Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/Obesity
Dunmin She,1,2,* Wei Xu,3,* Jing Liu,4,* Zikai Zhang,5 Ping Fang,3 Ran Li,3 Dehong Kong,3 Miao Xuan,3 Qi Liu,3 Mo Yuan Pan,6 Yan Wang,1,2 Ying Xue3 1Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 2Department of Endocrinology, Nor...
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-09-01
|
| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/serum-uric-acid-to-creatinine-ratio-and-risk-of-metabolic-syndrome-in--peer-reviewed-fulltext-article-DMSO |
| _version_ | 1797671533021233152 |
|---|---|
| author | She D Xu W Liu J Zhang Z Fang P Li R Kong D Xuan M Liu Q Pan MY Wang Y Xue Y |
| author_facet | She D Xu W Liu J Zhang Z Fang P Li R Kong D Xuan M Liu Q Pan MY Wang Y Xue Y |
| author_sort | She D |
| collection | DOAJ |
| description | Dunmin She,1,2,* Wei Xu,3,* Jing Liu,4,* Zikai Zhang,5 Ping Fang,3 Ran Li,3 Dehong Kong,3 Miao Xuan,3 Qi Liu,3 Mo Yuan Pan,6 Yan Wang,1,2 Ying Xue3 1Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 2Department of Endocrinology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 3Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 4Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 5Department of Oncology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 6The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Xue, Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, No. 389, Xincun Road, Shanghai, People’s Republic of China, Tel +86-21-66111061, Email doxy0622@163.com Yan Wang, Clinical Medical College, Yangzhou University, No. 98, Nantong West Road, Yangzhou, Jiangsu Province, People’s Republic of China, Email yzyan1972@126.comPurpose: Metabolic syndrome (MetS) is a rising global concern with an increasing prevalence. This study aimed to evaluate the relationship between serum uric acid to creatinine ratio (SUA/Cr) and MetS in adults with overweight/obesity in China.Patients and Methods: We conducted a cross-sectional study comprising 4699 participants with overweight/obesity who underwent physical examinations. Their serum levels of various components, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), fasting plasma glucose (FPG), creatinine (Cr), and uric acid (UA) were measured. Renal function-normalized SUA was calculated using SUA/Cr. Logistic regression analysis was employed to investigate the association between SUA/Cr and MetS in adults with overweight/obesity.Results: SUA/Cr levels were lower in non-MetS participants (OR: 2.159, 95% CI: 1.82 to 2.56; p < 0.001), and tended to rise with the increasing number of MetS components. Additionally, elevated SUA/Cr levels were associated with a higher risk of hypertension, hyperglycemia, and dyslipidemia.Conclusion: SUA/Cr levels were significantly associated with MetS and its components in Chinese adults with overweight/obesity.Keywords: metabolic syndrome, serum uric acid to creatinine ratio, overweight/obesity |
| first_indexed | 2024-03-11T21:16:55Z |
| format | Article |
| id | doaj.art-6d69d5ff940847a8bb275e88bb377094 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-03-11T21:16:55Z |
| publishDate | 2023-09-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-6d69d5ff940847a8bb275e88bb3770942023-09-28T18:12:52ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072023-09-01Volume 163007301787038Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/ObesityShe DXu WLiu JZhang ZFang PLi RKong DXuan MLiu QPan MYWang YXue YDunmin She,1,2,* Wei Xu,3,* Jing Liu,4,* Zikai Zhang,5 Ping Fang,3 Ran Li,3 Dehong Kong,3 Miao Xuan,3 Qi Liu,3 Mo Yuan Pan,6 Yan Wang,1,2 Ying Xue3 1Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 2Department of Endocrinology, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Yangzhou, Jiangsu, People’s Republic of China; 3Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 4Dalian Medical University, Dalian, Liaoning, People’s Republic of China; 5Department of Oncology, Tongji Hospital, School of Medicine, Tongji University, Shanghai, People’s Republic of China; 6The Second Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Xue, Department of Endocrinology and Metabolism, Tongji Hospital, School of Medicine, Tongji University, No. 389, Xincun Road, Shanghai, People’s Republic of China, Tel +86-21-66111061, Email doxy0622@163.com Yan Wang, Clinical Medical College, Yangzhou University, No. 98, Nantong West Road, Yangzhou, Jiangsu Province, People’s Republic of China, Email yzyan1972@126.comPurpose: Metabolic syndrome (MetS) is a rising global concern with an increasing prevalence. This study aimed to evaluate the relationship between serum uric acid to creatinine ratio (SUA/Cr) and MetS in adults with overweight/obesity in China.Patients and Methods: We conducted a cross-sectional study comprising 4699 participants with overweight/obesity who underwent physical examinations. Their serum levels of various components, including total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), fasting plasma glucose (FPG), creatinine (Cr), and uric acid (UA) were measured. Renal function-normalized SUA was calculated using SUA/Cr. Logistic regression analysis was employed to investigate the association between SUA/Cr and MetS in adults with overweight/obesity.Results: SUA/Cr levels were lower in non-MetS participants (OR: 2.159, 95% CI: 1.82 to 2.56; p < 0.001), and tended to rise with the increasing number of MetS components. Additionally, elevated SUA/Cr levels were associated with a higher risk of hypertension, hyperglycemia, and dyslipidemia.Conclusion: SUA/Cr levels were significantly associated with MetS and its components in Chinese adults with overweight/obesity.Keywords: metabolic syndrome, serum uric acid to creatinine ratio, overweight/obesityhttps://www.dovepress.com/serum-uric-acid-to-creatinine-ratio-and-risk-of-metabolic-syndrome-in--peer-reviewed-fulltext-article-DMSOmetabolic syndromeserum uric acid to creatinine ratiooverweight/obesity |
| spellingShingle | She D Xu W Liu J Zhang Z Fang P Li R Kong D Xuan M Liu Q Pan MY Wang Y Xue Y Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/Obesity Diabetes, Metabolic Syndrome and Obesity metabolic syndrome serum uric acid to creatinine ratio overweight/obesity |
| title | Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/Obesity |
| title_full | Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/Obesity |
| title_fullStr | Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/Obesity |
| title_full_unstemmed | Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/Obesity |
| title_short | Serum Uric Acid to Creatinine Ratio and Risk of Metabolic Syndrome in Patients with Overweight/Obesity |
| title_sort | serum uric acid to creatinine ratio and risk of metabolic syndrome in patients with overweight obesity |
| topic | metabolic syndrome serum uric acid to creatinine ratio overweight/obesity |
| url | https://www.dovepress.com/serum-uric-acid-to-creatinine-ratio-and-risk-of-metabolic-syndrome-in--peer-reviewed-fulltext-article-DMSO |
| work_keys_str_mv | AT shed serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT xuw serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT liuj serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT zhangz serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT fangp serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT lir serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT kongd serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT xuanm serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT liuq serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT panmy serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT wangy serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity AT xuey serumuricacidtocreatinineratioandriskofmetabolicsyndromeinpatientswithoverweightobesity |