Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer
Background and purpose: Longitudinal Positron Emission Tomography (PET) with hypoxia-specific radiotracers allows monitoring the time evolution of regions of increased radioresistance and may become fundamental in determining the radiochemotherapy outcome in Head-and-Neck Squamous Cell Carcinoma (HN...
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
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| Series: | Physics and Imaging in Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405631621000117 |
| _version_ | 1818573847997186048 |
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| author | Marta Lazzeroni Ana Ureba Nicole Wiedenmann Nils H. Nicolay Michael Mix Benedikt Thomann Dimos Baltas Iuliana Toma-Dasu Anca L. Grosu |
| author_facet | Marta Lazzeroni Ana Ureba Nicole Wiedenmann Nils H. Nicolay Michael Mix Benedikt Thomann Dimos Baltas Iuliana Toma-Dasu Anca L. Grosu |
| author_sort | Marta Lazzeroni |
| collection | DOAJ |
| description | Background and purpose: Longitudinal Positron Emission Tomography (PET) with hypoxia-specific radiotracers allows monitoring the time evolution of regions of increased radioresistance and may become fundamental in determining the radiochemotherapy outcome in Head-and-Neck Squamous Cell Carcinoma (HNSCC). The aim of this study was to investigate the evolution of the hypoxic target volume on oxygen partial pressure maps (pO2-HTV) derived from 18FMISO-PET images acquired before and during radiochemotherapy and to uncover correlations between extent and severity of hypoxia and treatment outcome. Material and methods: 18FMISO-PET/CT images were acquired at three time points (before treatment start, in weeks two and five) for twenty-eight HNSCC patients treated with radiochemotherapy. The images were converted into pO2 maps and corresponding pO2-HTVs (pO2-HTV1, pO2-HTV2, pO2-HTV3) were contoured at 10 mmHg. Different parameters describing the pO2-HTV time evolution were considered, such as the percent and absolute difference between the pO2-HTVs (%HTVi,j and HTVi-HTVj with i,j = 1, 2, 3, respectively) and the slope of the linear regression curve fitting the pO2-HTVs in time. Correlations were sought between the pO2-HTV evolution parameters and loco-regional recurrence (LRR) using the Receiver Operating Characteristic method. Results: The Area Under the Curve values for %HTV1,2, HTV1-HTV2, HTV1-HTV3 and the slope of the pO2-HTV linear regression curve were 0.75 (p = 0.04), 0.73 (p = 0.02), 0.73 (p = 0.02) and 0.75 (p = 0.007), respectively. Other parameter combinations were not statistically significant. Conclusions: The pO2-HTV evolution during radiochemotherapy showed predictive value for LRR. The changes in the tumour hypoxia during the first two treatment weeks may be used for adaptive personalized treatment approaches. |
| first_indexed | 2024-12-15T00:18:23Z |
| format | Article |
| id | doaj.art-6d581ad3258443e1b059865bd8f925bf |
| institution | Directory Open Access Journal |
| issn | 2405-6316 |
| language | English |
| last_indexed | 2024-12-15T00:18:23Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Physics and Imaging in Radiation Oncology |
| spelling | doaj.art-6d581ad3258443e1b059865bd8f925bf2022-12-21T22:42:24ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162021-01-0117100105Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancerMarta Lazzeroni0Ana Ureba1Nicole Wiedenmann2Nils H. Nicolay3Michael Mix4Benedikt Thomann5Dimos Baltas6Iuliana Toma-Dasu7Anca L. Grosu8Department of Physics, Stockholm, Sweden; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, Sweden; Corresponding author at: Medical Radiation Physics, Dept. of Physics, Stockholm University, P09:02, Box 260, S-171 76 Stockholm, Sweden.Skandion Clinic, Uppsala, Sweden; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, SwedenDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, GermanyDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, GermanyDepartment of Nuclear Medicine, University Medical Center, Freiburg, GermanyDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, GermanyDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, GermanyDepartment of Physics, Stockholm, Sweden; Department of Oncology and Pathology, Karolinska Institutet, Stockholm, SwedenDepartment of Radiation Oncology, Medical Center, Medical Faculty Freiburg, German Cancer Consortium (DKTK) Partner Site Freiburg, Freiburg, GermanyBackground and purpose: Longitudinal Positron Emission Tomography (PET) with hypoxia-specific radiotracers allows monitoring the time evolution of regions of increased radioresistance and may become fundamental in determining the radiochemotherapy outcome in Head-and-Neck Squamous Cell Carcinoma (HNSCC). The aim of this study was to investigate the evolution of the hypoxic target volume on oxygen partial pressure maps (pO2-HTV) derived from 18FMISO-PET images acquired before and during radiochemotherapy and to uncover correlations between extent and severity of hypoxia and treatment outcome. Material and methods: 18FMISO-PET/CT images were acquired at three time points (before treatment start, in weeks two and five) for twenty-eight HNSCC patients treated with radiochemotherapy. The images were converted into pO2 maps and corresponding pO2-HTVs (pO2-HTV1, pO2-HTV2, pO2-HTV3) were contoured at 10 mmHg. Different parameters describing the pO2-HTV time evolution were considered, such as the percent and absolute difference between the pO2-HTVs (%HTVi,j and HTVi-HTVj with i,j = 1, 2, 3, respectively) and the slope of the linear regression curve fitting the pO2-HTVs in time. Correlations were sought between the pO2-HTV evolution parameters and loco-regional recurrence (LRR) using the Receiver Operating Characteristic method. Results: The Area Under the Curve values for %HTV1,2, HTV1-HTV2, HTV1-HTV3 and the slope of the pO2-HTV linear regression curve were 0.75 (p = 0.04), 0.73 (p = 0.02), 0.73 (p = 0.02) and 0.75 (p = 0.007), respectively. Other parameter combinations were not statistically significant. Conclusions: The pO2-HTV evolution during radiochemotherapy showed predictive value for LRR. The changes in the tumour hypoxia during the first two treatment weeks may be used for adaptive personalized treatment approaches.http://www.sciencedirect.com/science/article/pii/S2405631621000117HypoxiaFMISO PETpO2HNSCCRadiochemotherapy |
| spellingShingle | Marta Lazzeroni Ana Ureba Nicole Wiedenmann Nils H. Nicolay Michael Mix Benedikt Thomann Dimos Baltas Iuliana Toma-Dasu Anca L. Grosu Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer Physics and Imaging in Radiation Oncology Hypoxia FMISO PET pO2 HNSCC Radiochemotherapy |
| title | Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer |
| title_full | Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer |
| title_fullStr | Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer |
| title_full_unstemmed | Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer |
| title_short | Evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer |
| title_sort | evolution of the hypoxic compartment on sequential oxygen partial pressure maps during radiochemotherapy in advanced head and neck cancer |
| topic | Hypoxia FMISO PET pO2 HNSCC Radiochemotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405631621000117 |
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