The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism

The insulin-degrading enzyme as a link between insulin and neuropeptides metabolism

We have applied a recently developed HPLC-MS enzymatic assay to investigate the cryptic peptides generated by the action of the insulin-degrading enzyme (IDE) on some neuropeptides (NPs) involved in the development of tolerance and dependence to opioids. Particularly, the tested NPs are generated fr...

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Bibliographic Details
Main Authors: Dorota Wacławczyk, Jerzy Silberring, Giuseppe Grasso
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
insulin-degrading enzyme
neuropeptides
diabetes
opiods
Online Access:http://dx.doi.org/10.1080/14756366.2020.1850712

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