Severity Index of Neonatal Septicemia in Neonatal Intensive Care units Using Score for Neonatal Acute Physiology-II
Background: This study aimed to evaluate the competence of the score for neonatal acute physiology (SNAP-II) as a tool to anticipate morbidity and mortality of neonates with early or late sepsis in neonatal intensive care units (NICUs). Methods: This prospective cohort study was conducted on all neo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2021-07-01
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| Series: | Iranian Journal of Neonatology |
| Subjects: | |
| Online Access: | https://ijn.mums.ac.ir/article_18481_93723c2ce7cda7d9f4299c0b44b69c21.pdf |
| _version_ | 1819242997563260928 |
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| author | Lamiaa Mohsen Mourad Ramzy Nermin Mohamed Ahmed Youssef Amira Hegazy Dina Akmal |
| author_facet | Lamiaa Mohsen Mourad Ramzy Nermin Mohamed Ahmed Youssef Amira Hegazy Dina Akmal |
| author_sort | Lamiaa Mohsen |
| collection | DOAJ |
| description | Background: This study aimed to evaluate the competence of the score for neonatal acute physiology (SNAP-II) as a tool to anticipate morbidity and mortality of neonates with early or late sepsis in neonatal intensive care units (NICUs).
Methods: This prospective cohort study was conducted on all neonates of > 32 weeks with sepsis in tertiary NICUs at Cairo University Children Hospital and El Galaa Hospital For Armed Forces Officers Families, Cairo, Egypt, within May-October 2019. The eligible samples consisted of 100 neonates with septicemia who met inclusion and exclusion criteria and were enrolled. the score for neonatal acute physiology-II was calculated within 24 h of sepsis onset and followed up for 2 weeks for mortality and organ dysfunction (OD). The collected data were analyzed in SPSS software (version 25).
Results: It was revealed thatSNAP-II was significantly higher in neonates who passed away, compared to the survived neonates (46±17 vs. 12±10, respectively; P<0.001). Moreover, SNAP-II was significantly higher in neonates who developed OD within 14 days of sepsis onset, compared to those without OD (37±17 vs. 9±7, respectively; P<0.001). The score for neonatal acute physiology-II at 14.5 was considered the best cut-off point in predicting OD with a sensitivity of 100%, positive predictive value of 70.4%, specificity of 81.2%, and negative predictive value of 100%. In addition, SNAP-II at 23.5 was considered the best cut-off point in predicting overall mortality with 100% sensitivity, 58.6% PPV, 85.5% specificity, and 100% NPV.
Conclusion: Higher SNAP-II within 24 h of the early- or late-onset neonatal sepsis was a reliable predictor of OD and death. |
| first_indexed | 2024-12-23T14:48:42Z |
| format | Article |
| id | doaj.art-6d5166dbc8e34d28a2946a3dedbf427e |
| institution | Directory Open Access Journal |
| issn | 2251-7510 2322-2158 |
| language | English |
| last_indexed | 2024-12-23T14:48:42Z |
| publishDate | 2021-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Neonatology |
| spelling | doaj.art-6d5166dbc8e34d28a2946a3dedbf427e2022-12-21T17:43:02ZengMashhad University of Medical SciencesIranian Journal of Neonatology2251-75102322-21582021-07-01123323910.22038/ijn.2021.55404.206118481Severity Index of Neonatal Septicemia in Neonatal Intensive Care units Using Score for Neonatal Acute Physiology-IILamiaa Mohsen0Mourad Ramzy1Nermin Mohamed2Ahmed Youssef3Amira Hegazy4Dina Akmal5Faculty of Medicine, Cairo University, Cairo, EgyptMilitary Medical Academy, EgyptFaculty of Medicine, Cairo University, Cairo, EgyptConsultant of Pediatrics, Ministry of Health, EgyptPublic Health and Community Medicine Department, Faculty of Medicine, Cairo University, Cairo, EgyptFaculty of Medicine, Cairo University, Cairo, EgyptBackground: This study aimed to evaluate the competence of the score for neonatal acute physiology (SNAP-II) as a tool to anticipate morbidity and mortality of neonates with early or late sepsis in neonatal intensive care units (NICUs). Methods: This prospective cohort study was conducted on all neonates of > 32 weeks with sepsis in tertiary NICUs at Cairo University Children Hospital and El Galaa Hospital For Armed Forces Officers Families, Cairo, Egypt, within May-October 2019. The eligible samples consisted of 100 neonates with septicemia who met inclusion and exclusion criteria and were enrolled. the score for neonatal acute physiology-II was calculated within 24 h of sepsis onset and followed up for 2 weeks for mortality and organ dysfunction (OD). The collected data were analyzed in SPSS software (version 25). Results: It was revealed thatSNAP-II was significantly higher in neonates who passed away, compared to the survived neonates (46±17 vs. 12±10, respectively; P<0.001). Moreover, SNAP-II was significantly higher in neonates who developed OD within 14 days of sepsis onset, compared to those without OD (37±17 vs. 9±7, respectively; P<0.001). The score for neonatal acute physiology-II at 14.5 was considered the best cut-off point in predicting OD with a sensitivity of 100%, positive predictive value of 70.4%, specificity of 81.2%, and negative predictive value of 100%. In addition, SNAP-II at 23.5 was considered the best cut-off point in predicting overall mortality with 100% sensitivity, 58.6% PPV, 85.5% specificity, and 100% NPV. Conclusion: Higher SNAP-II within 24 h of the early- or late-onset neonatal sepsis was a reliable predictor of OD and death.https://ijn.mums.ac.ir/article_18481_93723c2ce7cda7d9f4299c0b44b69c21.pdfmortalityneonatesorgan dysfunctionsepsissnap-ii |
| spellingShingle | Lamiaa Mohsen Mourad Ramzy Nermin Mohamed Ahmed Youssef Amira Hegazy Dina Akmal Severity Index of Neonatal Septicemia in Neonatal Intensive Care units Using Score for Neonatal Acute Physiology-II Iranian Journal of Neonatology mortality neonates organ dysfunction sepsis snap-ii |
| title | Severity Index of Neonatal Septicemia in Neonatal Intensive Care units Using Score for Neonatal Acute Physiology-II |
| title_full | Severity Index of Neonatal Septicemia in Neonatal Intensive Care units Using Score for Neonatal Acute Physiology-II |
| title_fullStr | Severity Index of Neonatal Septicemia in Neonatal Intensive Care units Using Score for Neonatal Acute Physiology-II |
| title_full_unstemmed | Severity Index of Neonatal Septicemia in Neonatal Intensive Care units Using Score for Neonatal Acute Physiology-II |
| title_short | Severity Index of Neonatal Septicemia in Neonatal Intensive Care units Using Score for Neonatal Acute Physiology-II |
| title_sort | severity index of neonatal septicemia in neonatal intensive care units using score for neonatal acute physiology ii |
| topic | mortality neonates organ dysfunction sepsis snap-ii |
| url | https://ijn.mums.ac.ir/article_18481_93723c2ce7cda7d9f4299c0b44b69c21.pdf |
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