Clinical relevance of Paliperidone Palmitate three-month intramuscular injection formulation: an Italian Real-World, Retrospective, one-year Mirror Image Study
Introduction Paliperidone Palmitate 3-month (PP3M) formulation, introduced in Italy since 2017, is an effective and safety therapeutic option for patients with schizophrenia, clinically stable with 1-month formulation (PP1M). Only a few “Real World” studies investigated the clinical relevance of PP...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-06-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933822008793/type/journal_article |
| _version_ | 1797616508212346880 |
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| author | S. Vanzetto G. Cirnigliaro V. Battini E. Piccoli M. Vismara C. Viganò B. Dell’Osso |
| author_facet | S. Vanzetto G. Cirnigliaro V. Battini E. Piccoli M. Vismara C. Viganò B. Dell’Osso |
| author_sort | S. Vanzetto |
| collection | DOAJ |
| description |
Introduction
Paliperidone Palmitate 3-month (PP3M) formulation, introduced in Italy since 2017, is an effective and safety therapeutic option for patients with schizophrenia, clinically stable with 1-month formulation (PP1M). Only a few “Real World” studies investigated the clinical relevance of PP3M and the long-term clinical and health resource utilization outcomes.
Objectives
The aim of this retrospective, mirror image study was to evaluate the efficacy of PP3M in terms of continuity of care and number of hospitalizations.
Methods
Fifty outpatients treated with Paliperidone Palmitate (PP) were recruited from a Community Mental Health Centre (CMHC) in Milan. Statistical analysis were conducted with SPSS 26. Frequencies of hospitalization 6 months before and after the start of PP3M were compared using the McNemar test, setting the significance to p<0.05.
Results
This study involved 34 patients (68%) treated with PP1M and 16 (32%) treated with PP3M.The median time interval between PP1M and PP3M was 14 months. After the switch to PP3M, 69% of patients continued to visit the CMHC with an unchanged frequency (50% once/month, 6% more than once/month), while 31% with a decreased frequency (once/3 months). No patient increased the frequency of CMHC visits or started visiting it discontinuously. 44% of subjects had had at least one hospitalization prior to the switch and no hospitalizations after (p=0.016). Moreover, no patients showed increased hospitalizations
Conclusions
In this study PP3M clinical relevance was confirmed comparing pre-initiation and post-initiation 6-months time intervals: hospitalizations number significantly decreased, while the continuity of care was preserved. Further studies on a greater sample are necessary to support these preliminary data.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:42:11Z |
| format | Article |
| id | doaj.art-6d5b71f68b8349209d734c694a5ea9f1 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:42:11Z |
| publishDate | 2022-06-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-6d5b71f68b8349209d734c694a5ea9f12023-11-17T05:08:23ZengCambridge University PressEuropean Psychiatry0924-93381778-35852022-06-0165S346S34610.1192/j.eurpsy.2022.879Clinical relevance of Paliperidone Palmitate three-month intramuscular injection formulation: an Italian Real-World, Retrospective, one-year Mirror Image StudyS. Vanzetto0G. Cirnigliaro1V. Battini2E. Piccoli3M. Vismara4C. Viganò5B. Dell’Osso6Luigi Sacco University Hospital, Psychiatry 2 Unit, ASST FBF-Sacco, University Of Milan, Milan, ItalyLuigi Sacco University Hospital, Psychiatry 2 Unit, ASST FBF-Sacco, University Of Milan, Milan, ItalyDepartment of Clinical Pharmacology, ASST Fatebenefratelli-Sacco, University Of Milan, Milan, ItalyLuigi Sacco University Hospital, Psychiatry 2 Unit, ASST FBF-Sacco, University Of Milan, Milan, ItalyLuigi Sacco University Hospital, Psychiatry 2 Unit, ASST FBF-Sacco, University Of Milan, Milan, Italy “Aldo Ravelli” Center for Nanotechnology and Neurostimulation”, University Of Milan, Milan, ItalyLuigi Sacco University Hospital, Psychiatry 2 Unit, ASST FBF-Sacco, University Of Milan, Milan, ItalyLuigi