Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery
Bruce Parsons,1 Qijiang Zhu,2 Li Xie,3 Chunming Li,1 Raymond Cheung1 1Pfizer Inc, New York, NY, USA; 281st Hospital of Chinese People’s Liberation Army, Nanjing, People’s Republic of China; 3Pfizer Investment Co., Ltd, Beijing, People’s Republic of China Object...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2016-11-01
|
| Series: | Journal of Pain Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/effects-of-parecoxib-on-postoperative-pain-and-opioid-related-symptoms-peer-reviewed-article-JPR |
| _version_ | 1818310252432457728 |
|---|---|
| author | Parsons B Zhu Q Xie L Li C Cheung R |
| author_facet | Parsons B Zhu Q Xie L Li C Cheung R |
| author_sort | Parsons B |
| collection | DOAJ |
| description | Bruce Parsons,1 Qijiang Zhu,2 Li Xie,3 Chunming Li,1 Raymond Cheung1 1Pfizer Inc, New York, NY, USA; 281st Hospital of Chinese People’s Liberation Army, Nanjing, People’s Republic of China; 3Pfizer Investment Co., Ltd, Beijing, People’s Republic of China Objective: To examine the analgesic and opioid-sparing effects of parecoxib following major gynecologic surgery.Methods: This is a large subset analysis of patients from a multicenter, randomized, double-blind, placebo-controlled study of parecoxib/valdecoxib (PAR/VAL) for postoperative pain. Pain severity, pain interference with function, opioid use, occurrence of opioid-related symptoms, and Patient/Physician Global Evaluation of Study Medication were compared between placebo and PAR/VAL treatment groups in the days following surgery. Results: Pain scores were reduced in the PAR/VAL group (n=98), relative to placebo (n=97), on Day 2 (−21%, P<0.001) and Day 3 (−23%, P=0.004). Pain interference with function scores were also significantly lower in the PAR/VAL group, compared with placebo, on Day 2 (−29%, P<0.001) and Day 3 (−28%, P=0.013). Consumption of supplemental morphine was significantly lower in the PAR/VAL group relative to placebo at 24 hours (−37%, P=0.010) and trended lower at 48 (−28%) and 72 hours (−26%). Patients in the PAR/VAL group also had a reduced risk of experiencing specific opioid-related symptoms, including “inability to concentrate” (relative risk =0.53) and “nausea” (relative risk =0.60) on Day 2. Both Patient and Physician Global Evaluation of Study Medication scores were better in the PAR/VAL group than in the placebo group. Conclusion: The current study adds support for the use of parecoxib in patients following major gynecologic surgery. Keywords: parecoxib, postoperative pain, gynecologic surgery |
| first_indexed | 2024-12-13T07:43:06Z |
| format | Article |
| id | doaj.art-6d6c75b6df9e409cbff18591c19af516 |
| institution | Directory Open Access Journal |
| issn | 1178-7090 |
| language | English |
| last_indexed | 2024-12-13T07:43:06Z |
| publishDate | 2016-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Pain Research |
| spelling | doaj.art-6d6c75b6df9e409cbff18591c19af5162022-12-21T23:54:55ZengDove Medical PressJournal of Pain Research1178-70902016-11-01Volume 91101110730227Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgeryParsons BZhu QXie LLi CCheung RBruce Parsons,1 Qijiang Zhu,2 Li Xie,3 Chunming Li,1 Raymond Cheung1 1Pfizer Inc, New York, NY, USA; 281st Hospital of Chinese People’s Liberation Army, Nanjing, People’s Republic of China; 3Pfizer Investment Co., Ltd, Beijing, People’s Republic of China Objective: To examine the analgesic and opioid-sparing effects of parecoxib following major gynecologic surgery.Methods: This is a large subset analysis of patients from a multicenter, randomized, double-blind, placebo-controlled study of parecoxib/valdecoxib (PAR/VAL) for postoperative pain. Pain severity, pain interference with function, opioid use, occurrence of opioid-related symptoms, and Patient/Physician Global Evaluation of Study Medication were compared between placebo and PAR/VAL treatment groups in the days following surgery. Results: Pain scores were reduced in the PAR/VAL group (n=98), relative to placebo (n=97), on Day 2 (−21%, P<0.001) and Day 3 (−23%, P=0.004). Pain interference with function scores were also significantly lower in the PAR/VAL group, compared with placebo, on Day 2 (−29%, P<0.001) and Day 3 (−28%, P=0.013). Consumption of supplemental morphine was significantly lower in the PAR/VAL group relative to placebo at 24 hours (−37%, P=0.010) and trended lower at 48 (−28%) and 72 hours (−26%). Patients in the PAR/VAL group also had a reduced risk of experiencing specific opioid-related symptoms, including “inability to concentrate” (relative risk =0.53) and “nausea” (relative risk =0.60) on Day 2. Both Patient and Physician Global Evaluation of Study Medication scores were better in the PAR/VAL group than in the placebo group. Conclusion: The current study adds support for the use of parecoxib in patients following major gynecologic surgery. Keywords: parecoxib, postoperative pain, gynecologic surgeryhttps://www.dovepress.com/effects-of-parecoxib-on-postoperative-pain-and-opioid-related-symptoms-peer-reviewed-article-JPRParecoxibPostoperative painGynecologic surgery |
| spellingShingle | Parsons B Zhu Q Xie L Li C Cheung R Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery Journal of Pain Research Parecoxib Postoperative pain Gynecologic surgery |
| title | Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery |
| title_full | Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery |
| title_fullStr | Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery |
| title_full_unstemmed | Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery |
| title_short | Effects of parecoxib on postoperative pain and opioid-related symptoms following gynecologic surgery |
| title_sort | effects of parecoxib on postoperative pain and opioid related symptoms following gynecologic surgery |
| topic | Parecoxib Postoperative pain Gynecologic surgery |
| url | https://www.dovepress.com/effects-of-parecoxib-on-postoperative-pain-and-opioid-related-symptoms-peer-reviewed-article-JPR |
| work_keys_str_mv | AT parsonsb effectsofparecoxibonpostoperativepainandopioidrelatedsymptomsfollowinggynecologicsurgery AT zhuq effectsofparecoxibonpostoperativepainandopioidrelatedsymptomsfollowinggynecologicsurgery AT xiel effectsofparecoxibonpostoperativepainandopioidrelatedsymptomsfollowinggynecologicsurgery AT lic effectsofparecoxibonpostoperativepainandopioidrelatedsymptomsfollowinggynecologicsurgery AT cheungr effectsofparecoxibonpostoperativepainandopioidrelatedsymptomsfollowinggynecologicsurgery |