Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory
The cerebellum is involved in higher-order cognitive functions, e.g., learning and memory, and is susceptible to age-related atrophy. Yet, the cerebellum's role in age-related cognitive decline remains largely unknown. We investigated cross-sectional and longitudinal associations between cerebe...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-05-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811923001945 |
| _version_ | 1827968153884295168 |
|---|---|
| author | C'iana P. Cooper Andrea T. Shafer Nicole M. Armstrong Yang An Guray Erus Christos Davatzikos Luigi Ferrucci Peter R. Rapp Susan M. Resnick |
| author_facet | C'iana P. Cooper Andrea T. Shafer Nicole M. Armstrong Yang An Guray Erus Christos Davatzikos Luigi Ferrucci Peter R. Rapp Susan M. Resnick |
| author_sort | C'iana P. Cooper |
| collection | DOAJ |
| description | The cerebellum is involved in higher-order cognitive functions, e.g., learning and memory, and is susceptible to age-related atrophy. Yet, the cerebellum's role in age-related cognitive decline remains largely unknown. We investigated cross-sectional and longitudinal associations between cerebellar volume and verbal learning and memory. Linear mixed effects models and partial correlations were used to examine the relationship between changes in cerebellum volumes (total cerebellum, cerebellum white matter [WM], cerebellum hemisphere gray matter [GM], and cerebellum vermis subregions) and changes in verbal learning and memory performance among 549 Baltimore Longitudinal Study of Aging participants (2,292 visits). All models were adjusted by baseline demographic characteristics (age, sex, race, education), and APOE e4 carrier status. In examining associations between change with change, we tested an additional model that included either hippocampal (HC), cuneus, or postcentral gyrus (PoCG) volumes to assess whether cerebellar volumes were uniquely associated with verbal learning and memory. Cross-sectionally, the association of baseline cerebellum GM and WM with baseline verbal learning and memory was age-dependent, with the oldest individuals showing the strongest association between volume and performance. Baseline volume was not significantly associated with change in learning and memory. However, analysis of associations between change in volumes and changes in verbal learning and memory showed that greater declines in verbal memory were associated with greater volume loss in cerebellum white matter, and preserved GM volume in cerebellum vermis lobules VI-VII. The association between decline in verbal memory and decline in cerebellar WM volume remained after adjustment for HC, cuneus, and PoCG volume. Our findings highlight that associations between cerebellum volume and verbal learning and memory are age-dependent and regionally specific. |
| first_indexed | 2024-04-09T18:16:38Z |
| format | Article |
| id | doaj.art-6d6f49654a754daf93f33c1b37e56604 |
| institution | Directory Open Access Journal |
| issn | 1095-9572 |
| language | English |
| last_indexed | 2024-04-09T18:16:38Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj.art-6d6f49654a754daf93f33c1b37e566042023-04-13T04:26:04ZengElsevierNeuroImage1095-95722023-05-01272120048Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memoryC'iana P. Cooper0Andrea T. Shafer1Nicole M. Armstrong2Yang An3Guray Erus4Christos Davatzikos5Luigi Ferrucci6Peter R. Rapp7Susan M. Resnick8Neurocognitive Aging Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, United StatesBrain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224-6825, United StatesBrain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224-6825, United States; Department of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI, United StatesBrain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224-6825, United StatesSection of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United StatesSection of Biomedical Image Analysis, Department of Radiology, University of Pennsylvania, Philadelphia, PA, United StatesTranslational Gerontology Branch, Longitudinal Studies Section, National Institute on Aging, National Institutes of Health, Baltimore, MD, United StatesNeurocognitive Aging Section, Laboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD, United StatesBrain Aging and Behavior Section, Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, 251 Bayview Boulevard, Suite 100, Baltimore, MD 21224-6825, United States; Corresponding author.The cerebellum is involved in higher-order cognitive functions, e.g., learning and memory, and is susceptible to age-related atrophy. Yet, the cerebellum's role in age-related cognitive decline remains largely unknown. We investigated cross-sectional and longitudinal associations between cerebellar volume and verbal learning and memory. Linear mixed effects models and partial correlations were used to examine the relationship between changes in cerebellum volumes (total cerebellum, cerebellum white matter [WM], cerebellum hemisphere gray matter [GM], and cerebellum vermis subregions) and changes in verbal learning and memory performance among 549 Baltimore Longitudinal Study of Aging participants (2,292 visits). All models were adjusted by baseline demographic characteristics (age, sex, race, education), and APOE e4 carrier status. In examining associations between change with change, we tested an additional model that included either hippocampal (HC), cuneus, or postcentral gyrus (PoCG) volumes to assess whether cerebellar volumes were uniquely associated with verbal learning and memory. Cross-sectionally, the association of baseline cerebellum GM and WM with baseline verbal learning and memory was age-dependent, with the oldest individuals showing the strongest association between volume and performance. Baseline volume was not significantly associated with change in learning and memory. However, analysis of associations between change in volumes and changes in verbal learning and memory showed that greater declines in verbal memory were associated with greater volume loss in cerebellum white matter, and preserved GM volume in cerebellum vermis lobules VI-VII. The association between decline in verbal memory and decline in cerebellar WM volume remained after adjustment for HC, cuneus, and PoCG volume. Our findings highlight that associations between cerebellum volume and verbal learning and memory are age-dependent and regionally specific.http://www.sciencedirect.com/science/article/pii/S1053811923001945CerebellumCVLTVerbal memoryBLSAMRILongitudinal |
| spellingShingle | C'iana P. Cooper Andrea T. Shafer Nicole M. Armstrong Yang An Guray Erus Christos Davatzikos Luigi Ferrucci Peter R. Rapp Susan M. Resnick Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory NeuroImage Cerebellum CVLT Verbal memory BLSA MRI Longitudinal |
| title | Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory |
| title_full | Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory |
| title_fullStr | Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory |
| title_full_unstemmed | Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory |
| title_short | Associations of baseline and longitudinal change in cerebellum volume with age-related changes in verbal learning and memory |
| title_sort | associations of baseline and longitudinal change in cerebellum volume with age related changes in verbal learning and memory |
| topic | Cerebellum CVLT Verbal memory BLSA MRI Longitudinal |
| url | http://www.sciencedirect.com/science/article/pii/S1053811923001945 |
| work_keys_str_mv | AT cianapcooper associationsofbaselineandlongitudinalchangeincerebellumvolumewithagerelatedchangesinverballearningandmemory AT andreatshafer associationsofbaselineandlongitudinalchangeincerebellumvolumewithagerelatedchangesinverballearningandmemory AT nicolemarmstrong associationsofbaselineandlongitudinalchangeincerebellumvolumewithagerelatedchangesinverballearningandmemory AT yangan associationsofbaselineandlongitudinalchangeincerebellumvolumewithagerelatedchangesinverballearningandmemory AT gurayerus associationsofbaselineandlongitudinalchangeincerebellumvolumewithagerelatedchangesinverballearningandmemory AT christosdavatzikos associationsofbaselineandlongitudinalchangeincerebellumvolumewithagerelatedchangesinverballearningandmemory AT luigiferrucci associationsofbaselineandlongitudinalchangeincerebellumvolumewithagerelatedchangesinverballearningandmemory AT peterrrapp associationsofbaselineandlongitudinalchangeincerebellumvolumewithagerelatedchangesinverballearningandmemory AT susanmresnick associationsofbaselineandlongitudinalchangeincerebellumvolumewithagerelatedchangesinverballearningandmemory |