Structural properties of the HNF-1A transactivation domain

Structural properties of the HNF-1A transactivation domain

Hepatocyte nuclear factor 1α (HNF-1A) is a transcription factor with important gene regulatory roles in pancreatic β-cells. HNF1A gene variants are associated with a monogenic form of diabetes (HNF1A-MODY) or an increased risk for type 2 diabetes. While several pancreatic target genes of HNF-1A have...

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Bibliographic Details
Main Authors: Laura Kind, Mark Driver, Arne Raasakka, Patrick R. Onck, Pål Rasmus Njølstad, Thomas Arnesen, Petri Kursula
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
β-cell
diabetes
transcription factor
HNF-1A
MODY
intrinsically disordered protein
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1249939/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1249939/full

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