BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity

BDNF trafficking and signaling impairment during early neurodegeneration is prevented by moderate physical activity

Physical exercise can attenuate the effects of aging on the central nervous system by increasing the expression of neurotrophins such as brain-derived neurotrophic factor (BDNF), which promotes dendritic branching and enhances synaptic machinery, through interaction with its receptor TrkB. TrkB rece...

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Bibliographic Details
Main Authors: Michael F. Almeida, Rodrigo S. Chaves, Carolliny M. Silva, Juliana C.S. Chaves, Karla P. Melo, Merari F.R. Ferrari
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:IBRO Reports
Subjects:
TrkB receptor
Treadmill running
Hyperphosphorylated Tau
Early neurodegeneration
Aging
Hippocampus
Online Access:http://www.sciencedirect.com/science/article/pii/S2451830116300036

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