The chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.

The chromosomal association of the Smc5/6 complex depends on cohesion and predicts the level of sister chromatid entanglement.

The cohesin complex, which is essential for sister chromatid cohesion and chromosome segregation, also inhibits resolution of sister chromatid intertwinings (SCIs) by the topoisomerase Top2. The cohesin-related Smc5/6 complex (Smc5/6) instead accumulates on chromosomes after Top2 inactivation, known...

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Main Authors: Kristian Jeppsson, Kristian K Carlborg, Ryuichiro Nakato, Davide G Berta, Ingrid Lilienthal, Takaharu Kanno, Arne Lindqvist, Maartje C Brink, Nico P Dantuma, Yuki Katou, Katsuhiko Shirahige, Camilla Sjögren
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC4199498?pdf=render

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