Osteopontin Levels in Patients with Squamous Metastatic Head and Neck Cancer
<i>Background and Objectives</i>: Increased osteopontin (OPN) concentrations in the plasma of patients with head and neck squamous cancer (HNSCC) have diagnostic significance, and it can indicate more aggressive biological behavior of cancer. The aim of this study was to determine OPN le...
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MDPI AG
2021-02-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/57/2/185 |
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| author | Josip Maleš Hrvoje Mihalj Anamarija Šestak Kristina Kralik Martina Smolić |
| author_facet | Josip Maleš Hrvoje Mihalj Anamarija Šestak Kristina Kralik Martina Smolić |
| author_sort | Josip Maleš |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: Increased osteopontin (OPN) concentrations in the plasma of patients with head and neck squamous cancer (HNSCC) have diagnostic significance, and it can indicate more aggressive biological behavior of cancer. The aim of this study was to determine OPN levels in patients with HNSCC of different primary locations and to assess its prognostic significance in metastasis development. <i>Materials and Methods</i>: This cohort study included 45 patients (41 male and 4 female patients) with HNSCC with different primary localization of head and neck. All patients underwent surgery—neck dissection. All patients were categorized according to the histological findings of the resected material and tumor–node–metastasis (TNM) classification system. After surgery, N categories were determined on the basis of histological features of resected material. <i>Results</i>: The histological findings of our patients showed: N0 in 11 patients, N1 in 8 patients, N2a in 4 patients, N2b in 14 patients and N2c in 8 patients. Plasma OPN values in all study participants ranged from 2.24 to 109.10 ng/mL. OPN levels in plasma of patients with negative nodes compared to the group of patients with positive nodes in the neck differed significantly (16.89 ng/mL to 34.08 ng/mL, respectively; <i>p</i> = 0.03). There were significantly lower OPN plasma levels in the group of subjects with histologically positive one lymph node in the neck (N1) compared to the group of patients with N2b histologically positive findings of resected neck material (10.4 ng/mL to 43.9 ng/mL, respectively; <i>p</i> = 0.02). <i>Conclusions</i>: The results have shown that growing N degrees of positive neck nodes classification were accompanied by growing values of plasma osteopontin. Osteopontin might be important for the development of neck metastases. |
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| language | English |
| last_indexed | 2024-03-12T08:31:48Z |
| publishDate | 2021-02-01 |
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| series | Medicina |
| spelling | doaj.art-6d6931421a19483693f2bbc09d7ad4012023-09-02T17:32:33ZengMDPI AGMedicina1010-660X2021-02-015718518510.3390/medicina57020185Osteopontin Levels in Patients with Squamous Metastatic Head and Neck CancerJosip Maleš0Hrvoje Mihalj1Anamarija Šestak2Kristina Kralik3Martina Smolić4Department of Otorhinolaryngology and Maxillofacial Surgery, Medical Faculty, University of Osijek, J. Huttlera 4, 31000 Osijek, CroatiaDepartment of Otorhinolaryngology and Maxillofacial Surgery, Medical Faculty, University of Osijek, J. Huttlera 4, 31000 Osijek, CroatiaDepartment of Otorhinolaryngology and Head and Neck Surgery, University Clinical Hospital Centre Osijek, J. Huttlera 4, 31000 Osijek, CroatiaFaculty of Medicine Osijek, University of Osijek, J. Huttlera 4, 31000 Osijek, CroatiaDepartment of Pharmacology, Faculty of Medicine, University of Osijek, J. Huttlera 4, 31000 Osijek, Croatia<i>Background and Objectives</i>: Increased osteopontin (OPN) concentrations in the plasma of patients with head and neck squamous cancer (HNSCC) have diagnostic significance, and it can indicate more aggressive biological behavior of cancer. The aim of this study was to determine OPN levels in patients with HNSCC of different primary locations and to assess its prognostic significance in metastasis development. <i>Materials and Methods</i>: This cohort study included 45 patients (41 male and 4 female patients) with HNSCC with different primary localization of head and neck. All patients underwent surgery—neck dissection. All patients were categorized according to the histological findings of the resected material and tumor–node–metastasis (TNM) classification system. After surgery, N categories were determined on the basis of histological features of resected material. <i>Results</i>: The histological findings of our patients showed: N0 in 11 patients, N1 in 8 patients, N2a in 4 patients, N2b in 14 patients and N2c in 8 patients. Plasma OPN values in all study participants ranged from 2.24 to 109.10 ng/mL. OPN levels in plasma of patients with negative nodes compared to the group of patients with positive nodes in the neck differed significantly (16.89 ng/mL to 34.08 ng/mL, respectively; <i>p</i> = 0.03). There were significantly lower OPN plasma levels in the group of subjects with histologically positive one lymph node in the neck (N1) compared to the group of patients with N2b histologically positive findings of resected neck material (10.4 ng/mL to 43.9 ng/mL, respectively; <i>p</i> = 0.02). <i>Conclusions</i>: The results have shown that growing N degrees of positive neck nodes classification were accompanied by growing values of plasma osteopontin. Osteopontin might be important for the development of neck metastases.https://www.mdpi.com/1010-660X/57/2/185squamous cancerosteopontinneck metastases |
| spellingShingle | Josip Maleš Hrvoje Mihalj Anamarija Šestak Kristina Kralik Martina Smolić Osteopontin Levels in Patients with Squamous Metastatic Head and Neck Cancer Medicina squamous cancer osteopontin neck metastases |
| title | Osteopontin Levels in Patients with Squamous Metastatic Head and Neck Cancer |
| title_full | Osteopontin Levels in Patients with Squamous Metastatic Head and Neck Cancer |
| title_fullStr | Osteopontin Levels in Patients with Squamous Metastatic Head and Neck Cancer |
| title_full_unstemmed | Osteopontin Levels in Patients with Squamous Metastatic Head and Neck Cancer |
| title_short | Osteopontin Levels in Patients with Squamous Metastatic Head and Neck Cancer |
| title_sort | osteopontin levels in patients with squamous metastatic head and neck cancer |
| topic | squamous cancer osteopontin neck metastases |
| url | https://www.mdpi.com/1010-660X/57/2/185 |
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