Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects
Knee osteoarthritis is one of the leading causes of chronic disability worldwide and is a significant social and economic burden on healthcare systems; hence it has become essential to develop methods to identify patients at risk for developing knee osteoarthritis at an early stage. Standard morphol...
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-12-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/1/54 |
| _version_ | 1797626037791621120 |
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| author | Carlo A. Mallio Caterina Bernetti Francesco Agostini Massimiliano Mangone Marco Paoloni Gabriele Santilli Francesca Maria Martina Carlo C. Quattrocchi Bruno Beomonte Zobel Andrea Bernetti |
| author_facet | Carlo A. Mallio Caterina Bernetti Francesco Agostini Massimiliano Mangone Marco Paoloni Gabriele Santilli Francesca Maria Martina Carlo C. Quattrocchi Bruno Beomonte Zobel Andrea Bernetti |
| author_sort | Carlo A. Mallio |
| collection | DOAJ |
| description | Knee osteoarthritis is one of the leading causes of chronic disability worldwide and is a significant social and economic burden on healthcare systems; hence it has become essential to develop methods to identify patients at risk for developing knee osteoarthritis at an early stage. Standard morphological MRI sequences are focused mostly on alterations seen in advanced stages of osteoarthritis. However, they possess low sensitivity for early, subtle, and potentially reversible changes of the degenerative process. In this review, we have summarized the state of the art with regard to innovative quantitative MRI techniques that exploit objective and quantifiable biomarkers to identify subtle alterations that occur in early stages of osteoarthritis in knee cartilage before any morphological alteration occurs and to capture potential effects on the brain. These novel MRI imaging tools are believed to have great potential for improving the current standard of care, but further research is needed to address limitations before these compositional techniques can be robustly applied in research and clinical settings. |
| first_indexed | 2024-03-11T10:04:56Z |
| format | Article |
| id | doaj.art-6d5659b3cbf2404c977064cdeebc05eb |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T10:04:56Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-6d5659b3cbf2404c977064cdeebc05eb2023-11-16T15:08:13ZengMDPI AGDiagnostics2075-44182022-12-011315410.3390/diagnostics13010054Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain EffectsCarlo A. Mallio0Caterina Bernetti1Francesco Agostini2Massimiliano Mangone3Marco Paoloni4Gabriele Santilli5Francesca Maria Martina6Carlo C. Quattrocchi7Bruno Beomonte Zobel8Andrea Bernetti9Unit of Diagnostic Imaging and Interventional Radiology, Campus Bio-Medico University of Rome, 00128 Rome, ItalyUnit of Diagnostic Imaging and Interventional Radiology, Campus Bio-Medico University of Rome, 00128 Rome, ItalyDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Surgical and Medical Sciences and Translational Medicine, Sapienza University of Rome, 00185 Rome, ItalyUnit of Diagnostic Imaging and Interventional Radiology, Campus Bio-Medico University of Rome, 00128 Rome, ItalyUnit of Diagnostic Imaging and Interventional Radiology, Campus Bio-Medico University of Rome, 00128 Rome, ItalyUnit of Diagnostic Imaging and Interventional Radiology, Campus Bio-Medico University of Rome, 00128 Rome, ItalyDepartment of Anatomical and Histological Sciences, Legal Medicine and Orthopedics, Sapienza University of Rome, 00185 Rome, ItalyKnee osteoarthritis is one of the leading causes of chronic disability worldwide and is a significant social and economic burden on healthcare systems; hence it has become essential to develop methods to identify patients at risk for developing knee osteoarthritis at an early stage. Standard morphological MRI sequences are focused mostly on alterations seen in advanced stages of osteoarthritis. However, they possess low sensitivity for early, subtle, and potentially reversible changes of the degenerative process. In this review, we have summarized the state of the art with regard to innovative quantitative MRI techniques that exploit objective and quantifiable biomarkers to identify subtle alterations that occur in early stages of osteoarthritis in knee cartilage before any morphological alteration occurs and to capture potential effects on the brain. These novel MRI imaging tools are believed to have great potential for improving the current standard of care, but further research is needed to address limitations before these compositional techniques can be robustly applied in research and clinical settings.https://www.mdpi.com/2075-4418/13/1/54knee osteoarthritisquantitative imagingMRIT1ρ mappingT2-mappingDGEMRIC |
| spellingShingle | Carlo A. Mallio Caterina Bernetti Francesco Agostini Massimiliano Mangone Marco Paoloni Gabriele Santilli Francesca Maria Martina Carlo C. Quattrocchi Bruno Beomonte Zobel Andrea Bernetti Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects Diagnostics knee osteoarthritis quantitative imaging MRI T1ρ mapping T2-mapping DGEMRIC |
| title | Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects |
| title_full | Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects |
| title_fullStr | Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects |
| title_full_unstemmed | Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects |
| title_short | Advanced MR Imaging for Knee Osteoarthritis: A Review on Local and Brain Effects |
| title_sort | advanced mr imaging for knee osteoarthritis a review on local and brain effects |
| topic | knee osteoarthritis quantitative imaging MRI T1ρ mapping T2-mapping DGEMRIC |
| url | https://www.mdpi.com/2075-4418/13/1/54 |
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