A novel function of human Pumilio proteins in cytoplasmic sensing of viral infection.
RIG-I-like receptor (RLR) plays a pivotal role in the detection of invading pathogens to initiate type I interferon (IFN) gene transcription. Since aberrant IFN production is harmful, RLR signaling is strictly regulated. However, the regulatory mechanisms are not fully understood. By expression clon...
Main Authors: | Ryo Narita, Kiyohiro Takahasi, Etsu Murakami, Emi Hirano, Seiji P Yamamoto, Mitsutoshi Yoneyama, Hiroki Kato, Takashi Fujita |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2014-10-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC4207803?pdf=render |
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