Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma
Abstract Objective(s) Absolute lymphocyte count (ALC) has been shown to be a prognostic indicator in other solid tumors. Given this, we aimed to evaluate the prognostic value of ALC in oral cavity squamous cell carcinoma (OSCC). Methods Using our institutional tumor registry data, we identified pati...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-08-01
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| Series: | Laryngoscope Investigative Otolaryngology |
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| Online Access: | https://doi.org/10.1002/lio2.1094 |
| _version_ | 1797738257177378816 |
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| author | Rema Shah Christina Liu Hemali P. Shah Benjamin L. Judson |
| author_facet | Rema Shah Christina Liu Hemali P. Shah Benjamin L. Judson |
| author_sort | Rema Shah |
| collection | DOAJ |
| description | Abstract Objective(s) Absolute lymphocyte count (ALC) has been shown to be a prognostic indicator in other solid tumors. Given this, we aimed to evaluate the prognostic value of ALC in oral cavity squamous cell carcinoma (OSCC). Methods Using our institutional tumor registry data, we identified patients ≥18 years old who were diagnosed with OSCC between 2012 and 2018. Preoperative ALC values within 30 days of surgery were collected through retrospective chart review. American Joint Committee on Cancer, 7th‐edition best stage was used to categorize cancers as early stage (stages 1 and 2) or late‐stage (stages 3 and 4). Primary outcomes were likelihood of recurrence and survival rates after 3 years. Results Of the 412 patients identified, 262 patients had available ALC data and met inclusion criteria. Early stage cancer patients who had lymphopenia did not have any significant difference in their rate of death ([OR], 1.71, CI: 0.54–5.45, p = .36) or likelihood recurrence ([OR], 0.60, CI: 0.06–5.87, p = .66) after controlling for age, tobacco use, alcohol use, positive margins, and adjuvant therapy. Late‐stage cancer patients who had lymphopenia also showed no difference in their rate of death ([OR], 2.74, CI: 0.65–11.6, p = .17) or likelihood of recurrence ([OR], 0.38, CI: 0.04–3.36, p = .38). Conclusions and Relevance This study evaluates the prognostic value of ALC in oral cavity cancers. Our findings demonstrate that pretreatment ALC is not significantly associated with recurrence and survival outcomes patients with OSCC. Level of Evidence III Lay Summary Absolute lymphocyte count (ALC) has been associated with prognosis in several cancers. We found that preoperative ALC was not associated with likelihood of survival or recurrence in patients with early stage or late‐stage oral cavity cancer. |
| first_indexed | 2024-03-12T13:41:13Z |
| format | Article |
| id | doaj.art-6d58c8c8f7fe48f8ac09a1ffef2f85c1 |
| institution | Directory Open Access Journal |
| issn | 2378-8038 |
| language | English |
| last_indexed | 2024-03-12T13:41:13Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Laryngoscope Investigative Otolaryngology |
| spelling | doaj.art-6d58c8c8f7fe48f8ac09a1ffef2f85c12023-08-23T18:20:17ZengWileyLaryngoscope Investigative Otolaryngology2378-80382023-08-018487087510.1002/lio2.1094Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinomaRema Shah0Christina Liu1Hemali P. Shah2Benjamin L. Judson3Yale University School of Medicine New Haven Connecticut USAYale University School of Medicine New Haven Connecticut USAYale University School of Medicine New Haven Connecticut USADivision of Otolaryngology‐Head and Neck Surgery Yale University School of Medicine New Haven Connecticut USAAbstract Objective(s) Absolute lymphocyte count (ALC) has been shown to be a prognostic indicator in other solid tumors. Given this, we aimed to evaluate the prognostic value of ALC in oral cavity squamous cell carcinoma (OSCC). Methods Using our institutional tumor registry data, we identified patients ≥18 years old who were diagnosed with OSCC between 2012 and 2018. Preoperative ALC values within 30 days of surgery were collected through retrospective chart review. American Joint Committee on Cancer, 7th‐edition best stage was used to categorize cancers as early stage (stages 1 and 2) or late‐stage (stages 3 and 4). Primary outcomes were likelihood of recurrence and survival rates after 3 years. Results Of the 412 patients identified, 262 patients had available ALC data and met inclusion criteria. Early stage cancer patients who had lymphopenia did not have any significant difference in their rate of death ([OR], 1.71, CI: 0.54–5.45, p = .36) or likelihood recurrence ([OR], 0.60, CI: 0.06–5.87, p = .66) after controlling for age, tobacco use, alcohol use, positive margins, and adjuvant therapy. Late‐stage cancer patients who had lymphopenia also showed no difference in their rate of death ([OR], 2.74, CI: 0.65–11.6, p = .17) or likelihood of recurrence ([OR], 0.38, CI: 0.04–3.36, p = .38). Conclusions and Relevance This study evaluates the prognostic value of ALC in oral cavity cancers. Our findings demonstrate that pretreatment ALC is not significantly associated with recurrence and survival outcomes patients with OSCC. Level of Evidence III Lay Summary Absolute lymphocyte count (ALC) has been associated with prognosis in several cancers. We found that preoperative ALC was not associated with likelihood of survival or recurrence in patients with early stage or late‐stage oral cavity cancer.https://doi.org/10.1002/lio2.1094lymphocyteoral cavityprognosissquamous cell carcinomasurvival |
| spellingShingle | Rema Shah Christina Liu Hemali P. Shah Benjamin L. Judson Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma Laryngoscope Investigative Otolaryngology lymphocyte oral cavity prognosis squamous cell carcinoma survival |
| title | Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma |
| title_full | Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma |
| title_fullStr | Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma |
| title_full_unstemmed | Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma |
| title_short | Prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma |
| title_sort | prognostic value of absolute lymphocyte count in oral cavity squamous cell carcinoma |
| topic | lymphocyte oral cavity prognosis squamous cell carcinoma survival |
| url | https://doi.org/10.1002/lio2.1094 |
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