A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASH
Recently, some preclinical and clinical studies have demonstrated the ability of brown seaweeds in reducing the risk factors for metabolic syndrome. Here, we analyzed the beneficial effect of a nutraceutical formulation containing a phytocomplex extracted from seaweeds and chromium picolinate in ani...
Main Authors: | , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-09-01
|
Series: | Marine Drugs |
Subjects: | |
Online Access: | https://www.mdpi.com/1660-3397/20/9/572 |
_version_ | 1797485491080134656 |
---|---|
author | Daniela Gabbia Marco Roverso Ilaria Zanotto Martina Colognesi Katia Sayaf Samantha Sarcognato Diletta Arcidiacono Alice Zaramella Stefano Realdon Nicola Ferri Maria Guido Francesco Paolo Russo Sara Bogialli Maria Carrara Sara De Martin |
author_facet | Daniela Gabbia Marco Roverso Ilaria Zanotto Martina Colognesi Katia Sayaf Samantha Sarcognato Diletta Arcidiacono Alice Zaramella Stefano Realdon Nicola Ferri Maria Guido Francesco Paolo Russo Sara Bogialli Maria Carrara Sara De Martin |
author_sort | Daniela Gabbia |
collection | DOAJ |
description | Recently, some preclinical and clinical studies have demonstrated the ability of brown seaweeds in reducing the risk factors for metabolic syndrome. Here, we analyzed the beneficial effect of a nutraceutical formulation containing a phytocomplex extracted from seaweeds and chromium picolinate in animal models of liver steatosis of differing severities (rats with non-alcoholic fatty liver disease (NAFLD) and its complication, non-alcoholic steatohepatitis (NASH)). This treatment led to a significant drop in hepatic fat deposition in both models (<i>p</i> < 0.01 vs. untreated animals), accompanied by a reduction in plasma inflammatory cytokines, such as interleukin 6, tumor necrosis factor α, and C reactive protein, and myeloperoxidase expression in liver tissue. Furthermore, a modulation of the molecular pathways involved in lipid metabolism and storage was demonstrated, since we observed the significant reduction of the mRNA levels of fatty acid synthase, diacylglycerol acyltransferases, the sterol-binding protein SREBP-1, and the lipid transporter perilipin-2, in both treated NAFLD and NASH rats in comparison to untreated ones. In conclusion, this nutraceutical product was effective in reducing liver steatosis and showed further beneficial effects on hepatic inflammation and glycemic control, which were particularly evident in rats characterized by a more severe condition, thus representing a therapeutic option for the treatment of NAFLD and NASH patients. |
first_indexed | 2024-03-09T23:19:33Z |
format | Article |
id | doaj.art-6d69afb62a0a44eaa5ab0b5c94c2e6d0 |
institution | Directory Open Access Journal |
issn | 1660-3397 |
language | English |
last_indexed | 2024-03-09T23:19:33Z |
publishDate | 2022-09-01 |
publisher | MDPI AG |
record_format | Article |
series | Marine Drugs |
spelling | doaj.art-6d69afb62a0a44eaa5ab0b5c94c2e6d02023-11-23T17:28:53ZengMDPI AGMarine Drugs1660-33972022-09-0120957210.3390/md20090572A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASHDaniela Gabbia0Marco Roverso1Ilaria Zanotto2Martina Colognesi3Katia Sayaf4Samantha Sarcognato5Diletta Arcidiacono6Alice Zaramella7Stefano Realdon8Nicola Ferri9Maria Guido10Francesco Paolo Russo11Sara Bogialli12Maria Carrara13Sara De Martin14Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, ItalyDepartment of Chemical Sciences, University of Padova, 35131 Padova, ItalyDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, ItalyDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, ItalyDepartment of Surgery, Oncology and Gastroenterology, University of Padova, 35131 Padova, ItalyDepartment of Pathology, Azienda ULSS2 Marca Trevigiana, 31100 Treviso, ItalyGastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, 35131 Padova, ItalyDepartment of Surgery, Oncology and Gastroenterology, University of Padova, 35131 Padova, ItalyGastroenterology Unit, Veneto Institute of Oncology IOV-IRCCS, 35131 Padova, ItalyDepartment of Medicine, University of Padova, 35131 Padova, ItalyDepartment of Pathology, Azienda ULSS2 Marca Trevigiana, 31100 Treviso, ItalyDepartment of Surgery, Oncology and Gastroenterology, University of Padova, 35131 Padova, ItalyDepartment of Chemical Sciences, University of Padova, 35131 Padova, ItalyDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, ItalyDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, 35131 Padova, ItalyRecently, some preclinical and clinical studies have demonstrated the ability of brown seaweeds in reducing the risk factors for metabolic syndrome. Here, we analyzed the beneficial effect of a nutraceutical formulation containing a phytocomplex extracted from seaweeds