Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial
(1) Background: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of all patients with HF. In the absence of pharmacological treatments that have been successful in reducing mortality or morbidity in this pathology, physical exercise is recognized as an impor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/10/3535 |
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| author | Iván Cavero-Redondo Alicia Saz-Lara Irene Martínez-García Bruno Bizzozero-Peroni Valentina Díaz-Goñi Ana Díez-Fernández Nerea Moreno-Herráiz Carlos Pascual-Morena |
| author_facet | Iván Cavero-Redondo Alicia Saz-Lara Irene Martínez-García Bruno Bizzozero-Peroni Valentina Díaz-Goñi Ana Díez-Fernández Nerea Moreno-Herráiz Carlos Pascual-Morena |
| author_sort | Iván Cavero-Redondo |
| collection | DOAJ |
| description | (1) Background: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of all patients with HF. In the absence of pharmacological treatments that have been successful in reducing mortality or morbidity in this pathology, physical exercise is recognized as an important adjunct in the treatment of HF. Therefore, the objective of this study is to compare the efficacy of combined training and high intensity interval training (HIIT) on exercise capacity, diastolic function, endothelial function, and arterial stiffness in participants with HFpEF. (2) Methods: The ExIC-FEp study will be a single-blind, 3-arm, randomized clinical trial (RCT) conducted at the Health and Social Research Center of the University of Castilla-La Mancha. Participants with HFpEF will be randomly assigned (1:1:1) to the combined exercise, HIIT or control group to evaluate the efficacy of physical exercise programs on exercise capacity, diastolic function, endothelial function, and arterial stiffness. All participants will be examined at baseline, at three months and at six months. (3) Results: The findings of this study will be published in a peer-reviewed journal. (4) Conclusions: This RCT will represent a significant advance in the available scientific evidence on the efficacy of physical exercise in the treatment of HFpEF. |
| first_indexed | 2024-03-11T03:37:27Z |
| format | Article |
| id | doaj.art-6d6ed6ae09db4ee9aee79f9587d11bd4 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T03:37:27Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-6d6ed6ae09db4ee9aee79f9587d11bd42023-11-18T01:54:40ZengMDPI AGJournal of Clinical Medicine2077-03832023-05-011210353510.3390/jcm12103535Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled TrialIván Cavero-Redondo0Alicia Saz-Lara1Irene Martínez-García2Bruno Bizzozero-Peroni3Valentina Díaz-Goñi4Ana Díez-Fernández5Nerea Moreno-Herráiz6Carlos Pascual-Morena7Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Talca 3460000, ChileHealth and Social Research Centre, Universidad de Castilla-La Mancha, 16001 Cuenca, SpainHealth and Social Research Centre, Universidad de Castilla-La Mancha, 16001 Cuenca, SpainHealth and Social Research Centre, Universidad de Castilla-La Mancha, 16001 Cuenca, SpainHealth and Social Research Centre, Universidad de Castilla-La Mancha, 16001 Cuenca, SpainHealth and Social Research Centre, Universidad de Castilla-La Mancha, 16001 Cuenca, SpainHealth and Social Research Centre, Universidad de Castilla-La Mancha, 16001 Cuenca, SpainHealth and Social Research Centre, Universidad de Castilla-La Mancha, 16001 Cuenca, Spain(1) Background: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of all patients with HF. In the absence of pharmacological treatments that have been successful in reducing mortality or morbidity in this pathology, physical exercise is recognized as an important adjunct in the treatment of HF. Therefore, the objective of this study is to compare the efficacy of combined training and high intensity interval training (HIIT) on exercise capacity, diastolic function, endothelial function, and arterial stiffness in participants with HFpEF. (2) Methods: The ExIC-FEp study will be a single-blind, 3-arm, randomized clinical trial (RCT) conducted at the Health and Social Research Center of the University of Castilla-La Mancha. Participants with HFpEF will be randomly assigned (1:1:1) to the combined exercise, HIIT or control group to evaluate the efficacy of physical exercise programs on exercise capacity, diastolic function, endothelial function, and arterial stiffness. All participants will be examined at baseline, at three months and at six months. (3) Results: The findings of this study will be published in a peer-reviewed journal. (4) Conclusions: This RCT will represent a significant advance in the available scientific evidence on the efficacy of physical exercise in the treatment of HFpEF.https://www.mdpi.com/2077-0383/12/10/3535physical exerciseheart failureexercise capacitydiastolic functionendothelial functionarterial stiffness |
| spellingShingle | Iván Cavero-Redondo Alicia Saz-Lara Irene Martínez-García Bruno Bizzozero-Peroni Valentina Díaz-Goñi Ana Díez-Fernández Nerea Moreno-Herráiz Carlos Pascual-Morena Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial Journal of Clinical Medicine physical exercise heart failure exercise capacity diastolic function endothelial function arterial stiffness |
| title | Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial |
| title_full | Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial |
| title_fullStr | Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial |
| title_full_unstemmed | Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial |
| title_short | Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial |
| title_sort | comparative effect of two types of physical exercise for the improvement of exercise capacity diastolic function endothelial function and arterial stiffness in participants with heart failure with preserved ejection fraction exic fep study protocol for a randomized controlled trial |
| topic | physical exercise heart failure exercise capacity diastolic function endothelial function arterial stiffness |
| url | https://www.mdpi.com/2077-0383/12/10/3535 |
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