Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns: a prospective birth cohort in Taiwan.
The purpose of this study was to examine the relationship of phthalates exposure with thyroid function in pregnant women and their newborns.One hundred and forty-eight Taiwanese maternal and infant pairs were recruited from E-Da hospital in southern Taiwan between 2009 and 2010 for analysis. One-spo...
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| Format: | Article |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4456348?pdf=render |
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| author | Fu-Chen Kuo Sheng-Wen Su Chia-Fang Wu Meng-Chuan Huang Jentaie Shiea Bai-Hsiu Chen Yi-Ling Chen Ming-Tsang Wu |
| author_facet | Fu-Chen Kuo Sheng-Wen Su Chia-Fang Wu Meng-Chuan Huang Jentaie Shiea Bai-Hsiu Chen Yi-Ling Chen Ming-Tsang Wu |
| author_sort | Fu-Chen Kuo |
| collection | DOAJ |
| description | The purpose of this study was to examine the relationship of phthalates exposure with thyroid function in pregnant women and their newborns.One hundred and forty-eight Taiwanese maternal and infant pairs were recruited from E-Da hospital in southern Taiwan between 2009 and 2010 for analysis. One-spot urine samples and blood samples in the third trimester of pregnant women and their cord blood samples at delivery were collected. Nine phthalate metabolites in urine were determined by triple quadrupole liquid chromatography tandem mass spectrometry, whereas serum from pregnant women and their cord blood were used to measure thyroid profiles (thyroid-stimulating hormone [TSH], thyroxine, free thyroxine, and triiodothyronine) by radioimmunoassay.Median levels of urinary mono-n-butyl phthalate, mono-ethyl phthalate, and mono-(2-ethyl-5-oxohexyl) phthalate (μg/g creatinine) were the three highest phthalate metabolites, which were 37.81, 34.51, and 21.73, respectively. Using Bonferroni correction at a significance of < 0.006, we found that urinary mono-benzyl phthalate (MBzP) levels were significantly and negatively associated with serum TSH in cord blood (β = -2.644, p = 0.003).Maternal urinary MBzP, of which the parental compound is butylbenzyl phthalate, may affect TSH activity in newborns. The alteration of thyroid homeostasis by certain phthalates in the early life, a critical period for neurodevelopment, is an urgent concern. |
| first_indexed | 2024-12-19T22:54:54Z |
| format | Article |
| id | doaj.art-6d5fee4656ef402986657342e4cdc74b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T22:54:54Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-6d5fee4656ef402986657342e4cdc74b2022-12-21T20:02:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01106e012388410.1371/journal.pone.0123884Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns: a prospective birth cohort in Taiwan.Fu-Chen KuoSheng-Wen SuChia-Fang WuMeng-Chuan HuangJentaie ShieaBai-Hsiu ChenYi-Ling ChenMing-Tsang WuThe purpose of this study was to examine the relationship of phthalates exposure with thyroid function in pregnant women and their newborns.One hundred and forty-eight Taiwanese maternal and infant pairs were recruited from E-Da hospital in southern Taiwan between 2009 and 2010 for analysis. One-spot urine samples and blood samples in the third trimester of pregnant women and their cord blood samples at delivery were collected. Nine phthalate metabolites in urine were determined by triple quadrupole liquid chromatography tandem mass spectrometry, whereas serum from pregnant women and their cord blood were used to measure thyroid profiles (thyroid-stimulating hormone [TSH], thyroxine, free thyroxine, and triiodothyronine) by radioimmunoassay.Median levels of urinary mono-n-butyl phthalate, mono-ethyl phthalate, and mono-(2-ethyl-5-oxohexyl) phthalate (μg/g creatinine) were the three highest phthalate metabolites, which were 37.81, 34.51, and 21.73, respectively. Using Bonferroni correction at a significance of < 0.006, we found that urinary mono-benzyl phthalate (MBzP) levels were significantly and negatively associated with serum TSH in cord blood (β = -2.644, p = 0.003).Maternal urinary MBzP, of which the parental compound is butylbenzyl phthalate, may affect TSH activity in newborns. The alteration of thyroid homeostasis by certain phthalates in the early life, a critical period for neurodevelopment, is an urgent concern.http://europepmc.org/articles/PMC4456348?pdf=render |
| spellingShingle | Fu-Chen Kuo Sheng-Wen Su Chia-Fang Wu Meng-Chuan Huang Jentaie Shiea Bai-Hsiu Chen Yi-Ling Chen Ming-Tsang Wu Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns: a prospective birth cohort in Taiwan. PLoS ONE |
| title | Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns: a prospective birth cohort in Taiwan. |
| title_full | Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns: a prospective birth cohort in Taiwan. |
| title_fullStr | Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns: a prospective birth cohort in Taiwan. |
| title_full_unstemmed | Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns: a prospective birth cohort in Taiwan. |
| title_short | Relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns: a prospective birth cohort in Taiwan. |
| title_sort | relationship of urinary phthalate metabolites with serum thyroid hormones in pregnant women and their newborns a prospective birth cohort in taiwan |
| url | http://europepmc.org/articles/PMC4456348?pdf=render |
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