathway from healthy lifestyles to CHD reduction, including very low-density lipoprotein (VLDL) particles and their cholesterol, large-sized high-density lipoprotein (HDL) particle and its cholesterol, and triglyceride in almost all lipoprotein subfractions. The statins genetic score was associated with reduced intermediate- and low-density lipoprotein, but weak or no association with VLDL and HDL. Lifestyle interventions and statins may improve different components of the lipid profile.https://elifesciences.org/articles/60999coronary heart diseaselifestylelipidomicsgeneticsmediation effect |
| spellingShingle | Jiahui Si Jiachen Li Canqing Yu Yu Guo Zheng Bian Iona Millwood Ling Yang Robin Walters Yiping Chen Huaidong Du Li Yin Jianwei Chen Junshi Chen Zhengming Chen Liming Li Liming Liang Jun Lv Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease eLife coronary heart disease lifestyle lipidomics genetics mediation effect |
| title | Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease |
| title_full | Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease |
| title_fullStr | Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease |
| title_full_unstemmed | Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease |
| title_short | Improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease |
| title_sort | improved lipidomic profile mediates the effects of adherence to healthy lifestyles on coronary heart disease |
| topic | coronary heart disease lifestyle lipidomics genetics mediation effect |
| url | https://elifesciences.org/articles/60999 |
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