Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET

Potential Mechanism for HIV-Associated Depression: Upregulation of Serotonin Transporters in SIV-Infected Macaques Detected by 11C-DASB PET

Purpose: Increased incidence of depression in HIV+ patients is associated with lower adherence to treatment and increased morbidity/mortality. One possible underlying pathophysiology is serotonergic dysfunction. In this study, we used an animal model of HIV, the SIV-infected macaque, to longitudinal...

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Main Authors: Swati Shah, Sanhita Sinharay, Kenta Matsuda, William Schreiber-Stainthorp, Siva Muthusamy, Dianne Lee, Paul Wakim, Vanessa Hirsch, Avindra Nath, Michele Di Mascio, Dima A. Hammoud
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Psychiatry
Subjects:
HIV
SIV
depression
serotonin transporter
PET
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2019.00362/full

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