Research progress on the role and mechanism of ADAMTS9 in atherosclerosis
Atherosclerosis is an inflammatory disease of arterial stenosis caused by the imbalance of lipid metabolism and atherosclerotic plaques clustered on the arterial wall. It is the main pathological process of vascular diseases， such as stroke and coronary heart disease， etc. Atherosclerotic diseases y...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of New Medicine
2023-08-01
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| Series: | Xin yixue |
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| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1693894479040-1620116284.pdf |
| _version_ | 1797692731612463104 |
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| author | Zeng Shiting, Huang Zhiyong, Chen Linfa, Yuan Yanquan, Li Qingyu |
| author_facet | Zeng Shiting, Huang Zhiyong, Chen Linfa, Yuan Yanquan, Li Qingyu |
| author_sort | Zeng Shiting, Huang Zhiyong, Chen Linfa, Yuan Yanquan, Li Qingyu |
| collection | DOAJ |
| description | Atherosclerosis is an inflammatory disease of arterial stenosis caused by the imbalance of lipid metabolism and atherosclerotic plaques clustered on the arterial wall. It is the main pathological process of vascular diseases， such as stroke and coronary heart disease， etc. Atherosclerotic diseases yield high disability and death rates. Recent relevant studies have reported that ADAMTS9 is closely correlated with vascular pathophysiological processes. ADAMTS9 can degrade and assemble extracellular matrix， enhance vascular smooth muscle cell proliferation and migration， provoke pro-inflammatory response， promote intimal thickening， accelerate plaque rupture， and exert anti-angiogenesis effect. In this article， the role and mechanism of ADAMTS9 in the incidence and development of atherosclerosis were mainly summarized. |
| first_indexed | 2024-03-12T02:32:50Z |
| format | Article |
| id | doaj.art-6d56fa26fc00412581c9c9257828192d |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-03-12T02:32:50Z |
| publishDate | 2023-08-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj.art-6d56fa26fc00412581c9c9257828192d2023-09-05T07:06:50ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022023-08-0154854554810.3969/j.issn.0253-9802.2023.08.003Research progress on the role and mechanism of ADAMTS9 in atherosclerosisZeng Shiting, Huang Zhiyong, Chen Linfa, Yuan Yanquan, Li Qingyu0△Guangdong Medical University, Zhanjiang 524000, ChinaAtherosclerosis is an inflammatory disease of arterial stenosis caused by the imbalance of lipid metabolism and atherosclerotic plaques clustered on the arterial wall. It is the main pathological process of vascular diseases， such as stroke and coronary heart disease， etc. Atherosclerotic diseases yield high disability and death rates. Recent relevant studies have reported that ADAMTS9 is closely correlated with vascular pathophysiological processes. ADAMTS9 can degrade and assemble extracellular matrix， enhance vascular smooth muscle cell proliferation and migration， provoke pro-inflammatory response， promote intimal thickening， accelerate plaque rupture， and exert anti-angiogenesis effect. In this article， the role and mechanism of ADAMTS9 in the incidence and development of atherosclerosis were mainly summarized.https://www.xinyixue.cn/fileup/0253-9802/PDF/1693894479040-1620116284.pdfatherosclerosis|adamts9|gene polymorphism |
| spellingShingle | Zeng Shiting, Huang Zhiyong, Chen Linfa, Yuan Yanquan, Li Qingyu Research progress on the role and mechanism of ADAMTS9 in atherosclerosis Xin yixue atherosclerosis|adamts9|gene polymorphism |
| title | Research progress on the role and mechanism of ADAMTS9 in atherosclerosis |
| title_full | Research progress on the role and mechanism of ADAMTS9 in atherosclerosis |
| title_fullStr | Research progress on the role and mechanism of ADAMTS9 in atherosclerosis |
| title_full_unstemmed | Research progress on the role and mechanism of ADAMTS9 in atherosclerosis |
| title_short | Research progress on the role and mechanism of ADAMTS9 in atherosclerosis |
| title_sort | research progress on the role and mechanism of adamts9 in atherosclerosis |
| topic | atherosclerosis|adamts9|gene polymorphism |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1693894479040-1620116284.pdf |
| work_keys_str_mv | AT zengshitinghuangzhiyongchenlinfayuanyanquanliqingyu researchprogressontheroleandmechanismofadamts9inatherosclerosis |