Mitochondria in Health and Diseases
Mitochondria are subcellular organelles evolved by endosymbiosis of bacteria with eukaryotic cells characteristics. They are the main source of ATP in the cell and play a pivotal role in cell life and cell death. Mitochondria are engaged in the pathogenesis of human diseases and aging directly or in...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/5/1177 |
| _version_ | 1797568478072274944 |
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| author | Sabzali Javadov Andrey V. Kozlov Amadou K. S. Camara |
| author_facet | Sabzali Javadov Andrey V. Kozlov Amadou K. S. Camara |
| author_sort | Sabzali Javadov |
| collection | DOAJ |
| description | Mitochondria are subcellular organelles evolved by endosymbiosis of bacteria with eukaryotic cells characteristics. They are the main source of ATP in the cell and play a pivotal role in cell life and cell death. Mitochondria are engaged in the pathogenesis of human diseases and aging directly or indirectly through a broad range of signaling pathways. However, despite an increased interest in mitochondria over the past decades, the mechanisms of mitochondria-mediated cell/organ dysfunction in response to pathological stimuli remain unknown. The Special Issue, “Mitochondria in Health and Diseases,” organized by <i>Cells</i> includes 24 review and original articles that highlight the latest achievements in elucidating the role of mitochondria under physiological (healthy) conditions and, in various cell/animal models of human diseases and, in patients. Altogether, the Special Issue summarizes and discusses different aspects of mitochondrial metabolism and function that open new avenues in understanding mitochondrial biology. |
| first_indexed | 2024-03-10T19:57:28Z |
| format | Article |
| id | doaj.art-6d66a3f8540b4c7fa5adf75c5dd240d3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:57:28Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-6d66a3f8540b4c7fa5adf75c5dd240d32023-11-19T23:52:54ZengMDPI AGCells2073-44092020-05-0195117710.3390/cells9051177Mitochondria in Health and DiseasesSabzali Javadov0Andrey V. Kozlov1Amadou K. S. Camara2Department of Physiology, School of Medicine, University of Puerto Rico, San Juan, PR 00936-5067, USALudwig Boltzmann Institute for Experimental and Clinical Traumatology, 1200 Vienna, AustriaDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USAMitochondria are subcellular organelles evolved by endosymbiosis of bacteria with eukaryotic cells characteristics. They are the main source of ATP in the cell and play a pivotal role in cell life and cell death. Mitochondria are engaged in the pathogenesis of human diseases and aging directly or indirectly through a broad range of signaling pathways. However, despite an increased interest in mitochondria over the past decades, the mechanisms of mitochondria-mediated cell/organ dysfunction in response to pathological stimuli remain unknown. The Special Issue, “Mitochondria in Health and Diseases,” organized by <i>Cells</i> includes 24 review and original articles that highlight the latest achievements in elucidating the role of mitochondria under physiological (healthy) conditions and, in various cell/animal models of human diseases and, in patients. Altogether, the Special Issue summarizes and discusses different aspects of mitochondrial metabolism and function that open new avenues in understanding mitochondrial biology.https://www.mdpi.com/2073-4409/9/5/1177mitochondriaenergy metabolismsignaling pathwaysion homeostasishuman diseases |
| spellingShingle | Sabzali Javadov Andrey V. Kozlov Amadou K. S. Camara Mitochondria in Health and Diseases Cells mitochondria energy metabolism signaling pathways ion homeostasis human diseases |
| title | Mitochondria in Health and Diseases |
| title_full | Mitochondria in Health and Diseases |
| title_fullStr | Mitochondria in Health and Diseases |
| title_full_unstemmed | Mitochondria in Health and Diseases |
| title_short | Mitochondria in Health and Diseases |
| title_sort | mitochondria in health and diseases |
| topic | mitochondria energy metabolism signaling pathways ion homeostasis human diseases |
| url | https://www.mdpi.com/2073-4409/9/5/1177 |
| work_keys_str_mv | AT sabzalijavadov mitochondriainhealthanddiseases AT andreyvkozlov mitochondriainhealthanddiseases AT amadoukscamara mitochondriainhealthanddiseases |