Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies
The SWI/SNF complex is an important multi-subunit protein complex that regulates gene expression in eukaryotic cells. It is widely involved in various biological processes such as signal transduction, cell cycle and cell differentiation. SWI/SNF complex subunit mutations occur in more than 20% of ma...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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Magazine House of Cancer Research on Prevention and Treatment
2019-07-01
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| Series: | Zhongliu Fangzhi Yanjiu |
| Subjects: | |
| Online Access: | http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.1871.htm |
| _version_ | 1811268720497000448 |
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| author | GUO Qing RAO Qiu ZHOU Zhiyi |
| author_facet | GUO Qing RAO Qiu ZHOU Zhiyi |
| author_sort | GUO Qing |
| collection | DOAJ |
| description | The SWI/SNF complex is an important multi-subunit protein complex that regulates gene expression in eukaryotic cells. It is widely involved in various biological processes such as signal transduction, cell cycle and cell differentiation. SWI/SNF complex subunit mutations occur in more than 20% of malignant tumors. This article reviews the role and characteristics of this complex and its subunits in malignant tumors, and explores the potential clinical application of SWI/SNF complexes in tumor therapy. |
| first_indexed | 2024-04-12T21:29:15Z |
| format | Article |
| id | doaj.art-6d607b32ca034a4cb362f70943b4f43e |
| institution | Directory Open Access Journal |
| issn | 1000-8578 1000-8578 |
| language | zho |
| last_indexed | 2024-04-12T21:29:15Z |
| publishDate | 2019-07-01 |
| publisher | Magazine House of Cancer Research on Prevention and Treatment |
| record_format | Article |
| series | Zhongliu Fangzhi Yanjiu |
| spelling | doaj.art-6d607b32ca034a4cb362f70943b4f43e2022-12-22T03:16:06ZzhoMagazine House of Cancer Research on Prevention and TreatmentZhongliu Fangzhi Yanjiu1000-85781000-85782019-07-0146764464910.3971/j.issn.1000-8578.2019.18.18718578.2019.18.1871Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic StrategiesGUO Qing0RAO Qiu1ZHOU Zhiyi2Department of Pathology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, ChinaDepartment of Pathology, Nanjing General Hospital of PLA, Nanjing 210002, ChinaDepartment of Pathology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, ChinaThe SWI/SNF complex is an important multi-subunit protein complex that regulates gene expression in eukaryotic cells. It is widely involved in various biological processes such as signal transduction, cell cycle and cell differentiation. SWI/SNF complex subunit mutations occur in more than 20% of malignant tumors. This article reviews the role and characteristics of this complex and its subunits in malignant tumors, and explores the potential clinical application of SWI/SNF complexes in tumor therapy.http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.1871.htmmalignant tumorswi/snf complexcarcinogenic mechanismtreatment strategy |
| spellingShingle | GUO Qing RAO Qiu ZHOU Zhiyi Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies Zhongliu Fangzhi Yanjiu malignant tumor swi/snf complex carcinogenic mechanism treatment strategy |
| title | Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies |
| title_full | Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies |
| title_fullStr | Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies |
| title_full_unstemmed | Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies |
| title_short | Role of SWI/SNF Complex Subunit Abnormality in Tumors and Progress of Related Therapeutic Strategies |
| title_sort | role of swi snf complex subunit abnormality in tumors and progress of related therapeutic strategies |
| topic | malignant tumor swi/snf complex carcinogenic mechanism treatment strategy |
| url | http://html.rhhz.net/ZLFZYJ/html/8578.2019.18.1871.htm |
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