PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53
Abstract Colorectal cancer is the most common gastrointestinal cancer and causes severe damage to human health. PRDX2 is a member of the peroxiredoxin family reported to have a high level of expression in colorectal cancer. However, the mechanisms by which PRDX2 promotes the proliferation of colorec...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2021-06-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-021-03888-1 |
| _version_ | 1819088893480271872 |
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| author | Wuyi Wang Jinlai Wei Hairong Zhang Xiangru Zheng He Zhou Yajun Luo Jianguo Yang Qican Deng Siqi Huang Zhongxue Fu |
| author_facet | Wuyi Wang Jinlai Wei Hairong Zhang Xiangru Zheng He Zhou Yajun Luo Jianguo Yang Qican Deng Siqi Huang Zhongxue Fu |
| author_sort | Wuyi Wang |
| collection | DOAJ |
| description | Abstract Colorectal cancer is the most common gastrointestinal cancer and causes severe damage to human health. PRDX2 is a member of the peroxiredoxin family reported to have a high level of expression in colorectal cancer. However, the mechanisms by which PRDX2 promotes the proliferation of colorectal cancer are still unclear. Here, the results indicated that PRDX2 expression was upregulated in colorectal cancer and closely correlated with poor prognosis. Functionally, PRDX2 promoted the proliferation of colorectal cancer cells. Mechanistically, PRDX2 could bind RPL4, reducing the interaction between RPL4 and MDM2. These findings demonstrate that the oncogenic property of PRDX2 may be attributed to its regulation of the RPL4-MDM2-p53 pathway, leading to p53 ubiquitinated degradation. |
| first_indexed | 2024-12-21T21:59:16Z |
| format | Article |
| id | doaj.art-6d5497889a1043a69d221184b4b4602c |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-12-21T21:59:16Z |
| publishDate | 2021-06-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-6d5497889a1043a69d221184b4b4602c2022-12-21T18:48:53ZengNature Publishing GroupCell Death and Disease2041-48892021-06-0112611010.1038/s41419-021-03888-1PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53Wuyi Wang0Jinlai Wei1Hairong Zhang2Xiangru Zheng3He Zhou4Yajun Luo5Jianguo Yang6Qican Deng7Siqi Huang8Zhongxue Fu9Department of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityDepartment of Gastrointestinal Surgery, First Affiliated Hospital of Chongqing Medical UniversityAbstract Colorectal cancer is the most common gastrointestinal cancer and causes severe damage to human health. PRDX2 is a member of the peroxiredoxin family reported to have a high level of expression in colorectal cancer. However, the mechanisms by which PRDX2 promotes the proliferation of colorectal cancer are still unclear. Here, the results indicated that PRDX2 expression was upregulated in colorectal cancer and closely correlated with poor prognosis. Functionally, PRDX2 promoted the proliferation of colorectal cancer cells. Mechanistically, PRDX2 could bind RPL4, reducing the interaction between RPL4 and MDM2. These findings demonstrate that the oncogenic property of PRDX2 may be attributed to its regulation of the RPL4-MDM2-p53 pathway, leading to p53 ubiquitinated degradation.https://doi.org/10.1038/s41419-021-03888-1 |
| spellingShingle | Wuyi Wang Jinlai Wei Hairong Zhang Xiangru Zheng He Zhou Yajun Luo Jianguo Yang Qican Deng Siqi Huang Zhongxue Fu PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53 Cell Death and Disease |
| title | PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53 |
| title_full | PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53 |
| title_fullStr | PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53 |
| title_full_unstemmed | PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53 |
| title_short | PRDX2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53 |
| title_sort | prdx2 promotes the proliferation of colorectal cancer cells by increasing the ubiquitinated degradation of p53 |
| url | https://doi.org/10.1038/s41419-021-03888-1 |
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