Trehalose against UVB-induced skin photoaging by suppressing MMP expression and enhancing procollagen I synthesis in HaCaT cells
Ultraviolet radiation B cause photoaging of the skin by enhancing the high expression of matrix metalloproteinases (MMPs) to degrade collagen and inhibit the synthesis of procollagen. Trehalose (TRE), a widely occurring natural disaccharide, has been shown to play a cytoprotective role in many patho...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-11-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464620304229 |
| _version_ | 1818950184367816704 |
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| author | Zhenbang Xiao Shengtao Yang Jiali Chen Chengyong Li Chunxia Zhou Pengzhi Hong Shengli Sun Zhong-Ji Qian |
| author_facet | Zhenbang Xiao Shengtao Yang Jiali Chen Chengyong Li Chunxia Zhou Pengzhi Hong Shengli Sun Zhong-Ji Qian |
| author_sort | Zhenbang Xiao |
| collection | DOAJ |
| description | Ultraviolet radiation B cause photoaging of the skin by enhancing the high expression of matrix metalloproteinases (MMPs) to degrade collagen and inhibit the synthesis of procollagen. Trehalose (TRE), a widely occurring natural disaccharide, has been shown to play a cytoprotective role in many pathological processes. However, few studies have evaluated whether it has anti-photoaging potential. In this study, we investigated the anti-photoaging and mechanism of action of TRE using Human immortalized keratinocytes (HaCaT) cells. The results indicated that TRE pretreatment effectively scavenges reactive oxygen species (ROS) accumulation induced by UVB and increases the content of certain endogenous antioxidant factors in HaCaT cells. TRE suppressed UVB-induced MMP expression by blocking mitogen-activated protein kinases (MAPKs), activator protein 1 (AP-1) and NF-κB signaling. TRE treatment increased procollagen I synthesis via activating transforming growth factor-β (TGF-β)/Smad pathway and demonstrated that TRE may be a potential natural disaccharide for photoaging therapy in the future. |
| first_indexed | 2024-12-20T09:14:33Z |
| format | Article |
| id | doaj.art-6d6fca4a70324840bc31aa86fe022894 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-20T09:14:33Z |
| publishDate | 2020-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-6d6fca4a70324840bc31aa86fe0228942022-12-21T19:45:28ZengElsevierJournal of Functional Foods1756-46462020-11-0174104198Trehalose against UVB-induced skin photoaging by suppressing MMP expression and enhancing procollagen I synthesis in HaCaT cellsZhenbang Xiao0Shengtao Yang1Jiali Chen2Chengyong Li3Chunxia Zhou4Pengzhi Hong5Shengli Sun6Zhong-Ji Qian7School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, ChinaSouthern Marine Science and Engineering Guangdong Laboratory, Zhanjiang 524088, China; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, ChinaSouthern Marine Science and Engineering Guangdong Laboratory, Zhanjiang 524088, China; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, ChinaSchool of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China; Southern Marine Science and Engineering Guangdong Laboratory, Zhanjiang 524088, China; Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, ChinaSouthern Marine Science and Engineering Guangdong Laboratory, Zhanjiang 524088, China; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, ChinaSouthern Marine Science and Engineering Guangdong Laboratory, Zhanjiang 524088, China; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, ChinaSchool of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, ChinaSchool of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China; Southern Marine Science and Engineering Guangdong Laboratory, Zhanjiang 524088, China; Shenzhen Institute of Guangdong Ocean University, Shenzhen 518108, China; Corresponding author at: School of Chemistry and Environment, Guangdong Ocean University, Zhanjiang 524088, China.Ultraviolet radiation B cause photoaging of the skin by enhancing the high expression of matrix metalloproteinases (MMPs) to degrade collagen and inhibit the synthesis of procollagen. Trehalose (TRE), a widely occurring natural disaccharide, has been shown to play a cytoprotective role in many pathological processes. However, few studies have evaluated whether it has anti-photoaging potential. In this study, we investigated the anti-photoaging and mechanism of action of TRE using Human immortalized keratinocytes (HaCaT) cells. The results indicated that TRE pretreatment effectively scavenges reactive oxygen species (ROS) accumulation induced by UVB and increases the content of certain endogenous antioxidant factors in HaCaT cells. TRE suppressed UVB-induced MMP expression by blocking mitogen-activated protein kinases (MAPKs), activator protein 1 (AP-1) and NF-κB signaling. TRE treatment increased procollagen I synthesis via activating transforming growth factor-β (TGF-β)/Smad pathway and demonstrated that TRE may be a potential natural disaccharide for photoaging therapy in the future.http://www.sciencedirect.com/science/article/pii/S1756464620304229TrehalosePhotoagingOxidative stressHaCaT cellsUVB |
| spellingShingle | Zhenbang Xiao Shengtao Yang Jiali Chen Chengyong Li Chunxia Zhou Pengzhi Hong Shengli Sun Zhong-Ji Qian Trehalose against UVB-induced skin photoaging by suppressing MMP expression and enhancing procollagen I synthesis in HaCaT cells Journal of Functional Foods Trehalose Photoaging Oxidative stress HaCaT cells UVB |
| title | Trehalose against UVB-induced skin photoaging by suppressing MMP expression and enhancing procollagen I synthesis in HaCaT cells |
| title_full | Trehalose against UVB-induced skin photoaging by suppressing MMP expression and enhancing procollagen I synthesis in HaCaT cells |
| title_fullStr | Trehalose against UVB-induced skin photoaging by suppressing MMP expression and enhancing procollagen I synthesis in HaCaT cells |
| title_full_unstemmed | Trehalose against UVB-induced skin photoaging by suppressing MMP expression and enhancing procollagen I synthesis in HaCaT cells |
| title_short | Trehalose against UVB-induced skin photoaging by suppressing MMP expression and enhancing procollagen I synthesis in HaCaT cells |
| title_sort | trehalose against uvb induced skin photoaging by suppressing mmp expression and enhancing procollagen i synthesis in hacat cells |
| topic | Trehalose Photoaging Oxidative stress HaCaT cells UVB |
| url | http://www.sciencedirect.com/science/article/pii/S1756464620304229 |
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