Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity
Abstract Background Because of its poor intrinsic repair capacity, articular cartilage seldom heals when damaged. Main body Regenerative treatment is expected for the treatment of articular cartilage damage, and allogeneic chondrocytes or cartilage have an advantage over autologous chondrocytes, whi...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Inflammation and Regeneration |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41232-023-00307-0 |
| _version_ | 1797577443080404992 |
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| author | Kengo Abe Noriyuki Tsumaki |
| author_facet | Kengo Abe Noriyuki Tsumaki |
| author_sort | Kengo Abe |
| collection | DOAJ |
| description | Abstract Background Because of its poor intrinsic repair capacity, articular cartilage seldom heals when damaged. Main body Regenerative treatment is expected for the treatment of articular cartilage damage, and allogeneic chondrocytes or cartilage have an advantage over autologous chondrocytes, which are limited in number. However, the presence or absence of an immune response has not been analyzed and remains controversial. Allogeneic-induced pluripotent stem cell (iPSC)–derived cartilage, a new resource for cartilage regeneration, reportedly survived and integrated with native cartilage after transplantation into chondral defects in knee joints without immune rejection in a recent primate model. Here, we review and discuss the immunogenicity of chondrocytes and the efficacy of allogeneic cartilage transplantation, including iPSC-derived cartilage. Short conclusion Allogeneic iPSC-derived cartilage transplantation, a new therapeutic option, could be a good indication for chondral defects, and the development of translational medical technology for articular cartilage damage is expected. |
| first_indexed | 2024-03-10T22:09:23Z |
| format | Article |
| id | doaj.art-6d73232973b24d25be8aa006163258cb |
| institution | Directory Open Access Journal |
| issn | 1880-8190 |
| language | English |
| last_indexed | 2024-03-10T22:09:23Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Inflammation and Regeneration |
| spelling | doaj.art-6d73232973b24d25be8aa006163258cb2023-11-19T12:41:10ZengBMCInflammation and Regeneration1880-81902023-11-0143111010.1186/s41232-023-00307-0Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicityKengo Abe0Noriyuki Tsumaki1Department of Tissue Biochemistry, Graduate School of Medicine, Osaka UniversityDepartment of Tissue Biochemistry, Graduate School of Medicine, Osaka UniversityAbstract Background Because of its poor intrinsic repair capacity, articular cartilage seldom heals when damaged. Main body Regenerative treatment is expected for the treatment of articular cartilage damage, and allogeneic chondrocytes or cartilage have an advantage over autologous chondrocytes, which are limited in number. However, the presence or absence of an immune response has not been analyzed and remains controversial. Allogeneic-induced pluripotent stem cell (iPSC)–derived cartilage, a new resource for cartilage regeneration, reportedly survived and integrated with native cartilage after transplantation into chondral defects in knee joints without immune rejection in a recent primate model. Here, we review and discuss the immunogenicity of chondrocytes and the efficacy of allogeneic cartilage transplantation, including iPSC-derived cartilage. Short conclusion Allogeneic iPSC-derived cartilage transplantation, a new therapeutic option, could be a good indication for chondral defects, and the development of translational medical technology for articular cartilage damage is expected.https://doi.org/10.1186/s41232-023-00307-0Articular cartilageChondrocytesInduced pluripotent stem cellsAllogeneic transplantationImmune response |
| spellingShingle | Kengo Abe Noriyuki Tsumaki Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity Inflammation and Regeneration Articular cartilage Chondrocytes Induced pluripotent stem cells Allogeneic transplantation Immune response |
| title | Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity |
| title_full | Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity |
| title_fullStr | Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity |
| title_full_unstemmed | Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity |
| title_short | Regeneration of joint surface defects by transplantation of allogeneic cartilage: application of iPS cell-derived cartilage and immunogenicity |
| title_sort | regeneration of joint surface defects by transplantation of allogeneic cartilage application of ips cell derived cartilage and immunogenicity |
| topic | Articular cartilage Chondrocytes Induced pluripotent stem cells Allogeneic transplantation Immune response |
| url | https://doi.org/10.1186/s41232-023-00307-0 |
| work_keys_str_mv | AT kengoabe regenerationofjointsurfacedefectsbytransplantationofallogeneiccartilageapplicationofipscellderivedcartilageandimmunogenicity AT noriyukitsumaki regenerationofjointsurfacedefectsbytransplantationofallogeneiccartilageapplicationofipscellderivedcartilageandimmunogenicity |