Alcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrest
Abstract The risk of having atrial fibrillation (AF) is associated with alcohol intake. However, it is not clear whether sudden cardiac arrest (SCA) and ventricular arrhythmia (VA) including ventricular tachycardia, flutter, or fibrillation have similar associations with alcohol. We aimed to evaluat...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-55434-6 |
| _version_ | 1797274868401569792 |
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| author | Yun Gi Kim Dong Yun Kim Seung-Young Roh Joo Hee Jeong Hyoung Seok Lee Kyongjin Min Yun Young Choi Kyung-Do Han Jaemin Shim Jong-Il Choi Young-Hoon Kim |
| author_facet | Yun Gi Kim Dong Yun Kim Seung-Young Roh Joo Hee Jeong Hyoung Seok Lee Kyongjin Min Yun Young Choi Kyung-Do Han Jaemin Shim Jong-Il Choi Young-Hoon Kim |
| author_sort | Yun Gi Kim |
| collection | DOAJ |
| description | Abstract The risk of having atrial fibrillation (AF) is associated with alcohol intake. However, it is not clear whether sudden cardiac arrest (SCA) and ventricular arrhythmia (VA) including ventricular tachycardia, flutter, or fibrillation have similar associations with alcohol. We aimed to evaluate the association of alcohol intake with all-cause death, new-onset AF, VA, and SCA using single cohort with a sufficient sample size. A total of 3,990,373 people without a prior history of AF, VAs, or SCA was enrolled in this study based on nationwide health check-up in 2009. We classified the participants into four groups according to weekly alcohol consumption, and evaluated the association of alcohol consumption with each outcome. We observed a significant association between mild (hazard ratio [HR] = 0.826; 95% confidence interval [CI] = 0.815–0.838) to moderate (HR = 0.930; 95% CI = 0.912–0.947) drinking with decreased risk of all-cause mortality. However heavy drinking (HR = 1.108; 95% CI = 1.087–1.129) was associated with increased all-cause death. The risk of new-onset AF was significantly associated with moderate (HR = 1.129; 95% CI = 1.097–1.161) and heavy (HR = 1.298; 95% CI = 1.261–1.337) drinking. However, the risk of SCA showed negative association with all degrees of alcohol intake: 20% (HR = 0.803; 95% CI = 0.769–0.839), 15% (HR = 0.853; 95% CI = 0.806–0.902), and 8% (HR = 0.918; 95% CI = 0.866–0.974) lower risk for mild, moderate, and heavy drinkers, respectively. Mild drinking was associated with reduced risk of VA with moderate and heavy drinking having no associations. In conclusion, the association between alcohol and various outcomes in this study were heterogeneous. Alcohol might have different influences on various cardiac disorders. |
| first_indexed | 2024-03-07T15:04:18Z |
| format | Article |
| id | doaj.art-6d5f7601db0c498ebdb916aeb2ac1ad0 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-07T15:04:18Z |
| publishDate | 2024-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-6d5f7601db0c498ebdb916aeb2ac1ad02024-03-05T18:58:11ZengNature PortfolioScientific Reports2045-23222024-02-0114111010.1038/s41598-024-55434-6Alcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrestYun Gi Kim0Dong Yun Kim1Seung-Young Roh2Joo Hee Jeong3Hyoung Seok Lee4Kyongjin Min5Yun Young Choi6Kyung-Do Han7Jaemin Shim8Jong-Il Choi9Young-Hoon Kim10Division of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalKorea University College of MedicineDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Guro HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDepartment of Statistics and Actuarial Science, Soongsil UniversityDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalDivision of Cardiology, Department of Internal Medicine, Korea University College of Medicine and Korea University Anam HospitalAbstract The risk of having atrial fibrillation (AF) is associated with alcohol intake. However, it is not clear whether sudden cardiac arrest (SCA) and ventricular arrhythmia (VA) including ventricular tachycardia, flutter, or fibrillation have similar associations with alcohol. We aimed to evaluate the association of alcohol intake with all-cause death, new-onset AF, VA, and SCA using single cohort with a sufficient sample size. A total of 3,990,373 people without a prior history of AF, VAs, or SCA was enrolled in this study based on nationwide health check-up in 2009. We classified the participants into four groups according to weekly alcohol consumption, and evaluated the association of alcohol consumption with each outcome. We observed a significant association between mild (hazard ratio [HR] = 0.826; 95% confidence interval [CI] = 0.815–0.838) to moderate (HR = 0.930; 95% CI = 0.912–0.947) drinking with decreased risk of all-cause mortality. However heavy drinking (HR = 1.108; 95% CI = 1.087–1.129) was associated with increased all-cause death. The risk of new-onset AF was significantly associated with moderate (HR = 1.129; 95% CI = 1.097–1.161) and heavy (HR = 1.298; 95% CI = 1.261–1.337) drinking. However, the risk of SCA showed negative association with all degrees of alcohol intake: 20% (HR = 0.803; 95% CI = 0.769–0.839), 15% (HR = 0.853; 95% CI = 0.806–0.902), and 8% (HR = 0.918; 95% CI = 0.866–0.974) lower risk for mild, moderate, and heavy drinkers, respectively. Mild drinking was associated with reduced risk of VA with moderate and heavy drinking having no associations. In conclusion, the association between alcohol and various outcomes in this study were heterogeneous. Alcohol might have different influences on various cardiac disorders.https://doi.org/10.1038/s41598-024-55434-6Sudden cardiac arrestAtrial fibrillationVentricular arrhythmiaAlcohol |
| spellingShingle | Yun Gi Kim Dong Yun Kim Seung-Young Roh Joo Hee Jeong Hyoung Seok Lee Kyongjin Min Yun Young Choi Kyung-Do Han Jaemin Shim Jong-Il Choi Young-Hoon Kim Alcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrest Scientific Reports Sudden cardiac arrest Atrial fibrillation Ventricular arrhythmia Alcohol |
| title | Alcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrest |
| title_full | Alcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrest |
| title_fullStr | Alcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrest |
| title_full_unstemmed | Alcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrest |
| title_short | Alcohol and the risk of all-cause death, atrial fibrillation, ventricular arrhythmia, and sudden cardiac arrest |
| title_sort | alcohol and the risk of all cause death atrial fibrillation ventricular arrhythmia and sudden cardiac arrest |
| topic | Sudden cardiac arrest Atrial fibrillation Ventricular arrhythmia Alcohol |
| url | https://doi.org/10.1038/s41598-024-55434-6 |
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