Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose
Objective: We examined the association between non-alcoholic fatty liver disease (NAFLD) markers and fasting serum immunoreactive insulin (FIRI) and urinary albumin excretion (UAE). Subjects and methods: This study comprised Periods I and II from January 2007 to May 2009, and from June 2009 to Decem...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/10/3161 |
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| author | Shuichi Katoh Markku Peltonen Mikio Zeniya Yoichi Sakamoto Kazunori Utsunomiya Rimei Nishimura Jaakko Tuomilehto |
| author_facet | Shuichi Katoh Markku Peltonen Mikio Zeniya Yoichi Sakamoto Kazunori Utsunomiya Rimei Nishimura Jaakko Tuomilehto |
| author_sort | Shuichi Katoh |
| collection | DOAJ |
| description | Objective: We examined the association between non-alcoholic fatty liver disease (NAFLD) markers and fasting serum immunoreactive insulin (FIRI) and urinary albumin excretion (UAE). Subjects and methods: This study comprised Periods I and II from January 2007 to May 2009, and from June 2009 to December 2011, respectively. After excluding people with ethanol intake ≥210 g/week in men and ≥140 g/week in women, 961 people (613 men, 348 women; mean age: 44 years) were included. We evaluated the fatty liver using ultrasonography score (FLUS) and measured liver enzymes. Results: The mean observation period was 25 ± 9 months. We stratified people into two groups by fasting plasma glucose (FPG) in Period I. The cutoff point between the lower FPG and higher FPG was 100 mg/dL. In regression analysis, serum alanine aminotransferase (ALT) (<i>p</i> < 0.001), FLUS (<i>p</i> < 0.001) and γ-glutamyl transpeptidase (GGTP) (<i>p</i> = 0.022) in Period I were independently associated with FIRI in Period II, whereas in all participants FPG was not. ALT (<i>p</i> < 0.001) and GGTP (<i>p</i> = 0.001) were also independently associated with UAE in people with FPG < 100 mg/dL in Period II. Conclusions: Some NAFLD markers were associated with FIRI and UAE independently of fasting plasma glucose. |
| first_indexed | 2024-03-10T15:56:50Z |
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| id | doaj.art-6d58fff14796482a8ad6e6c07eb78911 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T15:56:50Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6d58fff14796482a8ad6e6c07eb789112023-11-20T15:33:32ZengMDPI AGJournal of Clinical Medicine2077-03832020-09-01910316110.3390/jcm9103161Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma GlucoseShuichi Katoh0Markku Peltonen1Mikio Zeniya2Yoichi Sakamoto3Kazunori Utsunomiya4Rimei Nishimura5Jaakko Tuomilehto6Division of Diabetes, Metabolism & Endocrinology, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, JapanPublic Health Promotion Unit, Finnish Institute for Health and Welfare, Mannerheimintie 166, FI-00271 Helsinki, FinlandGastroenterology, Akasaka Sanno Medical Center, 4-1-26W Akasaka, Minato-ku, Tokyo 107-8402, JapanThe Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, JapanDepartment of Health-Care Center, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Diabetes, Metabolism & Endocrinology, The Jikei University School of Medicine, 3-25-8 Nishishimbashi, Minato-ku, Tokyo 105-8461, JapanPublic Health Promotion Unit, Finnish Institute for Health and Welfare, Mannerheimintie 166, FI-00271 Helsinki, FinlandObjective: We examined the association between non-alcoholic fatty liver disease (NAFLD) markers and fasting serum immunoreactive insulin (FIRI) and urinary albumin excretion (UAE). Subjects and methods: This study comprised Periods I and II from January 2007 to May 2009, and from June 2009 to December 2011, respectively. After excluding people with ethanol intake ≥210 g/week in men and ≥140 g/week in women, 961 people (613 men, 348 women; mean age: 44 years) were included. We evaluated the fatty liver using ultrasonography score (FLUS) and measured liver enzymes. Results: The mean observation period was 25 ± 9 months. We stratified people into two groups by fasting plasma glucose (FPG) in Period I. The cutoff point between the lower FPG and higher FPG was 100 mg/dL. In regression analysis, serum alanine aminotransferase (ALT) (<i>p</i> < 0.001), FLUS (<i>p</i> < 0.001) and γ-glutamyl transpeptidase (GGTP) (<i>p</i> = 0.022) in Period I were independently associated with FIRI in Period II, whereas in all participants FPG was not. ALT (<i>p</i> < 0.001) and GGTP (<i>p</i> = 0.001) were also independently associated with UAE in people with FPG < 100 mg/dL in Period II. Conclusions: Some NAFLD markers were associated with FIRI and UAE independently of fasting plasma glucose.https://www.mdpi.com/2077-0383/9/10/3161non-alcoholic fatty liver diseasefasting serum insulinurinary albumin excretionserum alanine aminotransferasediabetesimpaired fasting glucose |
| spellingShingle | Shuichi Katoh Markku Peltonen Mikio Zeniya Yoichi Sakamoto Kazunori Utsunomiya Rimei Nishimura Jaakko Tuomilehto Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose Journal of Clinical Medicine non-alcoholic fatty liver disease fasting serum insulin urinary albumin excretion serum alanine aminotransferase diabetes impaired fasting glucose |
| title | Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose |
| title_full | Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose |
| title_fullStr | Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose |
| title_full_unstemmed | Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose |
| title_short | Non-Alcoholic Fatty Liver Disease Markers Associated with Fasting Serum Insulin and Urinary Albumin Excretion Independent of Fasting Plasma Glucose |
| title_sort | non alcoholic fatty liver disease markers associated with fasting serum insulin and urinary albumin excretion independent of fasting plasma glucose |
| topic | non-alcoholic fatty liver disease fasting serum insulin urinary albumin excretion serum alanine aminotransferase diabetes impaired fasting glucose |
| url | https://www.mdpi.com/2077-0383/9/10/3161 |
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