Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants
BackgroundThe neonatal sequential organ failure assessment (nSOFA) score is an operational definition of organ dysfunction employed to predict sepsis-associated mortality. However, the relationship between the nSOFA score and bronchopulmonary dysplasia (BPD) has not been investigated clearly. This s...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2023.1233189/full |
| _version_ | 1797670788025810944 |
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| author | Doudou Xu Ziwei Dong Xiaoli Yin Yuanyuan Yang Yang Wang |
| author_facet | Doudou Xu Ziwei Dong Xiaoli Yin Yuanyuan Yang Yang Wang |
| author_sort | Doudou Xu |
| collection | DOAJ |
| description | BackgroundThe neonatal sequential organ failure assessment (nSOFA) score is an operational definition of organ dysfunction employed to predict sepsis-associated mortality. However, the relationship between the nSOFA score and bronchopulmonary dysplasia (BPD) has not been investigated clearly. This study evaluates whether the nSOFA score within 72 h after delivery could be used to predict the occurrence of BPD in very preterm infants.MethodsIn this retrospective, single-center cohort study, preterm infants born between 2019 and 2021 were investigated, the nSOFA score was calculated from medical records after admission to the neonatal intensive care unit (NICU) within 72 h after delivery, and the peak value was used for calculation. A logistic regression model was used to evaluate the relationship between the nSOFA score and BPD. Propensity score matching and subgroup analysis were performed to verify the reliability of the results.ResultsOf 238 infants meeting the inclusion criteria, 93 infants (39.1%) were diagnosed with BPD. The receiver operating characteristic curve of the nSOFA score in predicting BPD was 0.790 [95% confidence interval (CI): 0.731–0.849]. The logistic regression model showed that an increment of one in the nSOFA score was related to a 2.09-fold increase in the odds of BPD (95% CI: 1.57–2.76) and 6.36-fold increase when the nSOFA score was higher than 1.5 (95% CI: 2.73–14.79).ConclusionsThe nSOFA score within 72 h after delivery is independently related to BPD and can be used to identify high-risk infants and implement early interventions. |
| first_indexed | 2024-03-11T21:05:41Z |
| format | Article |
| id | doaj.art-6d6436add681476eb27fd32211259b3f |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-11T21:05:41Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-6d6436add681476eb27fd32211259b3f2023-09-29T13:59:20ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602023-09-011110.3389/fped.2023.12331891233189Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infantsDoudou XuZiwei DongXiaoli YinYuanyuan YangYang WangBackgroundThe neonatal sequential organ failure assessment (nSOFA) score is an operational definition of organ dysfunction employed to predict sepsis-associated mortality. However, the relationship between the nSOFA score and bronchopulmonary dysplasia (BPD) has not been investigated clearly. This study evaluates whether the nSOFA score within 72 h after delivery could be used to predict the occurrence of BPD in very preterm infants.MethodsIn this retrospective, single-center cohort study, preterm infants born between 2019 and 2021 were investigated, the nSOFA score was calculated from medical records after admission to the neonatal intensive care unit (NICU) within 72 h after delivery, and the peak value was used for calculation. A logistic regression model was used to evaluate the relationship between the nSOFA score and BPD. Propensity score matching and subgroup analysis were performed to verify the reliability of the results.ResultsOf 238 infants meeting the inclusion criteria, 93 infants (39.1%) were diagnosed with BPD. The receiver operating characteristic curve of the nSOFA score in predicting BPD was 0.790 [95% confidence interval (CI): 0.731–0.849]. The logistic regression model showed that an increment of one in the nSOFA score was related to a 2.09-fold increase in the odds of BPD (95% CI: 1.57–2.76) and 6.36-fold increase when the nSOFA score was higher than 1.5 (95% CI: 2.73–14.79).ConclusionsThe nSOFA score within 72 h after delivery is independently related to BPD and can be used to identify high-risk infants and implement early interventions.https://www.frontiersin.org/articles/10.3389/fped.2023.1233189/fullneonatal sequential organ failure assessmentpremature infantsbronchopulmonary dysplasianeonatal intensive care unitpredict |
| spellingShingle | Doudou Xu Ziwei Dong Xiaoli Yin Yuanyuan Yang Yang Wang Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants Frontiers in Pediatrics neonatal sequential organ failure assessment premature infants bronchopulmonary dysplasia neonatal intensive care unit predict |
| title | Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants |
| title_full | Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants |
| title_fullStr | Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants |
| title_full_unstemmed | Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants |
| title_short | Neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants |
| title_sort | neonatal sequential organ failure assessment score within 72 h after delivery reliably predicts bronchopulmonary dysplasia in very preterm infants |
| topic | neonatal sequential organ failure assessment premature infants bronchopulmonary dysplasia neonatal intensive care unit predict |
| url | https://www.frontiersin.org/articles/10.3389/fped.2023.1233189/full |
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