Does vitamin D serum level affect prognosis of COVID-19 patients?
Background: Since the beginning of the Coronavirus disease 2019 (COVID-19) pandemic there have been contradictions and speculations about the relationship between vitamin D and COVID-19. Given that there is an association between vitamin D deficiency and some diseases – including cancer, autoimmune...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-06-01
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| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971221003957 |
| _version_ | 1818600989657137152 |
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| author | Maryam Nasiri Javad Khodadadi Sedigheh Molaei |
| author_facet | Maryam Nasiri Javad Khodadadi Sedigheh Molaei |
| author_sort | Maryam Nasiri |
| collection | DOAJ |
| description | Background: Since the beginning of the Coronavirus disease 2019 (COVID-19) pandemic there have been contradictions and speculations about the relationship between vitamin D and COVID-19. Given that there is an association between vitamin D deficiency and some diseases – including cancer, autoimmune disease and some infectious diseases – a higher incidence and mortality rate in the vitamin-D-deficient COVID-19 population was not a surprise; conversely, some research would argue this relationship. Considering these contradictions, this study aimed to determine the relationship between prognosis and vitamin D level in cases with COVID-19. Methods: In this cross-sectional study, 329 confirmed cases of COVID-19 – who were admitted to Kamkar-ArabNia Hospital in Qom city, Iran from March–July 2020 – were categorized into three groups according to vitamin D serum levels (ng/ml): sufficient (>30), insufficient (20–30) and deficient (<20). Prognosis was determined across the groups. Results: There was a significant difference in hospital stay between patients with sufficient and insufficient vitamin D levels (P = 0.007). Adjusting vitamin D levels for confounding variables, linear regression underscored significant differences in the association between length of hospitalization and lower vitamin D levels, with a longer stay noted in insufficient groups (P = 0.002). However, there was no significant difference in the time interval to return to normal oxygen level (from SpO2 < 93%) or death rate between groups (P > 0.05). Conclusion: There was a significant association between hospital stay and lower serum vitamin D levels. However, the relationship between vitamin D status and death rate or the time interval to return to normal oxygen levels was not significant. |
| first_indexed | 2024-12-16T12:44:15Z |
| format | Article |
| id | doaj.art-6d5c99630581484eab32f43de59e27c9 |
| institution | Directory Open Access Journal |
| issn | 1201-9712 |
| language | English |
| last_indexed | 2024-12-16T12:44:15Z |
| publishDate | 2021-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj.art-6d5c99630581484eab32f43de59e27c92022-12-21T22:31:19ZengElsevierInternational Journal of Infectious Diseases1201-97122021-06-01107264267Does vitamin D serum level affect prognosis of COVID-19 patients?Maryam Nasiri0Javad Khodadadi1Sedigheh Molaei2Department of Infectious Diseases, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran; Corresponding author at: Department of Infectious Diseases, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.Department of Infectious Diseases, Faculty of Medicine, Qom University of Medical Sciences, Qom, IranStudent Research Committee, School of Medicine, Qom University of Medical Sciences, Qom, IranBackground: Since the beginning of the Coronavirus disease 2019 (COVID-19) pandemic there have been contradictions and speculations about the relationship between vitamin D and COVID-19. Given that there is an association between vitamin D deficiency and some diseases – including cancer, autoimmune disease and some infectious diseases – a higher incidence and mortality rate in the vitamin-D-deficient COVID-19 population was not a surprise; conversely, some research would argue this relationship. Considering these contradictions, this study aimed to determine the relationship between prognosis and vitamin D level in cases with COVID-19. Methods: In this cross-sectional study, 329 confirmed cases of COVID-19 – who were admitted to Kamkar-ArabNia Hospital in Qom city, Iran from March–July 2020 – were categorized into three groups according to vitamin D serum levels (ng/ml): sufficient (>30), insufficient (20–30) and deficient (<20). Prognosis was determined across the groups. Results: There was a significant difference in hospital stay between patients with sufficient and insufficient vitamin D levels (P = 0.007). Adjusting vitamin D levels for confounding variables, linear regression underscored significant differences in the association between length of hospitalization and lower vitamin D levels, with a longer stay noted in insufficient groups (P = 0.002). However, there was no significant difference in the time interval to return to normal oxygen level (from SpO2 < 93%) or death rate between groups (P > 0.05). Conclusion: There was a significant association between hospital stay and lower serum vitamin D levels. However, the relationship between vitamin D status and death rate or the time interval to return to normal oxygen levels was not significant.http://www.sciencedirect.com/science/article/pii/S1201971221003957COVID-19Vitamin DPrognosis |
| spellingShingle | Maryam Nasiri Javad Khodadadi Sedigheh Molaei Does vitamin D serum level affect prognosis of COVID-19 patients? International Journal of Infectious Diseases COVID-19 Vitamin D Prognosis |
| title | Does vitamin D serum level affect prognosis of COVID-19 patients? |
| title_full | Does vitamin D serum level affect prognosis of COVID-19 patients? |
| title_fullStr | Does vitamin D serum level affect prognosis of COVID-19 patients? |
| title_full_unstemmed | Does vitamin D serum level affect prognosis of COVID-19 patients? |
| title_short | Does vitamin D serum level affect prognosis of COVID-19 patients? |
| title_sort | does vitamin d serum level affect prognosis of covid 19 patients |
| topic | COVID-19 Vitamin D Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S1201971221003957 |
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