MR1- and HLA-E-Dependent Antigen Presentation of <i>Mycobacterium tuberculosis</i>
MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from <i>Mycobacterium tuberculosis</i> to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents pepti...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-11-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/22/14412 |
| Summary: | MR1 and HLA-E are highly conserved nonclassical antigen-presenting molecules. They can present antigens derived from <i>Mycobacterium tuberculosis</i> to a distinct subset of MR1-restricted or HLA-restricted CD8+ T cells. MR1 presents small microbial metabolites, and HLA-E presents peptides and glycopeptides. In this review, we will discuss the current understanding of MR1 and HLA-E antigen presentation in the context of <i>Mycobacterium tuberculosis</i> infection. |
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| ISSN: | 1661-6596 1422-0067 |