and chromium picolinate in animal models of liver steatosis of differing severities (rats with non-alcoholic fatty liver disease (NAFLD) and its complication, non-alcoholic steatohepatitis (NASH)). This treatment led to a significant drop in hepatic fat deposition in both models (<i>p</i> < 0.01 vs. untreated animals), accompanied by a reduction in plasma inflammatory cytokines, such as interleukin 6, tumor necrosis factor α, and C reactive protein, and myeloperoxidase expression in liver tissue. Furthermore, a modulation of the molecular pathways involved in lipid metabolism and storage was demonstrated, since we observed the significant reduction of the mRNA levels of fatty acid synthase, diacylglycerol acyltransferases, the sterol-binding protein SREBP-1, and the lipid transporter perilipin-2, in both treated NAFLD and NASH rats in comparison to untreated ones. In conclusion, this nutraceutical product was effective in reducing liver steatosis and showed further beneficial effects on hepatic inflammation and glycemic control, which were particularly evident in rats characterized by a more severe condition, thus representing a therapeutic option for the treatment of NAFLD and NASH patients.https://www.mdpi.com/1660-3397/20/9/572NAFLDNASHbrown seaweedalgal extractsteatosis<i>Ascophyllum nodosum</i> |
spellingShingle | Daniela Gabbia Marco Roverso Ilaria Zanotto Martina Colognesi Katia Sayaf Samantha Sarcognato Diletta Arcidiacono Alice Zaramella Stefano Realdon Nicola Ferri Maria Guido Francesco Paolo Russo Sara Bogialli Maria Carrara Sara De Martin A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASH Marine Drugs NAFLD NASH brown seaweed algal extract steatosis <i>Ascophyllum nodosum</i> |
title | A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASH |
title_full | A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASH |
title_fullStr | A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASH |
title_full_unstemmed | A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASH |
title_short | A Nutraceutical Formulation Containing Brown Algae Reduces Hepatic Lipid Accumulation by Modulating Lipid Metabolism and Inflammation in Experimental Models of NAFLD and NASH |
title_sort | nutraceutical formulation containing brown algae reduces hepatic lipid accumulation by modulating lipid metabolism and inflammation in experimental models of nafld and nash |
topic | NAFLD NASH brown seaweed algal extract steatosis <i>Ascophyllum nodosum</i> |
url | https://www.mdpi.com/1660-3397/20/9/572 |
work_keys_str_mv | AT danielagabbia anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT marcoroverso anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT ilariazanotto anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT martinacolognesi anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT katiasayaf anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT samanthasarcognato anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT dilettaarcidiacono anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT alicezaramella anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT stefanorealdon anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT nicolaferri anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT mariaguido anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT francescopaolorusso anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT sarabogialli anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT mariacarrara anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT sarademartin anutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT danielagabbia nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT marcoroverso nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT ilariazanotto nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT martinacolognesi nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT katiasayaf nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT samanthasarcognato nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT dilettaarcidiacono nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT alicezaramella nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT stefanorealdon nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT nicolaferri nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT mariaguido nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT francescopaolorusso nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT sarabogialli nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT mariacarrara nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash AT sarademartin nutraceuticalformulationcontainingbrownalgaereduceshepaticlipidaccumulationbymodulatinglipidmetabolismandinflammationinexperimentalmodelsofnafldandnash |