Neoadjuvant PD-1 Blockade Combined With Chemotherapy Followed by Concurrent Immunoradiotherapy in Locally Advanced Anal Canal Squamous Cell Carcinoma Patients: Antitumor Efficacy, Safety and Biomarker Analysis

Neoadjuvant PD-1 Blockade Combined With Chemotherapy Followed by Concurrent Immunoradiotherapy in Locally Advanced Anal Canal Squamous Cell Carcinoma Patients: Antitumor Efficacy, Safety and Biomarker Analysis

BackgroundAnal canal squamous cell carcinoma (ACSCC) is an exceedingly rare malignant neoplasm with challenges in sphincter preservation, treatment toxicities and long-term survival. Little is known concerning the activity of PD-1 antibodies in locally advanced ACSCC. This study reports on the effic...

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Bibliographic Details
Main Authors: WeiWei Xiao, Yan Yuan, SuiHai Wang, Zhidong Liao, PeiQiang Cai, BaoQing Chen, Rong Zhang, Fang Wang, ZhiFan Zeng, YuanHong Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
locally advanced
anal canal squamous cell carcinoma
neoadjuvant
PD-1 blockade
PD-L1
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.798451/full

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