S100A4/TCF Complex Transcription Regulation Drives Epithelial-Mesenchymal Transition in Chronic Sinusitis Through Wnt/GSK-3β/β-Catenin Signaling

S100A4/TCF Complex Transcription Regulation Drives Epithelial-Mesenchymal Transition in Chronic Sinusitis Through Wnt/GSK-3β/β-Catenin Signaling

Epithelial-mesenchymal transition (EMT) is thought to be involved in the tissue remodeling and long-term inflammatory process of chronic sinusitis (CRS), but the driving mechanism is still unclear. Using high-resolution mass spectrometry, we performed a proteomic screen of CRS nasal mucosal tissue t...

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Bibliographic Details
Main Authors: Ningyue Gong, Lei Shi, Xin Bing, Hui Li, Houyang Hu, Pan Zhang, Huiming Yang, Na Guo, Hongjie Du, Ming Xia, Chengcheng Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
CRS
epigenetic regulation
EMT
S100A4
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.835888/full

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