Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options
The gut microbiota is critical for maintaining human health and the immunological system. Several neuroscientific studies have shown the significance of microbiota in developing brain systems. The gut microbiota and the brain are interconnected in a bidirectional relationship, as research on the mic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/4/565 |
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| author | Akash Kumar Jhilam Pramanik Nandani Goyal Dimple Chauhan Bhagavathi Sundaram Sivamaruthi Bhupendra G. Prajapati Chaiyavat Chaiyasut |
| author_facet | Akash Kumar Jhilam Pramanik Nandani Goyal Dimple Chauhan Bhagavathi Sundaram Sivamaruthi Bhupendra G. Prajapati Chaiyavat Chaiyasut |
| author_sort | Akash Kumar |
| collection | DOAJ |
| description | The gut microbiota is critical for maintaining human health and the immunological system. Several neuroscientific studies have shown the significance of microbiota in developing brain systems. The gut microbiota and the brain are interconnected in a bidirectional relationship, as research on the microbiome–gut–brain axis shows. Significant evidence links anxiety and depression disorders to the community of microbes that live in the gastrointestinal system. Modified diet, fish and omega-3 fatty acid intake, macro- and micro-nutrient intake, prebiotics, probiotics, synbiotics, postbiotics, fecal microbiota transplantation, and 5-HTP regulation may all be utilized to alter the gut microbiota as a treatment approach. There are few preclinical and clinical research studies on the effectiveness and reliability of various therapeutic approaches for depression and anxiety. This article highlights relevant research on the association of gut microbiota with depression and anxiety and the different therapeutic possibilities of gut microbiota modification. |
| first_indexed | 2024-03-11T04:39:20Z |
| format | Article |
| id | doaj.art-6d6769339aae4c4f91b1556f67ed183a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T04:39:20Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-6d6769339aae4c4f91b1556f67ed183a2023-11-17T20:50:43ZengMDPI AGPharmaceuticals1424-82472023-04-0116456510.3390/ph16040565Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management OptionsAkash Kumar0Jhilam Pramanik1Nandani Goyal2Dimple Chauhan3Bhagavathi Sundaram Sivamaruthi4Bhupendra G. Prajapati5Chaiyavat Chaiyasut6Department of Food Technology, SRM University, Sonipat 131029, IndiaDepartment of Food Technology, ITM University, Gwalior 474001, IndiaDepartment of Skill Agriculture, Shri Vishwakarma Skill University, Gurugram 122003, IndiaSchool of Bio-Engineering and Food Technology, Shoolini University, Solan 173229, IndiaOffice of Research Administration, Chiang Mai University, Chiang Mai 50200, ThailandShree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Mehsana 384012, IndiaInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, ThailandThe gut microbiota is critical for maintaining human health and the immunological system. Several neuroscientific studies have shown the significance of microbiota in developing brain systems. The gut microbiota and the brain are interconnected in a bidirectional relationship, as research on the microbiome–gut–brain axis shows. Significant evidence links anxiety and depression disorders to the community of microbes that live in the gastrointestinal system. Modified diet, fish and omega-3 fatty acid intake, macro- and micro-nutrient intake, prebiotics, probiotics, synbiotics, postbiotics, fecal microbiota transplantation, and 5-HTP regulation may all be utilized to alter the gut microbiota as a treatment approach. There are few preclinical and clinical research studies on the effectiveness and reliability of various therapeutic approaches for depression and anxiety. This article highlights relevant research on the association of gut microbiota with depression and anxiety and the different therapeutic possibilities of gut microbiota modification.https://www.mdpi.com/1424-8247/16/4/565gut–brain axismicrobiotaanxietydepressionprobiotics |
| spellingShingle | Akash Kumar Jhilam Pramanik Nandani Goyal Dimple Chauhan Bhagavathi Sundaram Sivamaruthi Bhupendra G. Prajapati Chaiyavat Chaiyasut Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options Pharmaceuticals gut–brain axis microbiota anxiety depression probiotics |
| title | Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options |
| title_full | Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options |
| title_fullStr | Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options |
| title_full_unstemmed | Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options |
| title_short | Gut Microbiota in Anxiety and Depression: Unveiling the Relationships and Management Options |
| title_sort | gut microbiota in anxiety and depression unveiling the relationships and management options |
| topic | gut–brain axis microbiota anxiety depression probiotics |
| url | https://www.mdpi.com/1424-8247/16/4/565 |
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