Sacco University Hospital, Psychiatry 2 Unit, ASST FBF-Sacco, University Of Milan, Milan, Italy “Aldo Ravelli” Center for Nanotechnology and Neurostimulation”, University Of Milan, Milan, Italy Department of Psychiatry and Behavioral Sciences, Stanford University, Milan, Italy “Centro per lo studio dei meccanismi molecolari alla base delle patologie neuro-psico-geriatriche”, University Of Milan, Milan, Italy Introduction Paliperidone Palmitate 3-month (PP3M) formulation, introduced in Italy since 2017, is an effective and safety therapeutic option for patients with schizophrenia, clinically stable with 1-month formulation (PP1M). Only a few “Real World” studies investigated the clinical relevance of PP3M and the long-term clinical and health resource utilization outcomes. Objectives The aim of this retrospective, mirror image study was to evaluate the efficacy of PP3M in terms of continuity of care and number of hospitalizations. Methods Fifty outpatients treated with Paliperidone Palmitate (PP) were recruited from a Community Mental Health Centre (CMHC) in Milan. Statistical analysis were conducted with SPSS 26. Frequencies of hospitalization 6 months before and after the start of PP3M were compared using the McNemar test, setting the significance to p<0.05. Results This study involved 34 patients (68%) treated with PP1M and 16 (32%) treated with PP3M.The median time interval between PP1M and PP3M was 14 months. After the switch to PP3M, 69% of patients continued to visit the CMHC with an unchanged frequency (50% once/month, 6% more than once/month), while 31% with a decreased frequency (once/3 months). No patient increased the frequency of CMHC visits or started visiting it discontinuously. 44% of subjects had had at least one hospitalization prior to the switch and no hospitalizations after (p=0.016). Moreover, no patients showed increased hospitalizations Conclusions In this study PP3M clinical relevance was confirmed comparing pre-initiation and post-initiation 6-months time intervals: hospitalizations number significantly decreased, while the continuity of care was preserved. Further studies on a greater sample are necessary to support these preliminary data. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933822008793/type/journal_articleone-year Mirror Image Studyclinical relevancepsychopharmacologyPaliperidone Palmitate 3-month formulation |
| spellingShingle | S. Vanzetto G. Cirnigliaro V. Battini E. Piccoli M. Vismara C. Viganò B. Dell’Osso Clinical relevance of Paliperidone Palmitate three-month intramuscular injection formulation: an Italian Real-World, Retrospective, one-year Mirror Image Study European Psychiatry one-year Mirror Image Study clinical relevance psychopharmacology Paliperidone Palmitate 3-month formulation |
| title | Clinical relevance of Paliperidone Palmitate three-month intramuscular injection formulation: an Italian Real-World, Retrospective, one-year Mirror Image Study |
| title_full | Clinical relevance of Paliperidone Palmitate three-month intramuscular injection formulation: an Italian Real-World, Retrospective, one-year Mirror Image Study |
| title_fullStr | Clinical relevance of Paliperidone Palmitate three-month intramuscular injection formulation: an Italian Real-World, Retrospective, one-year Mirror Image Study |
| title_full_unstemmed | Clinical relevance of Paliperidone Palmitate three-month intramuscular injection formulation: an Italian Real-World, Retrospective, one-year Mirror Image Study |
| title_short | Clinical relevance of Paliperidone Palmitate three-month intramuscular injection formulation: an Italian Real-World, Retrospective, one-year Mirror Image Study |
| title_sort | clinical relevance of paliperidone palmitate three month intramuscular injection formulation an italian real world retrospective one year mirror image study |
| topic | one-year Mirror Image Study clinical relevance psychopharmacology Paliperidone Palmitate 3-month formulation |
| url | https://www.cambridge.org/core/product/identifier/S0924933822008793/type/journal_article |
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